Management of disseminated intravascular coagulation: current insights on antithrombin and thrombomodulin treatments

Mineji Hayakawa Emergency and Critical Care Center, Hokkaido University Hospital, Sapporo, Japan Abstract: Sepsis and septic shock are frequently complicated by disseminated intravascular coagulation (DIC), which decreases the survival rate of patients with sepsis. In the past, large international r...

Full description

Bibliographic Details
Published in:	Open Access Emergency Medicine
Main Author:	Hayakawa M
Format:	Article
Language:	English
Published:	Dove Medical Press 2017-12-01
Subjects:	Antithrombin Disseminated intravascular coagulation Sepsis Thrombomodulin
Online Access:	https://www.dovepress.com/management-of-disseminated-intravascular-coagulation-current-insights--peer-reviewed-article-OAEM

Similar Items

Use of Antithrombin and Thrombomodulin in the Management of Disseminated Intravascular Coagulation in Patients with Acute Cholangitis
Published: (2013-05-01)

Effects of combination therapy of antithrombin and thrombomodulin for sepsis-associated disseminated intravascular coagulation: a systematic review and meta-analysis
by: Takaaki Totoki, et al.
Published: (2024-01-01)

Combination of antithrombin and soluble thrombomodulin for early prediction of sepsis-Induced disseminated intravascular coagulation
by: Huan Zeng, et al.
Published: (2025-10-01)

Sepsis-Associated DIC with Decreased Levels of Antithrombin and Fibrinogen is the Target for Combination Therapy with Thrombomodulin Alfa and Antithrombin
by: Hideo Wada, et al.
Published: (2023-01-01)

The pathophysiology, diagnosis, and management of sepsis-associated disseminated intravascular coagulation
by: Toshiaki Iba, et al.
Published: (2023-05-01)

Thrombomodulin: A key regulator of intravascular blood coagulation, fibrinolysis, and inflammation, and a treatment for disseminated intravascular coagulation
by: Koji SUZUKI
Published: (2024-12-01)

Successful treatment for disseminated intravascular coagulation (DIC) corresponding to phenotype changes in a heat stroke patient
by: Hironori Matsumoto, et al.
Published: (2019-01-01)

A retrospective study on safety and efficacy of recombinant human soluble thrombomodulin to acute aortic dissection with disseminated intravascular coagulation
by: Tsukasa Ikeda, et al.
Published: (2024-09-01)

Clinical Impact of Recombinant Soluble Thrombomodulin for Disseminated Intravascular Coagulation Associated with Severe Acute Cholangitis
by: Atsushi Okuda, et al.
Published: (2018-07-01)

Effects of thrombomodulin alfa on hemostatic parameters in disseminated intravascular coagulation: Post hoc analysis of a phase 3 randomized controlled trial
by: Takashi Ito, et al.
Published: (2020-10-01)

The antithrombin activity recovery after substitution therapy is associated with improved 28-day mortality in patients with sepsis-associated disseminated intravascular coagulation
by: Toshiaki Iba, et al.
Published: (2023-11-01)

Factors influencing antithrombin activity following supplementation in sepsis-associated disseminated intravascular coagulation
by: Tomoki Tanigawa, et al.
Published: (2025-10-01)

Circulating activated protein C levels are not increased in septic patients treated with recombinant human soluble thrombomodulin
by: Takuro Arishima, et al.
Published: (2018-09-01)

Overt disseminated intravascular coagulation and antithrombin III predict bleeding and in-hospital mortality in patients undergoing extracorporeal membrane oxygenation
by: Tae Wan Kim, et al.
Published: (2024-04-01)

Determining prognostic indicator for anticoagulant therapy in sepsis-induced disseminated intravascular coagulation
by: Toshiaki Iba, et al.
Published: (2024-06-01)

Disseminated intravascular coagulation: A review of the topic
by: Alejandro Hernández-Martínez, et al.
Published: (2018-08-01)

Sepsis, leukocytes, cytokines and disseminated intravascular coagulation
by: Ramazan Çöl, et al.

Efficacy of antithrombin administration for patients with sepsis: A systematic review, meta‐analysis, and meta‐regression
by: Takumi Tsuchida, et al.
Published: (2024-01-01)

Anticoagulant therapies against sepsis‐induced disseminated intravascular coagulation
by: Yutaka Umemura, et al.
Published: (2023-01-01)

Attempt for a Recombinant Thrombomodulin Alpha Treatment in a Rat Disseminated Intravascular Coagulation Model Using Yamakagashi (<i>Rhabdophis tigrinus</i>) Venom
by: Akihiko Yamamoto, et al.
Published: (2022-05-01)

Impact of Different Treatments for Disseminated Intravascular Coagulation on Patients with or without Biliary Drainage for Severe Biliary Tract Infection
by: Kobayashi M, et al.
Published: (2023-11-01)

Mechanism and treatment progress of disseminated intravascular coagulation in sepsis
by: ZHANG Jun, FENG Jianhong, DU Xianrong
Published: (2024-11-01)

Pathophysiology of Disseminated Intravascular Coagulation in Sepsis: A Clinically Focused Overview
by: Ahsanullah Unar, et al.
Published: (2023-08-01)

Thrombomodulin as a Physiological Modulator of Intravascular Injury
by: Kanako Watanabe-Kusunoki, et al.
Published: (2020-09-01)

Differential effect of lactate in predicting mortality in septic patients with or without disseminated intravascular coagulation: a multicenter, retrospective, observational study
by: Daisuke Hasegawa, et al.
Published: (2019-06-01)

Disseminated Intravascular Coagulation in a Case of Gastric Adenocarcinoma
by: Betül Çavuşoğlu, et al.
Published: (2015-09-01)

Diagnosis of sepsis‐induced disseminated intravascular coagulation and coagulopathy
by: Toshiaki Iba, et al.
Published: (2019-07-01)

Can disseminated intravascular coagulation scores predict mortality in COVID-19 patients?
by: Nimra Anwar, MBBS, et al.
Published: (2021-08-01)

Real‐world evidence on disseminated intravascular coagulation from Japan
by: Ryo Hisamune, et al.
Published: (2023-01-01)

Time series differences in coagulopathy in mechanically ventilated COVID-19 and bacterial pneumonia patients: a nationwide observational study in Japan
by: Ryo Hisamune, et al.
Published: (2025-06-01)

Aneurysm-related disseminated intravascular coagulation successfully treated by endovascular repair
by: Miguel Lemos Gomes, et al.
Published: (2019-12-01)

Faktor Risiko Mortalitas Anak dengan Sepsis dan Disseminated Intravascular Coagulation: Peran Penanda Inflamasi dan Koagulasi di Rumah Sakit Zainoel Abidin Banda Aceh
by: Alivia Rizky Nuriyanto, et al.
Published: (2025-06-01)

Sepsis‐induced disseminated intravascular coagulation: an international estrangement of disease concept
by: Noritaka Ushio, et al.
Published: (2023-01-01)

Impact of Lactate on Disseminated Intravascular Coagulation in Patients with Severe Trauma
by: Chao Nan, et al.
Published: (2024-08-01)

Surgery-related disseminated intravascular coagulation predicts postoperative complications
by: Yuki Imaoka, et al.
Published: (2023-04-01)

The transition of the criteria for disseminated intravascular coagulation and the targeted patients in randomized controlled trials over the decades: a scoping review
by: Tadashi Matsuoka, et al.
Published: (2024-12-01)

TRACHEOSTOMY IN THE PATIENT WITH DISSEMINATED INTRAVASCULAR COAGULATION
by: A. V. Schyogolev, et al.
Published: (2017-11-01)

Images in Emergency Medicine: Purpura Fulminans: A Cutaneous Marker of Disseminated Intravascular Coagulation
by: Ghosh, Sudip Kumar, et al.
Published: (2009-02-01)

A machine learning model for early and accurate prediction of overt disseminated intravascular coagulation before its progression to an overt stage
by: Yutaka Umemura, et al.
Published: (2024-07-01)

Disseminated intravascular coagulation
by: Satoshi Gando, et al.
Published: (2025-06-01)