Loss of intraflagellar transport 140 in osteoblasts cripples bone fracture healing

The indispensability of primary cilia in skeletal development has been widely recognized. We have previously shown that intraflagellar transport 140 (IFT140), a protein component of a bidirectional intraflagellar transport system required for ciliary function, controls bone development and dentinoge...

Full description

Bibliographic Details
Published in:	Fundamental Research
Main Authors:	Qiqi Fan, Xuekui Wang, Mengqi Zhou, Yubei Chen, Dike Tao, Songxi Rong, Shuang Zhou, Hui Xue, Yao Sun
Format:	Article
Language:	English
Published:	KeAi Communications Co. Ltd. 2025-07-01
Subjects:	Primary Cilia Intraflagellar Transport 140 Bone fracture Osteoblasts Bone Mesenchymal Stem Cells
Online Access:	http://www.sciencedirect.com/science/article/pii/S2667325822003715

Similar Items

Mechanisms of Regulation in Intraflagellar Transport
by: Wouter Mul, et al.
Published: (2022-09-01)

The role of retrograde intraflagellar transport genes in aminoglycoside-induced hair cell death
by: Tamara M. Stawicki, et al.
Published: (2019-01-01)

Loss of Kat2b impairs intraflagellar transport and the Hedgehog signaling pathway in primary cilia
by: Jae Hee Jun, et al.
Published: (2025-01-01)

Integrative modeling reveals the molecular architecture of the intraflagellar transport A (IFT-A) complex
by: Caitlyn L McCafferty, et al.
Published: (2022-11-01)

Immersed-Prism TIRF Microscopy for Visualizing Intraflagellar Transport in Live Cells
by: Maya Chauhan, et al.
Published: (2025-10-01)

Testing the ion-current model for flagellar length sensing and IFT regulation
by: Hiroaki Ishikawa, et al.
Published: (2023-01-01)

Occlusal hypofunction affects the gene expression of osteoblast and primary cilia in the alveolar bone: An experimental study
by: HU Lingwei, et al.
Published: (2023-08-01)

Haploinsufficiency of intraflagellar transport protein 172 causes autism-like behavioral phenotypes in mice through BDNF
by: Nanxi Zheng, et al.
Published: (2025-07-01)

Bone development and its relation to fracture repair. The role of mesenchymal osteoblasts and surface osteoblasts
by: F Shapiro
Published: (2008-04-01)

The role of cilia in the development, survival, and regeneration of hair cells
by: Hope Boldizar, et al.
Published: (2024-09-01)

Intraflagellar transport proteins are involved in thrombocyte filopodia formation and secretion
by: Uvaraj Radhakrishnan, et al.
Published: (2018-11-01)

Structural insights into the architecture and assembly of eukaryotic flagella
by: Narcis-Adrian Petriman, et al.
Published: (2020-09-01)

Investigating the Osteoregenerative Properties of <i>Juglans regia</i> L. Extract on Mesenchymal Stem Cells and Osteoblasts Through Evaluation of Bone Markers: A Pilot Study
by: Alina Hanga-Fărcaș, et al.
Published: (2025-07-01)

The roles of intraflagellar transport (IFT) protein 25 in mammalian signaling transduction and flagellogenesis
by: Yong-Hong Man, et al.
Published: (2022-01-01)

Dynein-2–driven intraciliary retrograde trafficking indirectly requires multiple interactions of IFT54 in the IFT-B complex with the dynein-2 complex
by: Shunya Hiyamizu, et al.
Published: (2023-07-01)

Osteoblast-Osteoclast Communication and Bone Homeostasis
by: Jung-Min Kim, et al.
Published: (2020-09-01)

Positional Cloning of cobblestone, a Mouse Mutant Showing Major Defects in Brain Development, Identifies Ift88 as a Candidate Gene
by: Marc A. Willaredt, et al.
Published: (2010-03-01)

Ciliary length regulation by intraflagellar transport in zebrafish
by: Yi Sun, et al.
Published: (2024-12-01)

Characterization of Primary Cilia in Osteoblasts Isolated From Patients With ADPKD and CKD
by: Renata C Pereira, et al.
Published: (2021-04-01)

Dysregulation of Glypicans and Notum in Osteoarthritis: Plasma Levels, Bone Marrow Mesenchymal Stromal Cells and Osteoblasts
by: Irene González-Guede, et al.
Published: (2024-05-01)

HIV Modulates Osteoblast Differentiation via Upregulation of RANKL and Vitronectin
by: Rosa Nicole Freiberger, et al.
Published: (2024-09-01)

The retrograde IFT dynein is required for normal function of diverse mechanosensory cilia in Drosophila
by: Yashoda Sharma, et al.
Published: (2023-09-01)

Primary cilia-associated protein IFT172 in ciliopathies
by: Nan-Xi Zheng, et al.
Published: (2023-01-01)

A WDR35-dependent coat protein complex transports ciliary membrane cargo vesicles to cilia
by: Tooba Quidwai, et al.
Published: (2021-11-01)

Osteogenic differentiation of mesenchymal stem cells is regulated by osteocyte and osteoblast cells in a simplified bone niche
by: LM McNamara, et al.
Published: (2012-01-01)

β-Catenin: A Key Molecule in Osteoblast Differentiation
by: Edyta Wróbel, et al.
Published: (2025-07-01)

IL-1β Inhibits Human Osteoblast Migration
by: Nina-Emily Hengartner, et al.
Published: (2013-03-01)

Nanoscale perfluorocarbon expediates bone fracture healing through selectively activating osteoblastic differentiation and functions
by: Shunhao Wang, et al.
Published: (2020-06-01)

Effects of Laser Application on Alveolar Bone Mesenchymal Stem Cells and Osteoblasts: An In Vitro Study
by: Luminița Lazăr, et al.
Published: (2022-09-01)

140 anos da Casa de Camões
by: Joaquim Costa Pereira Pinto
Published: (1977-06-01)

The osteoblast in regulation of tumor cell dormancy and bone metastasis
by: Jennifer Zarrer, et al.
Published: (2024-04-01)

Woven bone overview: structural classification based on its integral role in developmental, repair and pathological bone formation throughout vertebrate groups
by: F Shapiro, et al.
Published: (2019-09-01)

MicroRNA‐19a‐3p Decreases with Age in Mice and Humans and Inhibits Osteoblast Senescence
by: Japneet Kaur, et al.
Published: (2023-06-01)

Influence of Periodontal Ligament Stem Cell-Derived Conditioned Medium on Osteoblasts
by: Solen Novello, et al.
Published: (2022-03-01)

Effect of lncRNA RMRP on proliferation, apoptosis, osteoblast differentiation and mineralization of bone marrow mesenchymal stem cells
by: Jingyuan Guo, et al.
Published: (2025-06-01)

DP2, a Carbohydrate Derivative, Enhances In Vitro Osteoblast Mineralisation
by: Nissrine Ballout, et al.
Published: (2023-10-01)

Mice with Targeted Knockout of Tetraspanin 3 Exhibit Reduced Trabecular Bone Mass Caused by Decreased Osteoblast Functions
by: Weirong Xing, et al.
Published: (2022-03-01)

Hypergravity as a Possible Way of Bone Tissue Engineering in Osteoblastic Differentiation from Mesenchymal Stem Cells: A Systematic Review
by: Wisnu Sudrajad, et al.
Published: (2024-10-01)

The Role of Formononetin in Osteoblast Function and Mineralization Potential with Deproteinized Bovine Bone Material
by: Ebru Haciosmanoglu Aldogan, et al.
Published: (2024-12-01)

Cadmium-Induced Bone Toxicity: Deciphering the Osteoclast–Osteoblast Crosstalk
by: Shuangjiang He, et al.
Published: (2025-08-01)