Single cohesin molecules generate force by two distinct mechanisms
Abstract Spatial organization of DNA is facilitated by cohesin protein complexes that move on DNA and extrude DNA loops. How cohesin works mechanistically as a molecular machine is poorly understood. Here, we measure mechanical forces generated by conformational changes in single cohesin molecules....
| 發表在: | Nature Communications |
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| Main Authors: | , , , |
| 格式: | Article |
| 語言: | 英语 |
| 出版: |
Nature Portfolio
2023-07-01
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| 在線閱讀: | https://doi.org/10.1038/s41467-023-39696-8 |