Mechanisms of the FLASH effect: current insights and advances

Radiotherapy is a fundamental tool in cancer treatment, utilized in over 60% of cancer patients during their treatment course. While conventional radiotherapy is effective, it has limitations, including prolonged treatment durations, which extend patient discomfort, and toxicity to surrounding healt...

Full description

Bibliographic Details
Published in:	Frontiers in Cell and Developmental Biology
Main Authors:	Giulia Rosini, Esther Ciarrocchi, Beatrice D’Orsi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-05-01
Subjects:	radiotherapy ultra-high-dose rate irradiation flash cell death cancer metabolism cancer cells
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2025.1575678/full

Similar Items

Editorial: Cell death mechanisms in neurodegenerative disorders
by: Meghana Tare, et al.
Published: (2025-10-01)

The FLASH effect—an evaluation of preclinical studies of ultra-high dose rate radiotherapy
by: Josie May McGarrigle, et al.
Published: (2024-04-01)

Editorial: Multidisciplinary approaches to the FLASH radiotherapy
by: Fabio Di Martino, et al.
Published: (2024-06-01)

FLASH Radiotherapy Versus Conventional Cancer Therapy: Promises, Paradoxes and Problems
by: Stephen C. Bondy
Published: (2024-09-01)

Ultra-High Dose Rate FLASH Irradiation Induced Radio-Resistance of Normal Fibroblast Cells Can Be Enhanced by Hypoxia and Mitochondrial Dysfunction Resulting From Loss of Cytochrome C
by: Jintao Han, et al.
Published: (2021-04-01)

Mechanisms of Action in FLASH Radiotherapy: A Comprehensive Review of Physicochemical and Biological Processes on Cancerous and Normal Cells
by: James C. L. Chow, et al.
Published: (2024-05-01)

Potential effect of FLASH radiotherapy on testicular damage: a review of current evidence
by: Xiaoyu Zhi, et al.
Published: (2025-09-01)

Cancer Cells Can Exhibit a Sparing FLASH Effect at Low Doses Under Normoxic In Vitro-Conditions
by: Gabriel Adrian, et al.
Published: (2021-07-01)

Long-term toxicity and efficacy of FLASH radiotherapy in dogs with superficial malignant tumors
by: Bolette W. Gjaldbæk, et al.
Published: (2024-07-01)

Association of Cancer Stem Cell Radio-Resistance Under Ultra-High Dose Rate FLASH Irradiation With Lysosome-Mediated Autophagy
by: Gen Yang, et al.
Published: (2021-04-01)

Influence factor and mechanism of FLASH effect
by: Tingyu Feng, et al.
Published: (2025-09-01)

Randomized phase II selection trial of FLASH and conventional radiotherapy for patients with localized cutaneous squamous cell carcinoma or basal cell carcinoma: A study protocol
by: Rémy Kinj, et al.
Published: (2024-03-01)

Mitochondrial Carrier Homolog 2 Functionally Co-operates With BH3 Interacting-Domain Death Agonist in Promoting Ca2+-Induced Neuronal Injury
by: Beatrice D’Orsi, et al.
Published: (2021-10-01)

Radiobiology and treatment plan progress of FLASH radiotherapy
by: WU Xun, et al.
Published: (2023-04-01)

Translational Research in FLASH Radiotherapy—From Radiobiological Mechanisms to In Vivo Results
by: Loredana G. Marcu, et al.
Published: (2021-02-01)

Unraveling the effects of FLASH and conventional irradiation on retinal pigment epithelial cells: in vitro and in vivo studies
by: Beatrice Di Marco, et al.
Published: (2025-07-01)

The influence of beam parameters on FLASH effect
by: Binwei Lin, et al.
Published: (2025-04-01)

Gamma Irradiation for Agrifood: Non-Destructive Approaches to Study the Secondary Effects Produced in Italian Wheat Matrices
by: Rocco Carcione, et al.
Published: (2025-05-01)

FLASH radiotherapy: Research process from basic experimentation to clinical application
by: Xiaohui Wang, et al.
Published: (2021-12-01)

BOK controls ER proteostasis and physiological ER stress responses in neurons
by: Franziska Walter, et al.
Published: (2022-08-01)

Architecture, flexibility and performance of a special electron linac dedicated to Flash radiotherapy research: electronFlash with a triode gun of the centro pisano flash radiotherapy (CPFR)
by: F. Di Martino, et al.
Published: (2023-11-01)

Flash Radiotherapy: Innovative Cancer Treatment
by: James C. L. Chow, et al.
Published: (2023-06-01)

FLASH radiotherapy combined with immunotherapy: From biological mechanisms to blockbuster therapeutics
by: Yu Wang, et al.
Published: (2025-01-01)

Editorial: Harnessing the potential of FLASH: questions we must address prior to effective clinical translation
by: Per Rugaard Poulsen, et al.
Published: (2024-11-01)

Radiobiological Aspects of FLASH Radiotherapy
by: Eline Hageman, et al.
Published: (2022-09-01)

Soffrire per non dimenticare: Agency, nostalgia e lutto nella sinistra in Turchia
by: Lorenzo D’Orsi
Published: (2021-06-01)

Sorvegliare, punire, assimilare. Il collegio autoctono di Sept-Îles a Maliotenam
by: Annalisa D’Orsi
Published: (2022-12-01)

Sociologo con il virtuoso «vizio della storia»
by: Angelo d’Orsi
Published: (2002-11-01)

One Step Forward, Half Step Back: the Still Long Way to Go to End Statelessness in Madagascar
by: Cristiano d'Orsi
Published: (2023-12-01)

Policing During COVID-19: Perspectives from MET Police, UK
by: Lucy D'Orsi
Published: (2021-03-01)

Mechanisms of FLASH effect
by: Binwei Lin, et al.
Published: (2022-09-01)

Oxygen Depletion and the Role of Cellular Antioxidants in FLASH Radiotherapy: Mechanistic Insights from Monte Carlo Radiation-Chemical Modeling
by: Israth Rabeya, et al.
Published: (2025-03-01)

The evolution of FLASH radiotherapy: a bibliometric analysis
by: Shuokai Jia, et al.
Published: (2025-05-01)

A safety study of ultra‐high dose rate FLASH radiotherapy in the treatment of superficial skin tumors: study protocol of a phase I trial (ChiCTR2400080935)
by: Chengliang Yang, et al.
Published: (2025-06-01)

Feasibility study of high-power electron linac for clinical X-ray ROAD-FLASH therapy system
by: Sergey V. Kutsaev, et al.
Published: (2024-06-01)

FLASH radiotherapy at a crossroads: a bibliometric perspective on progress and challenges
by: Peng Wang, et al.
Published: (2025-08-01)

Intertrack interaction at ultra-high dose rates and its role in the FLASH effect
by: Alexander Baikalov, et al.
Published: (2023-08-01)

Leveraging the Immune Response from LIFE Biomaterial and Photon-Flash in Pre-Clinical Pancreatic Cancer Treatment
by: Michele Moreau, et al.
Published: (2025-09-01)

<i>In-Vivo</i> Dosimetry for Ultra-High Dose Rate (UHDR) Electron Beam FLASH Radiotherapy Using an Organic (Plastic), an Organic–Inorganic Hybrid and an Inorganic Point Scintillator System
by: Verdi Vanreusel, et al.
Published: (2024-09-01)

A Mathematical Model of In Vitro Cellular Uptake of Zoledronic Acid and Isopentenyl Pyrophosphate Accumulation
by: Elena Lo Presti, et al.
Published: (2022-06-01)