A Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN

The cellular response to replication stress requires the DNA-damage-responsive kinase ATM and its cofactor ATMIN; however, the roles of this signaling pathway following replication stress are unclear. To identify the functions of ATM and ATMIN in response to replication stress, we utilized both tran...

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Bibliographic Details
Published in:Cell Reports
Main Authors: Abdelghani Mazouzi, Alexey Stukalov, André C. Müller, Doris Chen, Marc Wiedner, Jana Prochazkova, Shih-Chieh Chiang, Michael Schuster, Florian P. Breitwieser, Andreas Pichlmair, Sherif F. El-Khamisy, Christoph Bock, Robert Kralovics, Jacques Colinge, Keiryn L. Bennett, Joanna I. Loizou
Format: Article
Language:English
Published: Elsevier 2016-04-01
Subjects:
replication stress
phosphoproteomics
gene regulation
ATM
ATMIN
γH2AX
CRMP2
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716303667

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