Corneal Descemetocele Management with Multi-Layer Amniotic Membrane Transplantation in an Ocular Graft-versus-Host Disease Case

• 出版年: Medicina
• 主要な著者: Yunjiao He, Hiufong Wong, Jianjun Gu, Lixia Lin
• フォーマット: 論文
• 言語: 英語
• 出版事項: MDPI AG 2023-09-01
• 主題: ocular graft-versus-host disease (oGVHD); corneal descemetocele; sterile corneal melting; amniotic membrane transplantation; case report
• オンライン･アクセス: https://www.mdpi.com/1648-9144/59/10/1733

<i>Background</i>: Chronic ocular graft-versus-host disease (oGVHD) is a common ocular complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT), characterized by progressive inflammation of the ocular surface and refractory dry eye. In severe cases, sterile corneal perforation can occur, which poses a significant challenge, due to the low survival rate of grafts after corneal transplantation. <i>Case Presentation</i>: A 47-year-old female presented to our hospital with persistent dryness, foreign body sensation, and blurred vision in her left eye. Diagnosis of graft-versus-host disease with corneal descemetocele in the left eye was made after detailed history review and thorough examination. Multi-layer amniotic membrane transplantation was performed in the affected eye, resulting in amelioration of the patient’s symptoms. This amelioration of symptoms provided the patient with a level of comfort that permitted additional time while awaiting corneal transplantation. <i>Conclusions</i>: We report a successful case of multi-layer amniotic membrane transplantation for the management of corneal descemetocele following allo-HSCT.