Treatment of hypothyroidism with levothyroxine plus slow-release liothyronine: a study protocol for a randomized controlled double-blinded clinical trial

Abstract Background There are emerging controversies regarding the priority of T4 + T3 combination therapy over standard care with levothyroxine (LT4) monotherapy in the management of hypothyroid subjects. Combination therapy with a slow-release form of liothyronine (SRT3) and levothyroxine may rest...

Full description

Bibliographic Details
Published in:	Trials
Main Authors:	F. Azizi, A. Amouzegar, H. Abdi, M. Tohidi, S. Masoumi, D. Khalili, Y. Mehrabi, A. Zadehvakili, M. Hedayati, A. A. Momenan, L. Mehran
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Subjects:	Hypothyroidism Levothyroxine Slow-release liothyronine Combination therapy Clinical trial Patient-reported outcomes
Online Access:	https://doi.org/10.1186/s13063-025-08940-5

Similar Items

Pharmacodynamic and pharmacokinetic properties of the combined preparation of levothyroxine plus sustained- release liothyronine; a randomized controlled clinical trial
by: Ladan Mehran, et al.
Published: (2023-08-01)

A feasibility double-blind trial of levothyroxine vs. levothyroxine-liothyronine in postsurgical hypothyroidism
by: Giao Q. Phan, et al.
Published: (2025-03-01)

Treatment of hypothyroidism with the combination of levothyroxine and slow-release triiodothyronine: a randomized clinical trial
by: F. Azizi, et al.
Published: (2025-06-01)

Differentiation Between Clinical and Subclinical Hypothyroidism in Pathophysiology, Symptoms, Diagnosis and Treatment – A Narrative Review
by: Mustafa Mohammed Albassam, et al.
Published: (2024-09-01)

Editorial: (Re)defining hypothyroidism: the key to patient-centered treatment
by: Antonio C. Bianco, et al.
Published: (2024-02-01)

Quality by design driven RP-HPLC method optimization for analysis of levothyroxine and liothyronine in bulk and tablet dosage form
by: Ramdas Darade, et al.
Published: (2025-04-01)

Evaluating the effectiveness of combined T4 and T3 therapy or desiccated thyroid versus T4 monotherapy in hypothyroidism: a systematic review and meta-analysis
by: Mahmoud Nassar, et al.
Published: (2024-06-01)

Thyroid hormone use in clinical practice by Israeli endocrinologists: a THESIS* questionnaire survey
by: Liat Sasson, et al.
Published: (2025-03-01)

Triiodothyronine levels in athyreotic pediatric patients during levothyroxine therapy
by: Julia Baran, et al.
Published: (2024-08-01)

Combination therapy of liothyronine and levothyroxine for hypothyroidism-induced dilated cardiomyopathy
by: Youngha Choi, et al.
Published: (2022-06-01)

A questionnaire survey of thyroid specialists in Japan on the use of thyroid hormones in hypothyroid and euthyroid patients
by: Yuji Nagayama, et al.
Published: (2025-08-01)

Use of thyroid hormones in hypothyroid and euthyroid patients: a 2022 THESIS questionnaire survey of members of the Latin American Thyroid Society (LATS)
by: Jessica F. Cassemiro, et al.
Published: (2023-09-01)

Early postoperative levothyroxine initiation after total thyroidectomy for Graves’ disease
by: Yuji Nagayama, et al.
Published: (2025-07-01)

Use of thyroid hormones in hypothyroid and euthyroid patients: a THESIS* questionnaire survey of Polish physicians. *THESIS: Treatment of hypothyroidism in Europe by specialists: an international survey
by: Tomasz Bednarczuk, et al.
Published: (2021-08-01)

Managing symptoms in hypothyroid patients on adequate levothyroxine: a narrative review
by: Salman Razvi, et al.
Published: (2020-12-01)

Levothyroxine supplementation among individuals with Subclinical Hypothyroidism and Depression | a review
by: M. Ribeiro, et al.
Published: (2022-06-01)

Role of T3 in Management of Hypothyroidism
by: Sanjay Kalra, et al.
Published: (2025-07-01)

ETA guidelines for the use of levothyroxine sodium preparations in monotherapy to optimize the treatment of hypothyroidism
by: Marco Centanni, et al.
Published: (2025-07-01)

Update on therapeutic use of levothyroxine for the management of hypothyroidism during pregnancy
by: Bogumila Urgatz, et al.
Published: (2024-02-01)

Investigating the effect of levothyroxine replacement on cholesterol levels in hypothyroid patients
by: Leila Moradi, et al.
Published: (2024-06-01)

Long-term outcomes of LT4/LT3 combination treatment for persistent hypothyroid symptoms
by: Birte Nygaard, et al.
Published: (2025-03-01)

Effects of Levothyroxine and thyroid stimulating hormone on bone loss in patients with primary hypothyroidism
by: Mansoor Karimifar, et al.
Published: (2014-01-01)

BENEFICIAL EFFECTS OF LEVOTHYROXINE IN THE TREATMENT OF SUBCLINICAL HYPOTHYROIDISM
by: Mulic Mersudin, et al.
Published: (2016-12-01)

Long-term hypothyroidism in patients started on levothyroxine during pregnancy
by: Sophie Demartin, et al.
Published: (2024-06-01)

Socioeconomic influence on treatment with liothyronine and desiccated thyroid extract in Denmark
by: Jeppe Lerche la Cour, et al.
Published: (2023-01-01)

Successful Oral Levothyroxine Desensitization in a Patient with Severe Hypothyroidism Post Radioactive Iodine Therapy
by: Yi Jiang Chua, et al.
Published: (2022-07-01)

Are liquid levothyroxine formulations comparable? The LETI study
by: Elisa Gatta, et al.
Published: (2025-04-01)

Severity of Fatigue and Its Relationship with TSH before and after Levothyroxine Replacement Therapy in Patients with Primary Hypothyroidism
by: María Guadalupe Ruíz-Pacheco, et al.
Published: (2023-03-01)

Apalutamide treatment and refractory hypothyroidism: effects of apalutamide on levothyroxine metabolism
by: Florie Quattrochi, et al.
Published: (2025-09-01)

Change in levothyroxine requirements after bariatric surgery in patients with hypothyroidism
by: Garcia-Moreno Rosa Maria, et al.
Published: (2022-04-01)

Adherence to levothyroxine treatment and factors related with adherence in patients with hypothyroidism
by: Ahmet Dirikoç, et al.
Published: (2021-06-01)

Changes in Thyroid Metabolites after Liothyronine Administration: A Secondary Analysis of Two Clinical Trials That Incorporated Pharmacokinetic Data
by: Nour Diab, et al.
Published: (2022-05-01)

Association between levothyroxine supplementation for hypothyroidism in late pregnancy and risk of prematurity: a population-based cohort study
by: Maya Laham, et al.
Published: (2025-02-01)

Natural desiccated thyroid for the treatment of hypothyroidism?
by: Adrian H. Heald, et al.
Published: (2024-01-01)

P-glycoprotein polymorphism and levothyroxine bioavailability in hypothyroid patients
by: Ezgi Öztaş, et al.
Published: (2018-02-01)

Intramuscular and subcutaneous levothyroxine: success in treating refractory hypothyroidism
by: Nadia Chaudhury, et al.
Published: (2025-04-01)

Effect of levothyroxine on major adverse cardiovascular events in patients with hypothyroidism and cardiovascular disease
by: Lijia Liu, et al.
Published: (2025-08-01)

Parents’ Adherence to Medical Advices about Administering Levothyroxine Therapy to their Hypothyroid Children
by: Rihab F. Alabedi, et al.
Published: (2025-01-01)

Weekly Versus Daily Levothyroxine Tablet Replacement in Adults with Hypothyroidism
by: Harold Henrison Chiu, et al.
Published: (2022-07-01)

Effects of induced maternal hypothyroidism on the postnatal development of albino rat visual cortex and the ameliorative effect of Levothyroxine
by: Mohamed Nabil Saleh, et al.
Published: (2023-01-01)