Synthesis, Characterization and Biological Activity of Novel Cu(II) Complexes of 6-Methyl-2-Oxo-1,2-Dihydroquinoline-3-Carbaldehyde-4n-Substituted Thiosemicarbazones

Three new 6-methyl-2-oxo-1,2-dihydroquinoline-3-carbaldehyde-thiosemicarbazones-N-4-substituted pro-ligands and their Cu(II) complexes (<b>1</b>, -NH<sub>2</sub>; <b>2</b>, -NHMe; <b>3</b>, -NHEt) have been prepared and characterized. In both the X-ray...

Full description

Bibliographic Details
Published in:	Molecules
Main Authors:	Eswaran Ramachandran, Valentina Gandin, Roberta Bertani, Paolo Sgarbossa, Karuppannan Natarajan, Nattamai S. P. Bhuvanesh, Alfonso Venzo, Alfonso Zoleo, Mirto Mozzon, Alessandro Dolmella, Alberto Albinati, Carlo Castellano, Nuno Reis Conceição, M. Fátima C. Guedes da Silva, Cristina Marzano
Format:	Article
Language:	English
Published:	MDPI AG 2020-04-01
Subjects:	copper thiosemicarbazones complexes X ray crystal structure cytotoxicity in 3D spheroids EPR and electrochemical measurements TEM images
Online Access:	https://www.mdpi.com/1420-3049/25/8/1868

Similar Items

Complexes of 3dn Metal Ions with Thiosemicarbazones: Synthesis and Antimicrobial Activity
by: Tudor Rosu, et al.
Published: (2007-04-01)

Synthesis and Characterization of Amine-Functionalized Thiosemicarbazone Cyclopalladated Compounds
by: Francisco Reigosa, et al.
Published: (2021-11-01)

Synthesis, Anticholinesterase and Antioxidant Activity of Thiosemicarbazone Derivatives
by: Ulviye Acar Çevik, et al.
Published: (2024-09-01)

Solution Equilibrium Studies on Salicylidene Aminoguanidine Schiff Base Metal Complexes: Impact of the Hybridization with L-Proline on Stability, Redox Activity and Cytotoxicity
by: Orsolya Dömötör, et al.
Published: (2022-03-01)

Conformational and Functional Properties of the Bioactive Thiosemicarbazone and Thiocarbohydrazone Compounds
by: Nikitas Georgiou, et al.
Published: (2025-08-01)

Synthesis and Structural Characterization of Fluorinated Thiosemicarbazones
by: Hugo Torrens, et al.
Published: (2013-10-01)

Preliminary Evaluation of HSA and DNA Interactions with Indole-Thiosemicarbazone Compounds and Molecular Docking Studies
by: Keriolaine Lima dos Santos, et al.
Published: (2025-05-01)

Electrochemical Behavior of Some Substituted Thiosemicarbazones and their Reaction Products with Tetracyanoethylene
by: S.A.M. Refaey, A.A. Hassan and H.S. Shehata
Published: (2008-03-01)

Design and Fabrication of Heterojunctions of Thiosemicarbazones and Metallic Nanoparticles in Search of Their Medicinal Activity
by: Ekhlakh Veg, et al.
Published: (2024-05-01)

Synthesis and Bioactivity of Thiosemicarbazones Containing Adamantane Skeletons
by: Van Hien Pham, et al.
Published: (2020-01-01)

Unsymmetrical Bis(thiosemicarbazone) Ligands and Their Nickel(II) Complexes: Synthesis, Characterization and Photocatalytic Activity
by: Rodrigo Burón, et al.
Published: (2025-01-01)

Design, Synthesis, Structural Insights, Tyrosinase Inhibition, and Sun Protection Factor of New Thiosemicarbazone Derivatives
by: Sebastiano Masuri, et al.
Published: (2024-11-01)

In silico prediction of ADMET parameters and in vitro evaluation of antioxidant and cytotoxic activities promoted by indole-thiosemicarbazone compounds
by: KERIOLAINE L. DOS SANTOS, et al.
Published: (2024-06-01)

Thiosemicarbazone–based highly selective potentiometric sensor for the determination of copper(II) ions
by: Muhammed Elik, et al.
Published: (2025-01-01)

Design and Fabrication of Heterojunctions of Thiosemicarbazones and Metal Oxide Nanoparticles in Search of Their Medicinal Activity
by: Ekhlakh Veg, et al.
Published: (2024-09-01)

A Novel Heterocyclic Thiosemicarbazone: Synthesis, Characterization and Preliminary Sensing Studies for Ions
by: Maria Lene F. Jardim, et al.
Published: (2021-11-01)

Tripeptides conjugated with thiosemicarbazones: new inhibitors of tyrosinase for cosmeceutical use
by: Patrycja Ledwoń, et al.
Published: (2023-12-01)

The Effect of the Serum Amino Acid Levels Thiosemicarbazone Derivatives and its Metal Complexes on Rats
by: Mustafa Karatepe, et al.
Published: (2013-06-01)

Synthesis, In Silico Study, and Anti-Cancer Activity of Thiosemicarbazone Derivatives
by: Belay Zeleke Sibuh, et al.
Published: (2021-10-01)

A review of recent research on the antimicrobial activities of thiosemicarbazone-based compounds
by: Gürsel Korkmaz
Published: (2024-04-01)

X-ray Diffraction Study of Fluorine-Functionalized Thiosemicarbazones and Cyclometallated Compounds
by: Marcos Rúa-Sueiro, et al.
Published: (2022-01-01)

Copper thiosemicarbazone modified electrode for hydrazine electrocatalytic oxidation
by: Marichelvam Thamaraichelvan, et al.
Published: (2023-12-01)

Some Biological Applications and Mechanistic Insights of Benzaldehyde‐Substituted Thiosemicarbazones and Their Metal Complexes: A Review
by: Ekhlakh Veg, et al.
Published: (2025-04-01)

Synthesis, Characterization, and Cytotoxicity Studies of N-(4-Methoxybenzyl) Thiosemicarbazone Derivatives and Their Ruthenium(II)-<i>p</i>-cymene Complexes
by: Mónica Martínez-Estévez, et al.
Published: (2022-11-01)

Designing a Phosphino-Thiosemicarbazone Ligand Capable of Stabilizing Coinage Metal Ions
by: Isabel Velo-Heleno, et al.
Published: (2022-11-01)

Synthesis, Cytotoxic and Antimalarial Activities of Benzoyl Thiosemicarbazone Analogs of Isoquinoline and Related Compounds
by: Somsak Ruchirawat, et al.
Published: (2010-02-01)

Synthesis and X-ray Diffraction Study of thiosemicarbazone Palladacycles with dppm
by: Marcos Rúa-Sueiro, et al.
Published: (2021-01-01)

Kinetic Insights into the Antioxidant Effect of Isatin-Thiosemicarbazone in Biodiesel Blends
by: Nalan Türköz Karakullukçu, et al.
Published: (2024-07-01)

Functionalizing Thiosemicarbazones for Covalent Conjugation
by: Johannes Hohnsen, et al.
Published: (2024-08-01)

Thiosemicarbazone-Based Compounds: A Promising Scaffold for Developing Antibacterial, Antioxidant, and Anticancer Therapeutics
by: Agnieszka Czylkowska, et al.
Published: (2024-12-01)

Synthesis and comprehensive characterization with anticancer activity assessment of salicylaldehyde and 2-acetylphenol based chitosan thiosemicarbazones and their copper(II) complexes
by: Hari Sharan Adhikari, et al.
Published: (2024-06-01)

Antitrypanosomal Activity of Novel Benzaldehyde-Thiosemicarbazone Derivatives from Kaurenoic Acid †
by: Cecília M. A. de Oliveira, et al.
Published: (2011-01-01)

Design, Synthesis and Structural Characterization of a Novel Asymmetric Hydrazone-Thiosemicarbazone Ligand with the Aim of Obtaining Interesting Metallosupramolecular Architectures
by: Sandra Fernández-Fariña, et al.
Published: (2021-11-01)

Design, synthesis and antiproliferative evaluation of new acridine-thiosemicarbazone derivatives as topoisomerase IIα inhibitors
by: Gleyton Leonel Silva Sousa, et al.
Published: (2024-01-01)

Conformational Properties and Putative Bioactive Targets for Novel Thiosemicarbazone Derivatives
by: Nikitas Georgiou, et al.
Published: (2022-07-01)

Design, Synthesis and Characterization of a Bicompartmental <i>bis</i>thiosemicarbazone Ligand
by: Isabel Velo-Heleno, et al.
Published: (2023-11-01)

A Review On Organotin(Iv) Thiosemicarbazone Complexes, Synthesis, Characterization And Biological Activity
by: Rawnaq B. Jimaa, et al.
Published: (2021-12-01)

Discovery of novel isatin-based thiosemicarbazones: synthesis, antibacterial, antifungal, and antimycobacterial screening
by: Maryam Hassan, et al.
Published: (2020-01-01)

Synthesis, Identification, and anti-cancer Evaluation of Some heterocyclic Chitosan-Thiosemicarbazones compounds and their nickle (II) complexes
by: Mohsin Omar Mohammed, et al.
Published: (2024-12-01)

Spectroscopic, DFT, anti-bacterial, and in-silico investigations of novel semicarbazone and thiosemicarbazone synthesised from asymmetrical chalcones
by: Nikita Sharma, et al.
Published: (2025-04-01)