NNKTT120, an anti-iNKT cell monoclonal antibody, produces rapid and sustained iNKT cell depletion in adults with sickle cell disease.

Invariant NKT (iNKT) cells can be activated to stimulate a broad inflammatory response. In murine models of sickle cell disease (SCD), interruption of iNKT cell activity prevents tissue injury from vaso-occlusion. NKTT120 is an anti-iNKT cell monoclonal antibody that has the potential to rapidly and...

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出版年:	PLoS ONE
主要な著者:	Joshua J Field, Elaine Majerus, Kenneth I Ataga, Elliot P Vichinsky, Robert Schaub, Robert Mashal, David G Nathan
フォーマット:	論文
言語:	英語
出版事項:	Public Library of Science (PLoS) 2017-01-01
オンライン･アクセス:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0171067&type=printable