Efficacy of adjunctive periodontal interventions in non-surgical periodontal therapy for Stage III/IV Grade C periodontitis: A systematic review and network meta-analysis

This study evaluates the effectiveness of adjunctive therapies combined with non-surgical periodontal treatment for Stage III/IV Grade C periodontitis, focusing on pocket depth (PD) reduction, clinical attachment level (CAL) gain, and adverse events. A systematic review and network meta-analysis wer...

Full description

Bibliographic Details
Published in:	Japanese Dental Science Review
Main Authors:	Shih-Ying Lin, Hung-Ying Lin, Jui-Sheng Sun, Jenny Zwei-Chieng Chang
Format:	Article
Language:	English
Published:	Elsevier 2025-12-01
Subjects:	Aggressive periodontitis Stage III/IV Grade C Non-surgical periodontal therapy Adjunctive periodontal treatment Meta-analysis
Online Access:	http://www.sciencedirect.com/science/article/pii/S1882761625000134

Similar Items

Progress of diagnosis and treatment decisions in stage Ⅲ/Ⅳ periodontitis
by: CHEN Xu, LI Lu, WANG Xiaoqian, WANG Tianyao, XU Yan
Published: (2025-01-01)

Herbal medicine as adjunct in periodontal therapies- A review of clinical trials in past decade
by: Hossam Abdelatty Eid Abdelmagyd, et al.
Published: (2019-07-01)

Association of supragingival plaque management with subgingival microbiota is moderated by adjunctive antibiotics in stage III-IV periodontitis patients during periodontal therapy
by: Kyana Charlotte Laura Saberi Kakhki, et al.
Published: (2025-12-01)

Cost analysis of treatment for periodontitis stages I–IV based on periodontal status and number of visits: a retrospective study at the Dental Teaching Hospital
by: Aysha Azzahra B., et al.
Published: (2025-10-01)

Orthodontic Management of Different Stages and Grades of Periodontitis According to the 2017 Classification of Periodontal Diseases
by: Nada Tawfig Hashim, et al.
Published: (2025-01-01)

Do Lasers Have an Adjunctive Role in Initial Non-Surgical Periodontal Therapy? A Systematic Review
by: Donald Coluzzi, et al.
Published: (2020-08-01)

Antibiotics in the management of aggressive periodontitis
by: Abinaya Prakasam, et al.
Published: (2012-01-01)

Effects of Local and Systemic Metronidazole as Adjunctive Treatment in Chronic Periodontitis Patients
by: Maryam Mehravani, et al.
Published: (2024-12-01)

Efficacy of metformin as an adjunct in periodontitis: A systematic analysis
by: Muhammad K.H. Uddin, PhD, et al.
Published: (2026-04-01)

The impact of Limosilactobacillus reuteri in combination with non-surgical periodontal therapy on periodontal clinical parameters and salivary and subgingival microbiota composition in individuals with stage III–IV periodontitis: a randomized controlled trial
by: Pengcheng Huo, et al.
Published: (2025-05-01)

Propolis as an Adjunct in Non-Surgical Periodontal Therapy: Current Clinical Perspectives from a Narrative Review
by: Vitolante Pezzella, et al.
Published: (2025-07-01)

Orthodontic considerations and timing selection for patients with stage Ⅳ periodontitis
by: PENG Yan, ZHANG Chi, GAO Li, LI Xiting, ZHAO Chuanjiang
Published: (2025-01-01)

Clinical Assessment of Drug Adjunctive Therapy Effects in Association with Chronic Generalized Periodontitis and Osteoporotic Disease*
by: Ursarescu Irina-Georgeta, et al.
Published: (2015-11-01)

Perawatan maloklusi skeletal kelas I bidental protrusion disertai periodontitis stage IV grade B<p></p>Treatment of class I skeletal malocclusion with bidental protrusion and stage IV grade B periodontitis<p>
by: Bayu Rachma Gullianne, et al.
Published: (2022-03-01)

Anna Karenina and the subgingival microbiome associated with periodontitis
by: Khaled Altabtbaei, et al.
Published: (2021-04-01)

Multifactorial analysis of factors influencing premolar mobility in stage III/IV grade C periodontitis patients ≤ 35 years of age: a cross-sectional study
by: Jia-Ming Li, et al.
Published: (2024-10-01)

Blue Photosensitizer, Red Light, Clear Results: An Integrative Review of the Adjunctive Periodontal Treatment with Methylene Blue in Antimicrobial Photodynamic Therapy
by: Higor Henrique Carvalho Oliveira, et al.
Published: (2025-06-01)

"What is there in a name?": A literature review on chronic and aggressive periodontitis
by: Sameera G Nath, et al.
Published: (2011-01-01)

Agresif periodontitis hastalarında periodontal doku yıkımının dişeti oluğu sıvısı hacmi üzerine etkisi
by: Şadiye Coşkuner
Published: (2016-12-01)

Efficacy of omega 3 fatty acid as an adjunct in the management of chronic periodontitis: A randomized controlled trial
by: Shirish K Kujur, et al.
Published: (2020-01-01)

Periodontal Status and Herpesiviridae, Bacteria, and Fungi in Gingivitis and Periodontitis of Systemically Compromised Pediatric Subjects: A Systematic Review
by: Federica Di Spirito, et al.
Published: (2025-03-01)

Adjunctive Systemic Azithromycin with Nonsurgical Periodontal Treatment: Effects on Clinical Parameters in Smokers with Periodontitis
by: Melike Camgoz, et al.
Published: (2023-01-01)

Microbiota Transplantation as an Adjunct to Standard Periodontal Treatment in Periodontal Disease: A Systematic Review
by: Cherry Erlin Lindo, et al.
Published: (2024-04-01)

Automating bone loss measurement on periapical radiographs for predicting the periodontitis stage and grade
by: Nazila Ameli, et al.
Published: (2024-10-01)

IL29 expression in gingival tissues of chronic periodontitis and aggressive periodontitis patients: An immunohistochemical analysis
by: Zahra Alizadeh Tabari, et al.
Published: (2021-01-01)

Assessment of periodontitis as a predictive sign of occurrence of type-II diabetes mellitus
by: Ayoub Ibrahim Al Kharusi, et al.
Published: (2025-06-01)

REAL TIME PCR IDENTIFICATION FOR TARGET ADJUNCTIVE ANTIBIOTIC THERAPY OF SEVERE CHRONIC PERIODONTITIS. PART II - MICROBIOLOGICAL EFFECTIVENESS.
by: Kamen Kotsilkov, et al.
Published: (2014-10-01)

<i>Salvadora persica</i>: Nature’s Gift for Periodontal Health
by: Mohamed Mekhemar, et al.
Published: (2021-04-01)

Adapting to emergent paradigm shifts: A calibration study among graduating dental students using the new classification of periodontal diseases
by: Mohamed Roshdy Abdelrasoul, et al.
Published: (2024-12-01)

The Adjunctive Role of Probiotics in Periodontal Therapy: A Narrative Review
by: Natalia de Campos Kajimoto, et al.
Published: (2026-04-01)

The Impact of Orthodontic Treatment on Stage III / Grade C Periodontitis: A Systematic Review
by: LEKESSE APILA Chanelle, et al.
Published: (2024-03-01)

Impact of aggressive periodontitis and chronic periodontitis on oral health-related quality of life
by: Alexandre Hugo LLANOS, et al.
Published: (2018-02-01)

Discordance in the 2018 Periodontal Classification: Conceptual Challenges and a Biologically Grounded Framework for Interpretation
by: Nada Tawfig Hashim, et al.
Published: (2026-06-01)

Identification of Dermal Crease Patterns as a Link between Genetics and Periodontitis: Reliability and Credibility
by: B. Bharghavi Patnaik, et al.
Published: (2024-06-01)

20 abnormal metabolites of Stage IV Grade C periodontitis was discovered by CPSI-MS
by: Li-Jun Wang, et al.
Published: (2022-12-01)

The role of non-steroidal anti-inflammatory drugs as adjuncts to periodontal treatment and in periodontal regeneration
by: Jianhan Ren, et al.
Published: (2023-02-01)

Preventing alveolar ridge resorption by rehabilitating with fenestrated and overdenture in aggressive periodontitis
by: Arpana Arora, et al.
Published: (2016-01-01)

Periodontal manifestations as related to the cytokines in the gingival crevicular fluid
by: Nymphea Pandit, et al.
Published: (2021-01-01)

Efficacy of Subgingival Air Polishing in Patients with Aggressive Periodontitis
by: Trtić N., et al.
Published: (2016-11-01)

Effect of Periodontal Debridement plus Systemic Azithromycin in subjects with Stage III Periodontitis: A Randomized Controlled Clinical Trial.
by: Mariely Navarrete, et al.
Published: (2022-10-01)