Cancer lineage-specific regulation of YAP responsive elements revealed through large-scale functional epigenomic screens

Abstract YAP is a key transcriptional co-activator of TEADs, it regulates cell growth and is frequently activated in cancer. In Malignant Pleural Mesothelioma (MPM), YAP is activated by loss-of-function mutations in upstream components of the Hippo pathway, while, in Uveal Melanoma (UM), YAP is acti...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Inês A. M. Barbosa, Rajaraman Gopalakrishnan, Samuele Mercan, Thanos P. Mourikis, Typhaine Martin, Simon Wengert, Caibin Sheng, Fei Ji, Rui Lopes, Judith Knehr, Marc Altorfer, Alicia Lindeman, Carsten Russ, Ulrike Naumann, Javad Golji, Kathleen Sprouffske, Louise Barys, Luca Tordella, Dirk Schübeler, Tobias Schmelzle, Giorgio G. Galli
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-07-01
Online Access:	https://doi.org/10.1038/s41467-023-39527-w