Integrative multidimensional analysis of age-associated synthetic lethal genes and development of a prognostic model in breast cancer

BackgroundBreast cancer (BRCA) is the most common malignancy and leading cause of mortality among women, with rising incidence in younger patients. Although treatments have advanced, outcomes for advanced BRCA remain poor. Synthetic lethality (SL) offers promise in precision oncology, but resistance...

Full description

Bibliographic Details
Published in:	Frontiers in Immunology
Main Authors:	Qinqing Wu, Dongxu Ma, Heng Cao, Xiang Wang, Wenjuan Zhang, Wenbing Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-10-01
Subjects:	breast cancer synthetic lethality age machine learning Mendelian randomization SLC7A5
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1690301/full

Similar Items

Cancer‐associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7
by: Joseph S. Baxter, et al.
Published: (2024-02-01)

Potential synthetic lethality for breast cancer: A selective sirtuin 2 inhibitor combined with a multiple kinase inhibitor sorafenib
by: Hua-Li Wang, et al.
Published: (2022-03-01)

Advances in synthetic lethality modalities for glioblastoma multiforme
by: Richard Seidu A.
Published: (2024-06-01)

Synthetic lethal interactions of DEAD/H-box helicases as targets for cancer therapy
by: Ananna Bhadra Arna, et al.
Published: (2023-01-01)

Paralog-based synthetic lethality: rationales and applications
by: Yucui Xin, et al.
Published: (2023-06-01)

Synthetic Lethality in Lung Cancer—From the Perspective of Cancer Genomics
by: Iwao Shimomura, et al.
Published: (2019-03-01)

SLC7A11 protects luminal A breast cancer cells against ferroptosis induced by CDK4/6 inhibitors
by: Yingshu Cui, et al.
Published: (2024-10-01)

CHEK1 is a synthetic lethal interactor of FBXO7 in colonic epithelial cells
by: Tooba Razi, et al.
Published: (2025-09-01)

MYC and the unfolded protein response in cancer: synthetic lethal partners in crime?
by: Tingting Zhang, et al.
Published: (2020-04-01)

Application and research progress of synthetic lethality in the development of anticancer therapeutic drugs
by: Xiaoliang Gong, et al.
Published: (2024-11-01)

Synthetic lethality and the minimal genome size problem
by: Sara Rahiminejad, et al.
Published: (2024-07-01)

Synthetic lethal approaches to target cancers with loss of PTEN function
by: Ayse Ertay, et al.
Published: (2023-11-01)

A compendium of synthetic lethal gene pairs defined by extensive combinatorial pan-cancer CRISPR screening
by: Victoria Harle, et al.
Published: (2025-09-01)

The biological essence of synthetic lethality: Bringing new opportunities for cancer therapy
by: Meiyi Ge, et al.
Published: (2024-03-01)

Treating ARID1A mutated cancers by harnessing synthetic lethality and DNA damage response
by: Jayaprakash Mandal, et al.
Published: (2022-09-01)

Synthetic lethality in cancer: a protocol for scoping review of gene interactions from synthetic lethal screens and functional studies
by: Raashi Chauhan, et al.
Published: (2025-04-01)

MPASL: multi-perspective learning knowledge graph attention network for synthetic lethality prediction in human cancer
by: Ge Zhang, et al.
Published: (2024-05-01)

LRPPRC promotes glycolysis by stabilising LDHA mRNA and its knockdown plus glutamine inhibitor induces synthetic lethality via m6A modification in triple‐negative breast cancer
by: Yuanhang Yu, et al.
Published: (2024-02-01)

An interpretable artificial intelligence framework for designing synthetic lethality-based anti-cancer combination therapies
by: Jing Wang, et al.
Published: (2024-11-01)

Magnetic-driven hydrogel microrobots for promoting osteosarcoma chemo-therapy with synthetic lethality strategy
by: Yining Tao, et al.
Published: (2024-04-01)

Exploiting Synthetic Lethality of PRMT5 for Precision Treatment of MTAP-Deficient Glioblastoma
by: Trang T. T. Nguyen, et al.
Published: (2025-06-01)

Synthetic Lethality between Cohesin and WNT Signaling Pathways in Diverse Cancer Contexts
by: Maria Michela Pallotta, et al.
Published: (2024-03-01)

Synthetic lethality and synergetic effect: the effective strategies for therapy of IDH-mutated cancers
by: Kun Yao, et al.
Published: (2021-08-01)

In Situ Formation of Fibronectin‐Enriched Protein Corona on Epigenetic Nanocarrier for Enhanced Synthetic Lethal Therapy
by: Zhangyi Luo, et al.
Published: (2024-05-01)

Research progress for the development of anti-tumor drugs based on synthetic lethality
by: Chen Pei, et al.
Published: (2022-03-01)

The potential and challenges of targeting MTAP-negative cancers beyond synthetic lethality
by: Chandler Bray, et al.
Published: (2023-09-01)

Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts
by: Petra van der Lelij, et al.
Published: (2017-07-01)

Using graph-based model to identify cell specific synthetic lethal effects
by: Mengchen Pu, et al.
Published: (2023-01-01)

The synthetic lethality of targeting cell cycle checkpoints and PARPs in cancer treatment
by: Shuangying Li, et al.
Published: (2022-10-01)

Therapeutic Role of Synthetic Lethality in ARID1A-Deficient Malignancies
by: Kyaw Z. Hein, et al.
Published: (2024-02-01)

Advances in synthetic lethality for cancer therapy: cellular mechanism and clinical translation
by: Win Topatana, et al.
Published: (2020-09-01)

Genome‐scale gene/reaction essentiality and synthetic lethality analysis
by: Patrick F Suthers, et al.
Published: (2009-08-01)

Integrative omics analysis reveals relationships of genes with synthetic lethal interactions through a pan-cancer analysis
by: Li Guo, et al.
Published: (2020-01-01)

Integrated multi-omics analysis reveals the functional and prognostic significance of lactylation-related gene PRDX1 in breast cancer
by: Qinqing Wu, et al.
Published: (2025-04-01)

Metabolic synthetic lethality by targeting NOP56 and mTOR in KRAS-mutant lung cancer
by: Zhang Yang, et al.
Published: (2022-01-01)

Mechanism of RBBP8‐mediated homologous recombination repair in gastric cancer synthetic lethal
by: Yang Yu, et al.
Published: (2023-09-01)

Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma
by: Benjamin Lin, et al.
Published: (2025-06-01)

Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in KrasG12D-driven tumors
by: Patricia Santofimia-Castaño, et al.
Published: (2024-02-01)

Evidence of a synthetic lethality interaction between SETDB1 histone methyltransferase and CHD4 chromatin remodeling protein in a triple negative breast cancer cell line
by: M.S. Moraes-Almeida, et al.
Published: (2023-11-01)

Synthetic lethality between VPS4A and VPS4B triggers an inflammatory response in colorectal cancer
by: Ewelina Szymańska, et al.
Published: (2020-01-01)