Simultaneous electroanalytical sensing of dopamine and epinephrine using TiO2/reduced graphene oxide nanocomposite modified glassy carbon electrode

• Published in: Nanochemistry Research
• Main Authors: Khadijeh Ghanbari, Fahime Ghorbani, Sepide Bonyadi
• Format: Article
• Language: English
• Published: Iranian Chemical Society 2021-10-01
• Subjects: electrochemical sensor, reduced graphene oxide; dopamine, epinephrine, tio2 nanoparticles
• Online Access: http://www.nanochemres.org/article_147006_7e8fd220c67ed92afc1a9b22e5df051b.pdf
• ISSN: 2538-4279; 2423-818X

In this work, a novel electrochemical sensor was introduced for simultaneous determination of dopamine (DA) and epinephrine (EP) by modifying a glassy carbon electrode (GCE) with reduced graphene oxide (RGO) and titanium dioxide (TiO2) nanoparticles. The RGO/TiO2 nanocomposite characterization was investigated by using Field emission scanning electron microscopy (FE-SEM), Elemental mapping, Fourier-transform infrared spectroscopy (FTIR), Raman spectroscopy, X-Ray diffraction analysis (XRD), and X-ray photoelectron spectroscopy (XPS). Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods were used for electrochemical measurements. Our study showed that the resultant RGO/TiO2 modified GCE is highly sensitive and selective for the simultaneous determination of DA and EP, and provided two linear responses ranges from 5-180 µM, 180-1000 µM with a detection limit of 1.3 µM for DA and two linear responses ranges from 5-20 µM and 20-1000 µM with a detection limit of 1.4 µM for EP. Also, the electrochemical oxidation of DA and EP was well recovered in pharmaceutical formulations.