Polydatin Incorporated in Polycaprolactone Nanofibers Improves Osteogenic Differentiation

Polycaprolactone nanofibers are used as scaffolds in the field of tissue engineering for tissue regeneration or drug delivery. Polycaprolactone (PCL) is a biodegradable hydrophobic polyester used to obtain implantable nanostructures, which are clinically applicable due to their biological safety. Po...

Full description

Bibliographic Details
Published in:	Pharmaceuticals
Main Authors:	Stefania Lama, Amalia Luce, Giuseppe Bitti, Pilar Chacon-Millan, Annalisa Itro, Pasquale Ferranti, Giovanni D’Auria, Marcella Cammarota, Giovanni Francesco Nicoletti, Giuseppe Andrea Ferraro, Chiara Schiraldi, Michele Caraglia, Evzen Amler, Paola Stiuso
Format:	Article
Language:	English
Published:	MDPI AG 2022-06-01
Subjects:	osteosarcoma polydatin osteogenic differentiation mesenchymal stem cells polycaprolactone nanofibers
Online Access:	https://www.mdpi.com/1424-8247/15/6/727

Similar Items

Polydatin improves osteogenic differentiation of human bone mesenchymal stem cells by stimulating TAZ expression via BMP2-Wnt/β-catenin signaling pathway
by: Ying-Shan Shen, et al.
Published: (2020-05-01)

Fabrication and characterization of polycaprolactone and tricalcium phosphate composites for tissue engineering applications
by: Shu-Hsien Huang, et al.
Published: (2017-03-01)

Polydatin: A natural compound with multifaceted anticancer properties
by: Khalid Imtiyaz, et al.
Published: (2025-09-01)

Targeting autophagy: polydatin’s role in inducing cell death in AML
by: Ping Fu, et al.
Published: (2024-11-01)

Co-micronized palmitoylethanolamide/polydatin treatment causes endometriotic lesion regression in a rodent model of surgically-induced endometriosis
by: Rosanna Di Paola, et al.
Published: (2016-10-01)

Polydatin-Induced Shift of Redox Balance and Its Anti-Cancer Impact on Human Osteosarcoma Cells
by: Alessio Cimmino, et al.
Published: (2024-12-01)

Polydatin exerts therapeutic effects on myelodysplastic syndrome by inhibiting the protein expression of oncogenes via hypermethylation in vitro
by: Qingbing Zhou, et al.
Published: (2025-05-01)

Polydatin alleviates mycoplasma pneumoniae-induced injury via inhibition of Caspase-1/GSDMD-dependent pyroptosis
by: Yiliu Chen, et al.
Published: (2023-09-01)

A Study of the Effects of Oleuropein and Polydatin Association on Muscle and Bone Metabolism
by: Maria Beatrice Morelli, et al.
Published: (2025-04-01)

Polydatin inhibits the stemness and angiogenesis of gastric cancer cells by targeting down-regulation of HDAC7
by: Jialin Zhou, et al.
Published: (2025-05-01)

Polydatin Counteracts 5-Fluorouracil Resistance by Enhancing Apoptosis via Calcium Influx in Colon Cancer
by: Hyocheol Bae, et al.
Published: (2021-09-01)

Role of Parkin-mediated mitophagy in the protective effect of polydatin in sepsis-induced acute kidney injury
by: Youguang Gao, et al.
Published: (2020-03-01)

3D-printed Mg-1Ca/polycaprolactone composite scaffolds with promoted bone regeneration
by: Xiao Zhao, et al.
Published: (2024-03-01)

Polydatin retards the progression of osteoarthritis by maintaining bone metabolicbalance and inhibiting macrophage polarization
by: Qi Sun, et al.
Published: (2025-01-01)

Application of β-Glucosidase in a Biphasic System for the Efficient Conversion of Polydatin to Resveratrol
by: Jie Zhou, et al.
Published: (2022-02-01)

Effects of Polydatin on Pentylenetetrazol-Induced Seizures in Zebrafish Larvae
by: Fernanda Barros de Miranda, et al.
Published: (2025-05-01)

Antioxidant Activity and Mechanism of Resveratrol and Polydatin Isolated from Mulberry (<i>Morus alba</i> L.)
by: Ziwei Li, et al.
Published: (2021-12-01)

Polydatin ameliorates hyperhidrosis by targeting Aqp5 in a mouse model
by: Jian-Feng Chen, et al.
Published: (2025-08-01)

Quantitative analysis of Polydatin in a Turkish oak: Quercus coccifera L. with HPLC-DAD
by: Merve Yüzbaşıoğlu Baran, et al.
Published: (2019-10-01)

Polydatin inhibits cell proliferation, invasion and migration, and induces cell apoptosis in hepatocellular carcinoma
by: Yang Jiao, et al.
Published: (2018-03-01)

Polycaprolactone nanofiber scaffold enhances the osteogenic differentiation potency of various human tissue-derived mesenchymal stem cells
by: Ruyue Xue, et al.
Published: (2017-06-01)

Polydatin Alleviates Diabetes-Induced Hyposalivation through Anti-Glycation Activity in db/db Mouse
by: Hyung Rae Kim, et al.
Published: (2021-12-01)

Polydatin Attenuates Neuronal Loss via Reducing Neuroinflammation and Oxidative Stress in Rat MCAO Models
by: Fawad Ali Shah, et al.
Published: (2019-06-01)

Polydatin combined with hawthorn flavonoids alleviate high fat diet induced atherosclerosis by remodeling the gut microbiota and glycolipid metabolism
by: Dan Li, et al.
Published: (2025-03-01)

Potential of Polydatin Against Ischemia-Reperfusion Injury: New Insights from Pharmacological-Pathological Mechanism Associations
by: Sun Z, et al.
Published: (2025-03-01)

Polydatin: Pharmacological Mechanisms, Therapeutic Targets, Biological Activities, and Health Benefits
by: Ahmad Karami, et al.
Published: (2022-10-01)

The Neuroprotective Role of Polydatin: Neuropharmacological Mechanisms, Molecular Targets, Therapeutic Potentials, and Clinical Perspective
by: Sajad Fakhri, et al.
Published: (2021-10-01)

Multitargeted biological actions of polydatin in preventing pseudogout acute attack
by: Chiara Baggio, et al.
Published: (2025-02-01)

Polydatin has anti‐inflammatory and antioxidant effects in LPS‐induced macrophages and improves DSS‐induced mice colitis
by: Guangxin Chen, et al.
Published: (2021-09-01)

Comparison of interventional effects of polydatin on experimental silicosis rats by different administration methods
by: WU Bingbing
Published: (2024-06-01)

PEA/Polydatin: Anti-Inflammatory and Antioxidant Approach to Counteract DNBS-Induced Colitis
by: Alessio Filippo Peritore, et al.
Published: (2021-03-01)

Effect of polydatin on the viability and odontogenic differentiation of human dental pulp stem cells: An in-vitro study
by: Rawan Al-Ateeq, et al.
Published: (2024-10-01)

Polydatin and Resveratrol Inhibit the Inflammatory Process Induced by Urate and Pyrophosphate Crystals in THP-1 Cells
by: Francesca Oliviero, et al.
Published: (2019-11-01)

Odontogenic/osteogenic differentiation of dental pulp stem cells on a Biodentine-coated polymer nanofibers
by: Zahra Sarvarian, et al.
Published: (2025-07-01)

Polydatin Encapsulated Poly [Lactic-co-glycolic acid] Nanoformulation Counteract the 7,12-Dimethylbenz[a] Anthracene Mediated Experimental Carcinogenesis through the Inhibition of Cell Proliferation
by: Sankaran Vijayalakshmi, et al.
Published: (2019-09-01)

Polydatin prevents cholesterol gallstone formation by regulating cholesterol metabolism via PPAR-γ signaling
by: Li Jun, et al.
Published: (2025-08-01)

Polydatin Modulates Inflammatory Cytokine Expression in Lipoteichoic Acid-Stimulated Human Dental-Pulp Stem Cells
by: Rawan Al-Ateeq, et al.
Published: (2025-09-01)

The Influence of Vitamin C–incorporated Polycaprolactone on Osteogenesis in Osteoblast-Osteoclast Co-culture In Vitro
by: Elaf Akram Abdulhameed, et al.
Published: (2025-10-01)

Polydatin attenuates Alzheimer’s disease induced by aluminum chloride in rats: evidence for its antioxidant and anti-inflammatory effects
by: Seyede Nazanin Zarneshan, et al.
Published: (2025-04-01)

Polydatin, a Glycoside of Resveratrol, Induces Apoptosis and Inhibits Metastasis Oral Squamous Cell Carcinoma Cells In Vitro
by: Tae-Hyun Bang, et al.
Published: (2021-09-01)