Anti-inflammatory and anti-nociceptive effects of hydroalchoholic extract of Nepeta menthoides on pain in aerial parts in male mice
Introduction: The application of herbal plants instead of synthetic drugs has been increasing in recent years because of their lower side-effects and high varieties of efficient components. An investigation on anti-nociceptive and anti-inflammatory effects of hydroalcoholic extract of Nepeta menth...
| Published in: | فصلنامه دانشگاه علوم پزشکی جهرم |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | Persian |
| Published: |
Jahrom University of Medical Sciences
2013-11-01
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| Subjects: | |
| Online Access: | http://jmj.jums.ac.ir/browse.php?a_id=252&slc_lang=en&sid=1&ftxt=1 |
| Summary: | Introduction:
The application of herbal plants instead of synthetic drugs has been increasing in recent years because of their lower side-effects and high varieties of efficient components. An investigation on anti-nociceptive and anti-inflammatory effects of hydroalcoholic extract of Nepeta menthoides seems to be necessary due to the existence of its components.
Materials and Methods:
This study was done on 224 NMRI male mice weighing 20-25 g. Xylene-induced ear edema and Formalin test were used for demonstrating its anti-inflammatory and anti-nociceptive effects.
Results:
The hydroalcholic extract had no toxic effect. This study showed that Nepeta menthoides aerial parts have anti-inflammatory effect at all doses, particularly at dose of 2800 mg/kg and significantly decreased nociception in chronic phases. The dose of 2800 mg/kg had the most anti-nociceptive effect in chronic phases. Meanwhile, in the immersion test, nociception decreased at a dose of 1400 mg/kg significantly.
Conclusion:
Hydroalcoholic extract of Nepeta menthoides has anti-nociceptive and anti-inflammatory effects. These effects might be due to its Nepetalactone and 1,8 cineole components. |
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| ISSN: | 2008-7993 2008-8442 |