Aberrations in peripheral B lymphocytes and B lymphocyte subsets levels in Parkinson disease: a systematic review

• Published in: Frontiers in Immunology
• Main Authors: Hongxia Ma, Ziyuan Wang, Miao Yu, Yibo Zhai, Junqiang Yan
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2025-03-01
• Subjects: B lymphocyte; B lymphocyte subsets; Parkinson’s disease; Pathogenesis; Immunity; Inflammation
• Online Access: https://www.frontiersin.org/articles/10.3389/fimmu.2025.1526095/full

ObjectiveThe association of B lymphocytes and B lymphocyte subsets and Parkinson’s disease (PD) is increasingly acknowledged. However, there is inconsistence in the alterations of B lymphocytes or B lymphocyte subsets in peripheral blood of PD patients. To comprehensively understand its changes in PD patients,it is necessary to conduct a systematic review on this subject.MethodsPubMed, Cochrane Library, and MEDLINE databases were searched until 3rd February 2024.ResultsWe included 20 studies (n=2658) to conduct this systematic review. We conducted a qualitative analysis to assess the alterations of B lymphocytes and B lymphocyte subsets in the peripheral blood of individuals with PD. And studies reviewed demonstrated a significant decrease in the number of B cells, as well as immune dysregulation in the B lymphocyte subsets of these patients’ peripheral blood.ConclusionStudies reviewed demonstrated that PD is linked to abnormalities in B lymphocytes and/or B lymphocytes subsets in peripheral blood. This study provides a novel perspective into the pathogenesis of PD, and future investigations into the B lymphocytes and/or B lymphocyte subsets as biomarkers and therapeutic targets for PD is warranted.