Genome-guided discovery of cancer therapeutic targets
Summary: The success of precision oncology—which aims to match the right therapies to the right patients based on molecular status—is predicated on a robust pipeline of molecular targets against which therapies can be developed. Recent advances in genomics and functional genetics have enabled the un...
| Published in: | Cell Reports |
|---|---|
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-08-01
|
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723009890 |
| _version_ | 1850295219453427712 |
|---|---|
| author | Prathyusha Konda Simon Garinet Eliezer M. Van Allen Srinivas R. Viswanathan |
| author_facet | Prathyusha Konda Simon Garinet Eliezer M. Van Allen Srinivas R. Viswanathan |
| author_sort | Prathyusha Konda |
| collection | DOAJ |
| container_title | Cell Reports |
| description | Summary: The success of precision oncology—which aims to match the right therapies to the right patients based on molecular status—is predicated on a robust pipeline of molecular targets against which therapies can be developed. Recent advances in genomics and functional genetics have enabled the unbiased discovery of novel molecular targets at scale. We summarize the promise and challenges in integrating genomic and functional genetic landscapes of cancer to establish the next generation of cancer targets. |
| format | Article |
| id | doaj-art-e2a9b918547f404dbffa2454a9fc8ff9 |
| institution | Directory of Open Access Journals |
| issn | 2211-1247 |
| language | English |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| spelling | doaj-art-e2a9b918547f404dbffa2454a9fc8ff92025-08-19T23:33:36ZengElsevierCell Reports2211-12472023-08-0142811297810.1016/j.celrep.2023.112978Genome-guided discovery of cancer therapeutic targetsPrathyusha Konda0Simon Garinet1Eliezer M. Van Allen2Srinivas R. Viswanathan3Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USADepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USADepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USADepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA; Corresponding authorSummary: The success of precision oncology—which aims to match the right therapies to the right patients based on molecular status—is predicated on a robust pipeline of molecular targets against which therapies can be developed. Recent advances in genomics and functional genetics have enabled the unbiased discovery of novel molecular targets at scale. We summarize the promise and challenges in integrating genomic and functional genetic landscapes of cancer to establish the next generation of cancer targets.http://www.sciencedirect.com/science/article/pii/S2211124723009890CP: Cancer |
| spellingShingle | Prathyusha Konda Simon Garinet Eliezer M. Van Allen Srinivas R. Viswanathan Genome-guided discovery of cancer therapeutic targets CP: Cancer |
| title | Genome-guided discovery of cancer therapeutic targets |
| title_full | Genome-guided discovery of cancer therapeutic targets |
| title_fullStr | Genome-guided discovery of cancer therapeutic targets |
| title_full_unstemmed | Genome-guided discovery of cancer therapeutic targets |
| title_short | Genome-guided discovery of cancer therapeutic targets |
| title_sort | genome guided discovery of cancer therapeutic targets |
| topic | CP: Cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723009890 |
| work_keys_str_mv | AT prathyushakonda genomeguideddiscoveryofcancertherapeutictargets AT simongarinet genomeguideddiscoveryofcancertherapeutictargets AT eliezermvanallen genomeguideddiscoveryofcancertherapeutictargets AT srinivasrviswanathan genomeguideddiscoveryofcancertherapeutictargets |