Gut microbiota disparities between active Crohn's disease and healthy controls: A global systematic review

Purpose: Crohn's disease (CD) is challenging to manage. It has been suggested that modifying the gut microbiota could be a treatment strategy. We performed this systematic review to compare the gut microbiota between active CD and healthy controls. Results: The family Enterobacteriaceae and gen...

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Bibliographic Details
Published in:Clinical Epidemiology and Global Health
Main Authors: Rupa Tharu, Geetika Malik Ahlawat, Savitesh Kushwaha, Poonam Khanna
Format: Article
Language:English
Published: Elsevier 2024-01-01
Subjects:
Crohn's disease
IBD
Systematic review
Gut microbiota
Online Access:http://www.sciencedirect.com/science/article/pii/S2213398423002841
Description
Summary:Purpose: Crohn's disease (CD) is challenging to manage. It has been suggested that modifying the gut microbiota could be a treatment strategy. We performed this systematic review to compare the gut microbiota between active CD and healthy controls. Results: The family Enterobacteriaceae and genus Bacteroides were increased in active CD compared to controls in 13 and 8 studies, respectively. The family Oscillospiraceae and genus Faecalibacterium decreased in active CD vs controls in 12 and 10 studies, respectively. Conclusion: Specific bacteria were associated with the microbiomes of active CD patients versus controls, offering insights into potential microbial targets for CD treatments.
ISSN:2213-3984

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