A Lysine Residue at the C-Terminus of MHC Class I Ligands Correlates with Low C-Terminal Proteasomal Cleavage Probability

The majority of peptides presented by MHC class I result from proteasomal protein turnover. The specialized immunoproteasome, which is induced during inflammation, plays a major role in antigenic peptide generation. However, other cellular proteases can, either alone or together with the proteasome,...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Adrian Schmalen, Ilona E. Kammerl, Silke Meiners, Elfriede Noessner, Cornelia A. Deeg, Stefanie M. Hauck
Format:	Article
Language:	English
Published:	MDPI AG 2023-08-01
Subjects:	immunopeptidomics proteasome independent non-canonical MHC class I ligands HLA-A*03:01 HLA-A*11:01 HLA-A*30:01
Online Access:	https://www.mdpi.com/2218-273X/13/9/1300