Oncolytic Vaccinia Virus Armed with GM-CSF and IL-7 Enhances Antitumor Immunity in Pancreatic Cancer
<b>Objectives:</b> Pancreatic cancer remains a therapeutic challenge due to its immunosuppressive microenvironment and treatment resistance. This study aimed to develop a novel recombinant oncolytic vaccinia virus (VVL-GL7) co-expressing granulocyte-macrophage colony-stimulating factor (...
| Published in: | Biomedicines |
|---|---|
| Main Authors: | Wenyi Yan, Yujing Xuan, Ruimin Wang, Ziyan Huan, Yu Guo, Huilin Dun, Lihua Xu, Ruxia Han, Xianlei Sun, Lingling Si, Nicholas Robert Lemoine, Yaohe Wang, Pengju Wang |
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-04-01
|
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/13/4/882 |
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