Phage Cocktails with Daptomycin and Ampicillin Eradicates Biofilm-Embedded Multidrug-Resistant <i>Enterococcus faecium</i> with Preserved Phage Susceptibility
Multidrug-resistant (MDR) <i>Enterococcus faecium</i> is a challenging nosocomial pathogen known to colonize medical device surfaces and form biofilms. Bacterio (phages) may constitute an emerging anti-infective option for refractory, biofilm-mediated infections. This study evaluates eig...
| Published in: | Antibiotics |
|---|---|
| Main Authors: | Ashlan J. Kunz Coyne, Kyle Stamper, Razieh Kebriaei, Dana J. Holger, Amer El Ghali, Taylor Morrisette, Biswajit Biswas, Melanie Wilson, Michael V. Deschenes, Gregory S. Canfield, Breck A. Duerkop, Cesar A. Arias, Michael J. Rybak |
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
|
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/11/9/1175 |
Similar Items
Phage-Antibiotic Cocktail Rescues Daptomycin and Phage Susceptibility against Daptomycin-Nonsusceptible Enterococcus faecium in a Simulated Endocardial Vegetation Ex Vivo Model
by: Ashlan J. Kunz Coyne, et al.
Published: (2023-08-01)
by: Ashlan J. Kunz Coyne, et al.
Published: (2023-08-01)
Synergistic bactericidal effects of phage-enhanced antibiotic therapy against MRSA biofilms
by: Ashlan J. Kunz Coyne, et al.
Published: (2024-04-01)
by: Ashlan J. Kunz Coyne, et al.
Published: (2024-04-01)
It takes two to tango: Preserving daptomycin efficacy against daptomycin-resistant MRSA using daptomycin-phage co-therapy
by: Casey L. Madison, et al.
Published: (2024-12-01)
by: Casey L. Madison, et al.
Published: (2024-12-01)
Optimization of Phage-Antibiotic Combinations against Staphylococcus aureus Biofilms
by: Razieh Kebriaei, et al.
Published: (2023-06-01)
by: Razieh Kebriaei, et al.
Published: (2023-06-01)
Development of a Bacteriophage Cocktail to Constrain the Emergence of Phage-Resistant Pseudomonas aeruginosa
by: Yuhui Yang, et al.
Published: (2020-03-01)
by: Yuhui Yang, et al.
Published: (2020-03-01)
The Use of Phage Cocktail and Various Antibacterial Agents in Combination to Prevent the Emergence of Phage Resistance
by: Hoang Minh Duc, et al.
Published: (2023-06-01)
by: Hoang Minh Duc, et al.
Published: (2023-06-01)
Evaluation of Bacteriophage-Antibiotic Combination Therapy for Biofilm-Embedded MDR <i>Enterococcus faecium</i>
by: Katherine Lev, et al.
Published: (2022-03-01)
by: Katherine Lev, et al.
Published: (2022-03-01)
Efficiency, cytotoxicity, and survivability evaluation of Salmonella phage cocktail against Salmonella derived from broiler sources
by: Wattana Pelyuntha, et al.
Published: (2025-02-01)
by: Wattana Pelyuntha, et al.
Published: (2025-02-01)
Phage-Encoded Endolysins
by: Fatma Abdelrahman, et al.
Published: (2021-01-01)
by: Fatma Abdelrahman, et al.
Published: (2021-01-01)
Daptomycin for highly resistant Enterococcus faecium infection
by: Christiane Rosin, et al.
Published: (2012-06-01)
by: Christiane Rosin, et al.
Published: (2012-06-01)
Exploring synergistic and antagonistic interactions in phage-antibiotic combinations against ESKAPE pathogens
by: Ashlan J. Kunz Coyne, et al.
Published: (2024-10-01)
by: Ashlan J. Kunz Coyne, et al.
Published: (2024-10-01)
In vivo therapeutic evaluation of phage cocktail and probiotic in reducing Salmonella infection in Broilers
by: TARUN KUMAR, et al.
Published: (2023-12-01)
by: TARUN KUMAR, et al.
Published: (2023-12-01)
Broad host range phages target global Clostridium perfringens bacterial strains and clear infection in five-strain model systems
by: Anisha M. Thanki, et al.
Published: (2024-05-01)
by: Anisha M. Thanki, et al.
Published: (2024-05-01)
Utilizing the effectiveness of phage cocktail to combat Shigella and Salmonella infections and their polymicrobial biofilm control activity
by: Payel Mondal, et al.
Published: (2025-10-01)
by: Payel Mondal, et al.
Published: (2025-10-01)
Designing phage cocktails to combat the emergence of bacteriophage-resistant mutants in multidrug-resistant Klebsiella pneumoniae
by: Seongjun Yoo, et al.
Published: (2024-01-01)
by: Seongjun Yoo, et al.
Published: (2024-01-01)
Effect of Phage-Antibiotic Synergism (PAS) in increasing antibiotic inhibition of bacteria caused of foodborne diseases
by: Mochammad Iqbal, et al.
Published: (2020-05-01)
by: Mochammad Iqbal, et al.
Published: (2020-05-01)
Phage Therapy: Concept to Cure
by: Eric Christopher Keen
Published: (2012-07-01)
by: Eric Christopher Keen
Published: (2012-07-01)
Editorial: Insights in phage biology: 2021
by: Adelaide Almeida
Published: (2022-10-01)
by: Adelaide Almeida
Published: (2022-10-01)
Phages for Biofilm Removal
by: Celia Ferriol-González, et al.
Published: (2020-05-01)
by: Celia Ferriol-González, et al.
Published: (2020-05-01)
Isolation and Characterization of Lytic Bacteriophages Active against Clinical Strains of <i>E. coli</i> and Development of a Phage Antimicrobial Cocktail
by: Pavel Alexyuk, et al.
Published: (2022-10-01)
by: Pavel Alexyuk, et al.
Published: (2022-10-01)
Targeted dual-receptor phage cocktail against Cronobacter sakazakii: insights into phage-host interactions and resistance mechanisms
by: Seongok Kim, et al.
Published: (2024-12-01)
by: Seongok Kim, et al.
Published: (2024-12-01)
Phage Therapy as an Alternative to Antibiotics: Harnessing Phages in Oral Medicine
by: Pospiszyl Filip, et al.
Published: (2025-07-01)
by: Pospiszyl Filip, et al.
Published: (2025-07-01)
Editorial: Standards in personalized phage therapy: from phage collection to phage production
by: Saija Kiljunen, et al.
Published: (2024-03-01)
by: Saija Kiljunen, et al.
Published: (2024-03-01)
ONCE MORE ABOUT PHAGE THERAPY: WHAT IS RIGHT, AND WHAT IS NOT
by: V. M. Popova, et al.
Published: (2016-12-01)
by: V. M. Popova, et al.
Published: (2016-12-01)
Tackling Intrinsic Antibiotic Resistance in <i>Serratia marcescens</i> with a Combination of Ampicillin/Sulbactam and Phage SALSA
by: Lorenz Weber, et al.
Published: (2020-07-01)
by: Lorenz Weber, et al.
Published: (2020-07-01)
Study of bacterial susceptibility to antibiotic and phage combinations: a literature review
by: Olga E. Punchenko, et al.
Published: (2024-11-01)
by: Olga E. Punchenko, et al.
Published: (2024-11-01)
Phascinating Phages
by: Marek Straka, et al.
Published: (2022-07-01)
by: Marek Straka, et al.
Published: (2022-07-01)
Combined Forces Against Bacteria: Phages and Antibiotics
by: Shima Afrasiabi, et al.
Published: (2025-07-01)
by: Shima Afrasiabi, et al.
Published: (2025-07-01)
The current state of phage therapy in livestock and companion animals
by: Youbin Choi, et al.
Published: (2024-01-01)
by: Youbin Choi, et al.
Published: (2024-01-01)
The Current Landscape of Phage–Antibiotic Synergistic (PAS) Interactions
by: Brittany S. I. Supina, et al.
Published: (2025-05-01)
by: Brittany S. I. Supina, et al.
Published: (2025-05-01)
Efficacy of Erwinia amylovora and Xanthomonas campestris pv campestris phages to control fire blight and black rot in vivo
by: Gloria Vique, et al.
Published: (2025-07-01)
by: Gloria Vique, et al.
Published: (2025-07-01)
Phage‐Antibiotic Combinations for Pseudomonas: Successes in the Clinic and In Vitro Tenuously Connected
by: Rabia Fatima, et al.
Published: (2025-07-01)
by: Rabia Fatima, et al.
Published: (2025-07-01)
Phage Therapy in Veterinary Medicine
by: Rosa Loponte, et al.
Published: (2021-04-01)
by: Rosa Loponte, et al.
Published: (2021-04-01)
A diverse set of Enterococcus-infecting phage provides insight into phage host-range determinants
by: Alhassan M. Alrafaie, et al.
Published: (2024-09-01)
by: Alhassan M. Alrafaie, et al.
Published: (2024-09-01)
Development and characterization of a bacteriophage cocktail with high lytic efficacy against field-isolated Salmonella enterica
by: Matías Aguilera, et al.
Published: (2023-12-01)
by: Matías Aguilera, et al.
Published: (2023-12-01)
Temperate phage-antibiotic synergy is widespread—extending to Pseudomonas—but varies by phage, host strain, and antibiotic pairing
by: Rabia Fatima, et al.
Published: (2025-02-01)
by: Rabia Fatima, et al.
Published: (2025-02-01)
Bacteriophage Treatment Induces Phenotype Switching and Alters Antibiotic Resistance of ESBL <i>Escherichia coli</i>
by: Árpád Rózsa, et al.
Published: (2025-01-01)
by: Árpád Rózsa, et al.
Published: (2025-01-01)
Exacerbations of Chronic Rhinosinusitis—Microbiology and Perspectives of Phage Therapy
by: Joanna Szaleniec, et al.
Published: (2019-10-01)
by: Joanna Szaleniec, et al.
Published: (2019-10-01)
Interaction with a phage gene underlie costs of a β-lactamase
by: Huei-Yi Lai, et al.
Published: (2024-02-01)
by: Huei-Yi Lai, et al.
Published: (2024-02-01)
Effect of an antibiotic and a probiotic on phage communities in the swine gut microbiota
by: Éléonore Lemieux, et al.
Published: (2025-09-01)
by: Éléonore Lemieux, et al.
Published: (2025-09-01)
Similar Items
-
Phage-Antibiotic Cocktail Rescues Daptomycin and Phage Susceptibility against Daptomycin-Nonsusceptible Enterococcus faecium in a Simulated Endocardial Vegetation Ex Vivo Model
by: Ashlan J. Kunz Coyne, et al.
Published: (2023-08-01) -
Synergistic bactericidal effects of phage-enhanced antibiotic therapy against MRSA biofilms
by: Ashlan J. Kunz Coyne, et al.
Published: (2024-04-01) -
It takes two to tango: Preserving daptomycin efficacy against daptomycin-resistant MRSA using daptomycin-phage co-therapy
by: Casey L. Madison, et al.
Published: (2024-12-01) -
Optimization of Phage-Antibiotic Combinations against Staphylococcus aureus Biofilms
by: Razieh Kebriaei, et al.
Published: (2023-06-01) -
Development of a Bacteriophage Cocktail to Constrain the Emergence of Phage-Resistant Pseudomonas aeruginosa
by: Yuhui Yang, et al.
Published: (2020-03-01)
