Intrahepatic cholestasis of pregnancy: Changes in maternal-fetal bile acid balance and improvement by ursodeoxycholic acid

Intrahepatic cholestasis of pregnancy (ICP) is a disease characterized by generalized pruritus and biochemical cholestasis that appears typically during the last trimester of gestation. The most predictive and accurate markers for diagnosis and follow-up of ICP are increased total bile acid levels (...

Full description

Bibliographic Details
Published in:	Annals of Hepatology
Main Author:	Dora Brites, PhD
Format:	Article
Language:	English
Published:	Elsevier 2002-01-01
Subjects:	Cholestasis Pregnancy Ursodeoxycholic acid Bile acid
Online Access:	http://www.sciencedirect.com/science/article/pii/S166526811932188X

Similar Items

Gradual dosing of ursodeoxycholic acid in mothers with intrahepatic cholestasis of pregnancy may improve composite neonatal outcome
by: Amir Hamud, et al.
Published: (2024-05-01)

Bile Acids in Intrahepatic Cholestasis of Pregnancy
by: Maciej Majsterek, et al.
Published: (2022-11-01)

Obstetric outcome of elevated total serum bile acid levels in women with intrahepatic cholestasis of pregnancy
by: Vineeta Gupta, et al.
Published: (2023-02-01)

Pregnancy outcomes following antenatal screening for intrahepatic cholestasis of pregnancy (ICP)
by: Chidera Nneji Obiegbusi, et al.
Published: (2023-11-01)

Intrahepatic Cholestasis of Pregnancy: Diagnosis, Management, and Future Directions—A Review of the Literature
by: Kamil Jasak, et al.
Published: (2025-08-01)

Ursodeoxycholic acid to reduce adverse perinatal outcomes for intrahepatic cholestasis of pregnancy: the PITCHES RCT
by: Lucy C Chappell, et al.
Published: (2020-12-01)

Effect of Ursodeoxycholic Acid Alone Verses Ursodeoxycholic Acid and Rifampicin in Obstetric Cholestasis
by: Ayesha Amjad, et al.
Published: (2025-07-01)

A Clinical & Experimental Obstetrics and Gynecology survey on ursodeoxycholic treatment of intrahepatic cholestasis of pregnancy: scholars’ opinion
by: Caroline Ovadia, et al.
Published: (2021-12-01)

Are Postprandial Bile Acid Levels Helpful in Predicting Perinatal Complications in Patients with Intrahepatic Cholestasis of Pregnancy?
by: Kudret Erkenekli, et al.
Published: (2015-06-01)

Evaluating the Effect of Bile Acid Levels on Maternal and Perinatal Outcomes in Intrahepatic Cholestasis of Pregnancy: A Retrospective Study
by: Petra Gregorc, et al.
Published: (2025-08-01)

Determining Urinary Bile Acid Profiles to Predict Maternal and Neonatal Outcomes in Patients with Intrahepatic Cholestasis of Pregnancy
by: Ping You, et al.
Published: (2025-03-01)

The effects of ursodeoxycholic acid on sepsis-induced cholestasis management in an animal model
by: Randa H. Ainosah, MSc, et al.
Published: (2020-08-01)

High-fat diets enhance and delay ursodeoxycholic acid absorption but elevate circulating hydrophobic bile salts
by: Liang Huang, et al.
Published: (2023-04-01)

THE ROLE OF URSODEOXYCHOLIC ACID IN THE TREATMENT OF CHRONIC VIRAL HEPATITIS
by: R. G. MYAZIN
Published: (2017-05-01)

Bile Acids in Cholestasis and its Treatment
by: Juan Pablo Arab, et al.
Published: (2017-11-01)

Intrahepatic cholestasis of pregnancy: results of a tertiary referral center
by: Onur Karaaslan, et al.
Published: (2021-04-01)

Maternal and Fetal Outcome in Intrahepatic Cholestasis of Pregnancy in a Multicultural Society Conducted at a Tertiary Care Hospital in Dubai
by: Nighat Aftab, et al.
Published: (2021-03-01)

Alpha-1 Antitrypsin Z Variant (AAT PI*Z) as a Risk Factor for Intrahepatic Cholestasis of Pregnancy
by: Przemyslaw Kosinski, et al.
Published: (2021-09-01)

Obstetric cholestasis: A case report on rapid bile acid elevation
by: Jennifer J. Yang, et al.
Published: (2023-06-01)

Hepatoprotective agents in the management of intrahepatic cholestasis of pregnancy: current knowledge and prospects
by: Dan Shan, et al.
Published: (2023-08-01)

Increased Serum Met-enkephalin Level in Patients with Intrahepatic Cholestasis of Pregnancy
by: Sema Süzen Çaypınar, et al.
Published: (2022-12-01)

Use of ursodeoxycholic acid in patients with hypertransaminasemia
by: Claudio Puoti, et al.
Published: (2014-09-01)

Non-syndromic perspective on a unique progressive familial intrahepatic cholestasis variant: ZFYVE19 mutation
by: Coşkun Fırat Özkeçeci, et al.
Published: (2024-10-01)

Intrahepatic cholestasis in pregnancy
by: Savić Ž., et al.
Published: (2014-01-01)

Application of metabolomics in intrahepatic cholestasis of pregnancy: a systematic review
by: Zhuoqiao Yang, et al.
Published: (2022-09-01)

Is ursodeoxycholic acid detrimental in obstructive cholestasis? A propos of a case of malignant biliary obstruction
by: Fernando Bessone, et al.
Published: (2016-05-01)

Role of aspartate aminotransferase to platelet ratioin prediction of intrahepatic cholestasis of pregnancy
by: Nizamettin Bozbay, et al.
Published: (2024-12-01)

Cholestasis: exploring the triangular relationship of gut microbiota-bile acid-cholestasis and the potential probiotic strategies
by: Leilei Yu, et al.
Published: (2023-12-01)

Abordaje del paciente con colestasis y síndrome ictérico. Posicionamiento científico conjunto AMH, AMG, AMEG
by: R. Contreras-Omaña, et al.
Published: (2022-01-01)

Pathological bile acid concentrations in chronic cholestasis cause adipose mitochondrial defects
by: Weinan Zhou, et al.
Published: (2023-05-01)

Intrahepatic Cholestasis of Pregnancy Refractory to Multiple Medical Therapies and Plasmapheresis
by: Adam John Covach, et al.
Published: (2017-10-01)

Interactive effects of gestational diabetes mellitus and maximum level of total bile acid in maternal serum on adverse pregnancy outcomes in women with intrahepatic cholestasis of pregnancy
by: Tingting Liao, et al.
Published: (2023-05-01)

Differential Diagnosis and Treatment of Cholestasis Syndrome in Newborns
by: T.M. Klymenko
Published: (2013-09-01)

Diagnostic Significance of Serum Total Bile Acid Levels in Suspected Cases of Obstetric Cholestasis
by: Hijab Batool, et al.
Published: (2020-12-01)

Cholestasis alters brain lipid and bile acid composition and compromises motor function in neonatal piglets
by: Nicole Lind Henriksen, et al.
Published: (2022-07-01)

Maternal liver-related symptoms during pregnancy in primary sclerosing cholangitis
by: Jeremy S. Nayagam, et al.
Published: (2024-01-01)

Host‐Microbial Cometabolite Ursodeoxycholic Acid Protects Against Poststroke Cognitive Impairment
by: Xuxuan Gao, et al.
Published: (2025-05-01)

Ursodeoxycholic acid induces sarcopenia associated with decreased protein synthesis and autophagic flux
by: Josué Orozco-Aguilar, et al.
Published: (2023-05-01)

Effects of ursodeoxycholic acid on the gut microbiome and colorectal adenoma development
by: Talima Pearson, et al.
Published: (2019-02-01)

Role of bile acids in atherogenesis: review
by: A. S. Safaryan
Published: (2024-11-01)