Deplete and repeat: microglial CSF1R inhibition and traumatic brain injury

Traumatic brain injury (TBI) is a public health burden affecting millions of people. Sustained neuroinflammation after TBI is often associated with poor outcome. As a result, increased attention has been placed on the role of immune cells in post-injury recovery. Microglia are highly dynamic after T...

Full description

Bibliographic Details
Published in:	Frontiers in Cellular Neuroscience
Main Authors:	Rebecca Boland, Olga N. Kokiko-Cochran
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-02-01
Subjects:	microglia traumatic brain injury CSF1R neuroinflammation PLX5622
Online Access:	https://www.frontiersin.org/articles/10.3389/fncel.2024.1352790/full

Similar Items

Proliferation and Differentiation in the Adult Subventricular Zone Are Not Affected by CSF1R Inhibition
by: Jackson Kyle, et al.
Published: (2019-04-01)

Significant Sex Differences in the Efficacy of the CSF1R Inhibitor-PLX5622 on Rat Brain Microglia Elimination
by: Aviv Sharon, et al.
Published: (2022-05-01)

Microglia depletion fails to abrogate inflammation-induced sickness in mice and rats
by: Elisabeth G. Vichaya, et al.
Published: (2020-05-01)

Microglia preserve visual function in the aging retina by supporting retinal pigment epithelial health
by: Margarete M. Karg, et al.
Published: (2023-10-01)

Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis
by: Nils Mein, et al.
Published: (2023-12-01)

RNA-seq and network analysis reveal unique glial gene expression signatures during prion infection
by: James A. Carroll, et al.
Published: (2020-05-01)

Distinguished Functions of Microglia in the Two Stages of Oxygen-Induced Retinopathy: A Novel Target in the Treatment of Ischemic Retinopathy
by: Ziyi Zhou, et al.
Published: (2022-10-01)

Microglia Are Necessary to Regulate Sleep after an Immune Challenge
by: Rachel K. Rowe, et al.
Published: (2022-08-01)

CSF1R antagonism limits local restimulation of antiviral CD8+ T cells during viral encephalitis
by: Kristen E. Funk, et al.
Published: (2019-01-01)

The role of P2Y12 in the kinetics of microglial self-renewal and maturation in the adult visual cortex in vivo
by: Monique S Mendes, et al.
Published: (2021-07-01)

Microglia shield the murine brain from damage mediated by the cytokines IL-6 and IFN-α
by: Phillip K. West, et al.
Published: (2022-10-01)

Distinguishing the effects of systemic CSF1R inhibition by PLX3397 on microglia and peripheral immune cells
by: Akhabue K. Okojie, et al.
Published: (2023-10-01)

Human-induced pluripotent stem cell-derived microglia integrate into mouse retina and recapitulate features of endogenous microglia
by: Wenxin Ma, et al.
Published: (2024-11-01)

Growing microglia in the lab
by: Jonathan M Levenson, et al.
Published: (2024-10-01)

Microglial depletion exacerbates axonal damage and motor dysfunction in mice with cuprizone-induced demyelination
by: Shinji Yamamoto, et al.
Published: (2023-11-01)

Microglia Depletion from Primary Glial Cultures Enables to Accurately Address the Immune Response of Astrocytes
by: Mariana Van Zeller, et al.
Published: (2022-05-01)

Context is key: glucocorticoid receptor and corticosteroid therapeutics in outcomes after traumatic brain injury
by: Morgan A. Taylor, et al.
Published: (2024-03-01)

Microglia depletion/repopulation does not affect light-induced retinal degeneration in mice
by: Nils Laudenberg, et al.
Published: (2024-01-01)

Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition
by: Anna C. Stoll, et al.
Published: (2024-04-01)

Colony-Stimulating Factor-1 Receptor Inhibition Transiently Attenuated the Peripheral Immune Response to Experimental Traumatic Brain Injury
by: Katherine R. Giordano, et al.
Published: (2023-04-01)

Microglial depletion rescues spatial memory impairment caused by LPS administration in adult mice
by: Tao Zong, et al.
Published: (2024-11-01)

What microglia depletion approaches tell us about the role of microglia on synaptic function and behavior
by: Bernadette Basilico, et al.
Published: (2022-11-01)

Microglial Activation in Traumatic Brain Injury
by: Cornelius K. Donat, et al.
Published: (2017-06-01)

Microglial responses to CSF1 overexpression do not promote the expansion of other glial lineages
by: Ishani De, et al.
Published: (2021-07-01)

Dual-targeting CSF1R signaling attenuates neurotoxic myeloid activation and preserves photoreceptors in retinitis pigmentosa
by: Jiangmei Wu, et al.
Published: (2025-07-01)

Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Interacts With Colony-Stimulating Factor 1 Receptor (CSF1R) but Is Not Necessary for CSF1/CSF1R-Mediated Microglial Survival
by: Baoying Cheng, et al.
Published: (2021-03-01)

Recent Advances in Basic Research for CSF1R-Microglial Encephalopathy
by: Yan-Li Wang, et al.
Published: (2021-12-01)

Inhibition of Colony Stimulating Factor 1 Receptor Suppresses Neuroinflammation and Neonatal Hypoxic-Ischemic Brain Injury
by: Bohao Zhang, et al.
Published: (2021-02-01)

Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes
by: Laura E Kuil, et al.
Published: (2020-05-01)

Is the Relationship Between Adolescent Social Isolation and Anxiety‐Like Behaviors Altered by Microglia Ablation in Female Long Evans Rats?
by: Matthew A. Blumberg, et al.
Published: (2025-03-01)

Limitations of PLX3397 as a microglial investigational tool: peripheral and off-target effects dictate the response to inflammation
by: Wouter Claeys, et al.
Published: (2023-11-01)

Differential regulation of microglial states by colony stimulating factors
by: E. Richard Stanley, et al.
Published: (2023-10-01)

Phillyrin Prevents Neuroinflammation-Induced Blood–Brain Barrier Damage Following Traumatic Brain Injury via Altering Microglial Polarization
by: Qian Jiang, et al.
Published: (2021-10-01)

Narirutin mitigates neuroinflammation following traumatic brain injury and modulates microglial polarization via the JAK2/STAT3 signaling pathway
by: Hebo Zhang, et al.
Published: (2025-10-01)

Suppression of inner blood-retinal barrier breakdown and pathogenic Müller glia activation in ischemia retinopathy by myeloid cell depletion
by: Lingli Zhou, et al.
Published: (2024-08-01)

Colony-stimulating factor-1 receptor inhibition combined with paclitaxel exerts effective antitumor effects in the treatment of ovarian cancer
by: Meijia Yu, et al.
Published: (2024-05-01)

Microglia-induced neuroinflammation in hippocampal neurogenesis following traumatic brain injury
by: Seyedeh Parisa Navabi, et al.
Published: (2024-08-01)

Sex Dimorphism Influences Cortical Microglial Morphological and Phenotypic Marker Profile after Closed Head Mild Traumatic Brain Injury in Rats
by: Pooja M. Datta Roy, et al.
Published: (2025-01-01)

Protein Expression of the Microglial Marker Tmem119 Decreases in Association With Morphological Changes and Location in a Mouse Model of Traumatic Brain Injury
by: Domenico Mercurio, et al.
Published: (2022-02-01)

CSF1R inhibitor (PLX3397) alleviates experimental periodontitis by reducing macrophage senescence through the PI3K/AKT/FOXO1 signaling pathway
by: Jiabing Kang, et al.
Published: (2025-07-01)