The Role of Extracellular Vesicles in the Pathogenesis and Treatment of Rheumatoid Arthritis and Osteoarthritis
Cells can communicate with each other through extracellular vesicles (EVs), which are membrane-bound structures that transport proteins, lipids and nucleic acids. These structures have been found to mediate cellular differentiation and proliferation apoptosis, as well as inflammatory responses and s...
| Published in: | Cells |
|---|---|
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-11-01
|
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/12/23/2716 |
| _version_ | 1850124424299151360 |
|---|---|
| author | Estera Bakinowska Kajetan Kiełbowski Andrzej Pawlik |
| author_facet | Estera Bakinowska Kajetan Kiełbowski Andrzej Pawlik |
| author_sort | Estera Bakinowska |
| collection | DOAJ |
| container_title | Cells |
| description | Cells can communicate with each other through extracellular vesicles (EVs), which are membrane-bound structures that transport proteins, lipids and nucleic acids. These structures have been found to mediate cellular differentiation and proliferation apoptosis, as well as inflammatory responses and senescence, among others. The cargo of these vesicles may include immunomodulatory molecules, which can then contribute to the pathogenesis of various diseases. By contrast, EVs secreted by mesenchymal stem cells (MSCs) have shown important immunosuppressive and regenerative properties. Moreover, EVs can be modified and used as drug carriers to precisely deliver therapeutic agents. In this review, we aim to summarize the current evidence on the roles of EVs in the progression and treatment of rheumatoid arthritis (RA) and osteoarthritis (OA), which are important and prevalent joint diseases with a significant global burden. |
| format | Article |
| id | doaj-art-e388efb540aa4bcf83c5ccfc3de4f526 |
| institution | Directory of Open Access Journals |
| issn | 2073-4409 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-e388efb540aa4bcf83c5ccfc3de4f5262025-08-19T23:55:06ZengMDPI AGCells2073-44092023-11-011223271610.3390/cells12232716The Role of Extracellular Vesicles in the Pathogenesis and Treatment of Rheumatoid Arthritis and OsteoarthritisEstera Bakinowska0Kajetan Kiełbowski1Andrzej Pawlik2Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Physiology, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Physiology, Pomeranian Medical University, 70-111 Szczecin, PolandCells can communicate with each other through extracellular vesicles (EVs), which are membrane-bound structures that transport proteins, lipids and nucleic acids. These structures have been found to mediate cellular differentiation and proliferation apoptosis, as well as inflammatory responses and senescence, among others. The cargo of these vesicles may include immunomodulatory molecules, which can then contribute to the pathogenesis of various diseases. By contrast, EVs secreted by mesenchymal stem cells (MSCs) have shown important immunosuppressive and regenerative properties. Moreover, EVs can be modified and used as drug carriers to precisely deliver therapeutic agents. In this review, we aim to summarize the current evidence on the roles of EVs in the progression and treatment of rheumatoid arthritis (RA) and osteoarthritis (OA), which are important and prevalent joint diseases with a significant global burden.https://www.mdpi.com/2073-4409/12/23/2716extracellular vesiclesexosomesrheumatoid arthritisosteoarthritismesenchymal stem cells |
| spellingShingle | Estera Bakinowska Kajetan Kiełbowski Andrzej Pawlik The Role of Extracellular Vesicles in the Pathogenesis and Treatment of Rheumatoid Arthritis and Osteoarthritis extracellular vesicles exosomes rheumatoid arthritis osteoarthritis mesenchymal stem cells |
| title | The Role of Extracellular Vesicles in the Pathogenesis and Treatment of Rheumatoid Arthritis and Osteoarthritis |
| title_full | The Role of Extracellular Vesicles in the Pathogenesis and Treatment of Rheumatoid Arthritis and Osteoarthritis |
| title_fullStr | The Role of Extracellular Vesicles in the Pathogenesis and Treatment of Rheumatoid Arthritis and Osteoarthritis |
| title_full_unstemmed | The Role of Extracellular Vesicles in the Pathogenesis and Treatment of Rheumatoid Arthritis and Osteoarthritis |
| title_short | The Role of Extracellular Vesicles in the Pathogenesis and Treatment of Rheumatoid Arthritis and Osteoarthritis |
| title_sort | role of extracellular vesicles in the pathogenesis and treatment of rheumatoid arthritis and osteoarthritis |
| topic | extracellular vesicles exosomes rheumatoid arthritis osteoarthritis mesenchymal stem cells |
| url | https://www.mdpi.com/2073-4409/12/23/2716 |
| work_keys_str_mv | AT esterabakinowska theroleofextracellularvesiclesinthepathogenesisandtreatmentofrheumatoidarthritisandosteoarthritis AT kajetankiełbowski theroleofextracellularvesiclesinthepathogenesisandtreatmentofrheumatoidarthritisandosteoarthritis AT andrzejpawlik theroleofextracellularvesiclesinthepathogenesisandtreatmentofrheumatoidarthritisandosteoarthritis AT esterabakinowska roleofextracellularvesiclesinthepathogenesisandtreatmentofrheumatoidarthritisandosteoarthritis AT kajetankiełbowski roleofextracellularvesiclesinthepathogenesisandtreatmentofrheumatoidarthritisandosteoarthritis AT andrzejpawlik roleofextracellularvesiclesinthepathogenesisandtreatmentofrheumatoidarthritisandosteoarthritis |