Losartan Alleviates the Side Effects and Maintains the Anticancer Activity of Axitinib

Axitinib is one of the most potent inhibitors of the vascular endothelial growth factor (VEGF) receptor and shows strong antitumor activity toward various malignant tumors. However, its severe side effects affect the quality of life and prognosis of patients. Losartan, which functions as a typical a...

Full description

Bibliographic Details
Published in:	Molecules
Main Authors:	Ying Fu, Rengui Saxu, Kadir Ahmad Ridwan, Jiaping Yao, Xiaoxuan Chen, Xueping Xu, Weida Zheng, Peng Yu, Yuou Teng
Format:	Article
Language:	English
Published:	MDPI AG 2022-04-01
Subjects:	axitinib VEGF receptor inhibitor losartan angiotensin receptor blockers side effect antitumor
Online Access:	https://www.mdpi.com/1420-3049/27/9/2764

Similar Items

Fifty‐Four Tablets Too Many: A Case Report of Amlodipine and Losartan Overdose
by: Nishan Uprety, et al.
Published: (2025-04-01)

Cutaneous ulcers in association with sprue‐like enteropathy secondary to Losartan
by: Francis Essien, et al.
Published: (2021-08-01)

A randomised clinical trial study assessing the efficacy of 5% losartan potassium loaded in ethosomal gel to treat human keloids: a trial protocol
by: Yuni Eka Anggraini, et al.
Published: (2024-01-01)

Efficacy and safety of losartan in childhood immunoglobulin A nephropathy: a prospective multicenter study
by: Hyesun Hyun, et al.
Published: (2023-12-01)

The role of angiotensin receptor blocker (losartan) on decreasing fibrotic process of corpora cavernosa in priapism model of wistar rats [version 3; peer review: 1 approved, 2 approved with reservations]
by: Rangga Adhazi Ksatriapraja, et al.
Published: (2024-02-01)

The role of angiotensin receptor blocker (losartan) on decreasing fibrotic process of corpora cavernosa in priapism model of wistar rats [version 2; peer review: 1 approved, 2 approved with reservations]
by: Rangga Adhazi Ksatriapraja, et al.
Published: (2023-05-01)

Skin Reactions with Losartan and Enalapril in Cardiac Patients
by: Fariba Iraji, et al.
Published: (2012-03-01)

EFFECT OF ANGIOTENSIN-II RECEPTOR ANTAGONIST LOSARTAN AND ITS COMBINATION WITH DIURETICS ON MYOCARDIAL MORPHO-FUNCTIONAL CONDITIONS IN HYPERTENSIVE PATIENTS WITH LEFT VENTRICULAR HYPERTROPHY
by: S. N. Tolpygina, et al.
Published: (2016-01-01)

Losartan inhibits hyposmotic-induced increase of IKs current and shortening of action potential duration in guinea pig atrial myocytes
by: Jie Gao, et al.
Published: (2019-12-01)

Reduction in left ventricular hypertrophy in hypertensive patients treated with enalapril, losartan or the combination of enalapril and losartan
by: Antônio Carlos Avanza Jr, et al.
Published: (2000-02-01)

Angiotensin II type 1 receptor blockers prevent aortic arterial stiffness in elderly patients with hypertension
by: Mo-Li Zhu, et al.
Published: (2019-10-01)

Modulation of ACE2/Ang1-7/Mas and ACE/AngII/AT1 axes affects anticancer properties of sertraline in MCF-7 breast cancer cells
by: Reihaneh Fatehi, et al.
Published: (2024-07-01)

Case report of a renal cell carcinoma patient with acute pancreatitis under both sunitinib and axitinib treatment
by: Utku Oflazoglu, et al.
Published: (2016-08-01)

Losartan improved hippocampal long‐term potentiation impairment induced by repeated LPS injection in rats
by: Mahmoud Hosseini, et al.
Published: (2021-05-01)

Determining the Effects of Morphine, Heroin, and Losartan and the Interaction of each on Losartan in Water Homeostasis Mechanisms by the Kidney in Adult Male Rabbits
by: F Foroohi, et al.
Published: (2015-04-01)

Acute Angiotensin II Receptor Blockade Facilitates Parahippocampal Processing During Memory Encoding in High-Trait-Anxious Individuals
by: Lorika Shkreli, et al.
Published: (2024-03-01)

Angiotensin receptor blockers might be protective against hepatic steatosis after liver transplantation
by: Ahad Eshraghian, et al.
Published: (2023-05-01)

Solvates and Polymorphs of Axitinib: Characterization and Phase Transformation
by: Yinhu Pan, et al.
Published: (2024-10-01)

Design, Synthesis, and Biological Evaluation of Axitinib Derivatives
by: Na Wei, et al.
Published: (2018-03-01)

Anti-stress activity in a polytropic spectrum of pharmacological action of losartan
by: A. O. Syrovay
Published: (2013-02-01)

Disease modifying effects of simvastatin &/or telmisartan on pulmonary function in patients with mild to moderate chronic obstructive pulmonary disease(COPD)
by: Ali M. Hadi, et al.
Published: (2012-01-01)

The Angiotensin II Type 1 Receptor Antagonist Losartan Affects NHE1-Dependent Melanoma Cell Behavior
by: Daniel Navin Olschewski, et al.
Published: (2018-03-01)

Determination of Losartan and Losartan Carboxylic acid in Human Plasma by New HPLC Method with Fluorescence Detection for Pharmacokinetics Studies
by: Ahmed Abbas Hussein
Published: (2014-12-01)

UPLC-MS/MS analysis of axitinib and pharmacokinetic application in beagle dogs
by: Hengyu Bi, et al.
Published: (2024-10-01)

Axitinib in metastatic renal cell carcinoma: single center experience
by: Agnieszka Buraczewska, et al.
Published: (2017-01-01)

Effect of selective angiotensin antagonists on the antidiuresis produced by angiotensin-(1-7) in water-loaded rats
by: Baracho N.C.V., et al.
Published: (1998-01-01)

The complete reversal effect following angiotensin-converting enzyme inhibitors or angiotensin receptor blockers and beta-blockers after the primary diagnosis of dilated cardiomyopathy
by: Tao Liu, et al.
Published: (2023-01-01)

The Evolving Role of Calcium Channel Blockers in Hypertension Management: Pharmacological and Clinical Considerations
by: Kamryn E. Jones, et al.
Published: (2024-06-01)

Vasorelaxant Effect of a Newly Synthesized Dihydropyridine Ethyl Ester (DHPEE) on Rat Thoracic Aorta: Dual Mechanism of Action
by: Hossein Babaei, et al.
Published: (2011-06-01)

Molecular targeting therapy with angiotensin II receptor blocker for prostatic cancer
by: Hiroji Uemura, et al.
Published: (2011-12-01)

Olmesartan in Management of Proteinuria
by: Satyanarayan Routray, et al.
Published: (2018-02-01)

Axitinib in sequential therapy in metastatic renal cell carcinoma
by: Agata Kuchar, et al.
Published: (2015-05-01)

Improvement of Bone Health and Initiation of Puberty Development in Camurati-Engelmann Disease With Glucocorticoid and Losartan Treatment: A Case Report and Review of Literature
by: Lijia Cui, et al.
Published: (2022-06-01)

Renin angiotensin system blockage by losartan neutralize hypercholesterolemia-induced inflammatory and oxidative injuries
by: Abdulaziz M.S. AlSaad, et al.
Published: (2020-01-01)

Effect of Angiotensin Receptor Inhibitors on Endothelial Dysfunction
by: Alaleh Gheisari, et al.
Published: (2011-10-01)

Sacubitril/valsartan: evaluation of safety and efficacy as an antihypertensive treatment
by: Sarah L Anderson, et al.
Published: (2018-08-01)

Inhibition of Axitinib on Buspirone Metabolism in vitro and in vivo
by: Zhang BW, et al.
Published: (2022-06-01)

Systemic hypertension with VEGFR inhibitor (axitinib) therapy in cancer patients: A meta-analysis and systematic review of randomized controlled trials
by: Aravind Dilli Babu, et al.
Published: (2024-06-01)

Response to Combination of Pembrolizumab and Axitinib in Hereditary Leyomiomatosis and Renal Cell Cancer (HLRCC)
by: Ibon Gurruchaga Sotés, et al.
Published: (2021-06-01)

Rationale and Design of a Randomized, Open‐Label, Parallel‐Group Study of Esaxerenone Versus Angiotensin Receptor Blockers in Older Patients With Uncontrolled Hypertension on Calcium Channel Blocker Monotherapy (ESCORT‐HT)
by: Kazuomi Kario, et al.
Published: (2025-01-01)