Ribosome•RelA structures reveal the mechanism of stringent response activation

Stringent response is a conserved bacterial stress response underlying virulence and antibiotic resistance. RelA/SpoT-homolog proteins synthesize transcriptional modulators (p)ppGpp, allowing bacteria to adapt to stress. RelA is activated during amino-acid starvation, when cognate deacyl-tRNA binds...

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發表在:	eLife
Main Authors:	Anna B Loveland, Eugene Bah, Rohini Madireddy, Ying Zhang, Axel F Brilot, Nikolaus Grigorieff, Andrei A Korostelev
格式:	Article
語言:	英语
出版:	eLife Sciences Publications Ltd 2016-07-01
主題:	RelA ribosome stringent response cryo-EM cognate tRNA decoding
在線閱讀:	https://elifesciences.org/articles/17029