Genome-guided discovery of cancer therapeutic targets

Summary: The success of precision oncology—which aims to match the right therapies to the right patients based on molecular status—is predicated on a robust pipeline of molecular targets against which therapies can be developed. Recent advances in genomics and functional genetics have enabled the un...

Full description

Bibliographic Details
Published in:	Cell Reports
Main Authors:	Prathyusha Konda, Simon Garinet, Eliezer M. Van Allen, Srinivas R. Viswanathan
Format:	Article
Language:	English
Published:	Elsevier 2023-08-01
Subjects:	CP: Cancer
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124723009890

Similar Items

Integrative genomic identification of therapeutic targets for pancreatic cancer
by: Jimmy A. Guo, et al.
Published: (2025-09-01)

Epigenomic signatures of sarcomatoid differentiation to guide the treatment of renal cell carcinoma
by: Talal El Zarif, et al.
Published: (2024-06-01)

CD84 as a therapeutic target for breaking immune tolerance in triple-negative breast cancer
by: Stav Rabani, et al.
Published: (2024-11-01)

Tumor-induced metabolic immunosuppression: Mechanisms and therapeutic targets
by: Jean-Ehrland Ricci
Published: (2025-01-01)

Targeting both the enzymatic and non-enzymatic functions of DHODH as a therapeutic vulnerability in c-Myc-driven cancer
by: Qiang Zhang, et al.
Published: (2025-03-01)

The MYCN 5′ UTR as a therapeutic target in neuroblastoma
by: Marina P. Volegova, et al.
Published: (2024-05-01)

Neuroimmune axis in gastrointestinal cancers: From mechanisms to therapeutic breakthrough
by: Yixuan Zhang, et al.
Published: (2025-08-01)

Amino acids in cancer: Understanding metabolic plasticity and divergence for better therapeutic approaches
by: Linda K. Do, et al.
Published: (2025-04-01)

Targeting the non-coding genome and temozolomide signature enables CRISPR-mediated glioma oncolysis
by: I-Li Tan, et al.
Published: (2023-11-01)

Targeting VCP potentiates immune checkpoint therapy for colorectal cancer
by: Fang Wang, et al.
Published: (2023-11-01)

A therapeutically targetable positive feedback loop between lnc-HLX-2-7, HLX, and MYC that promotes group 3 medulloblastoma
by: Keisuke Katsushima, et al.
Published: (2024-03-01)

Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma
by: Tianyi Ye, et al.
Published: (2024-05-01)

Deciphering genomic evolution of metastatic organotropism with 535 paired primary lung cancers and metastases
by: Duo Xie, et al.
Published: (2025-10-01)

Unraveling the nexus: Genomic instability and metabolism in cancer
by: Vaibhavi Gujar, et al.
Published: (2025-04-01)

Targeting CDK2 for cancer therapy
by: Erik S. Knudsen, et al.
Published: (2025-08-01)

Spatial and clonality-resolved 3D cancer genome alterations reveal enhancer-hijacking as a potential prognostic marker for colorectal cancer
by: Kyukwang Kim, et al.
Published: (2023-07-01)

Transcription factor ZNF263 enhances EGFR-targeted therapeutic response and reduces residual disease in lung adenocarcinoma
by: Jiaqi Liang, et al.
Published: (2024-02-01)

MYO10 regulates genome stability and cancer inflammation through mediating mitosis
by: Franklin Mayca Pozo, et al.
Published: (2023-05-01)

JAML immunotherapy targets recently activated tumor-infiltrating CD8+ T cells
by: Simon Eschweiler, et al.
Published: (2023-02-01)

Genome-wide characterization of extrachromosomal circular DNA in breast cancer and its potential role in carcinogenesis and cancer progression
by: Zhimei Sheng, et al.
Published: (2024-11-01)

Myeloid-lineage-specific membrane protein LRRC25 suppresses immunity in solid tumor and is a potential cancer immunotherapy checkpoint target
by: Guorong Zhang, et al.
Published: (2025-05-01)

Comparing neoantigen cancer vaccines and immune checkpoint therapy unveils an effective vaccine and anti-TREM2 macrophage-targeting dual therapy
by: Sunita Keshari, et al.
Published: (2024-11-01)

Mutant TP53 switches therapeutic vulnerability during gastric cancer progression within interleukin-6 family cytokines
by: Anne Huber, et al.
Published: (2024-08-01)

The genomic and evolutionary landscapes of anaplastic thyroid carcinoma
by: Peter Y.F. Zeng, et al.
Published: (2024-03-01)

Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer
by: Alok K. Mishra, et al.
Published: (2024-04-01)

FRMD8 targets both CDK4 activation and RB degradation to suppress colon cancer growth
by: Miao Yu, et al.
Published: (2023-08-01)

Pseudouridine synthase 1-targeted therapy activates antiviral immunity to boost cancer immunotherapy
by: Fan Wang, et al.
Published: (2025-09-01)

Genome-wide profiling of transcription factor activity in primary liver cancer using single-cell ATAC sequencing
by: Amanda J. Craig, et al.
Published: (2023-11-01)

Targeting an essential viral oncoprotein with an IL-7-enhanced mRNA vaccine induces durable immunity to Merkel cell carcinoma
by: Alexander Frey, et al.
Published: (2025-10-01)

Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-β axis
by: Xinyue Ma, et al.
Published: (2023-08-01)

An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma
by: Stephanie M. Casillo, et al.
Published: (2024-01-01)

Dark force rising: Reawakening and targeting of fetal-like stem cells in colorectal cancer
by: Sigrid K. Fey, et al.
Published: (2024-06-01)

Targeting FOXA1 and FOXA2 disrupts the lineage-specific oncogenic output program in prostate cancer
by: Nicolo Formaggio, et al.
Published: (2025-10-01)

Cytosolic DNA composition is determined by genomic instability mechanism and regulates dendritic cell-mediated anti-tumor immunity
by: Shayla R. Mosley, et al.
Published: (2025-02-01)

Engineering CD276/B7-H3-targeted antibody-drug conjugates with enhanced cancer-eradicating capability
by: Yang Feng, et al.
Published: (2023-12-01)

Carvedilol sensitizes chemotherapy by targeting STING to boost anti-tumor immunity
by: Yifang Dang, et al.
Published: (2025-05-01)

Targeting protein tyrosine phosphatases for CDK6-induced immunotherapy resistance
by: Xueliang Gao, et al.
Published: (2023-04-01)

Engineering of dendritic cell bispecific extracellular vesicles for tumor-targeting immunotherapy
by: Fang Xu, et al.
Published: (2023-10-01)

Targeting the UFL1-PARP1 axis amplifies anti-tumor immunity
by: Wenjing Song, et al.
Published: (2025-10-01)

Multi-level functional genomics reveals molecular and cellular oncogenicity of patient-based 3′ untranslated region mutations
by: Samantha L. Schuster, et al.
Published: (2023-08-01)