Progress of Research on Tumor Extracellular Matrix and Discoidin Domain Receptor 1

Tumor extracellular matrix (ECM) is the center component of tumor microenvironment (TME), ECM diversity constitutes the inherent heterogeneity of TME that contributes to tumor growth, dormancy, drug resistance, and metastasis. Discoidin domain receptor 1 is one of the ECM receptors that interact wit...

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Bibliographic Details
Published in:Zhongliu Fangzhi Yanjiu
Main Authors: XIONG Yixiao, YANG Shengli, ZHANG Wanguang
Format: Article
Language:Chinese
Published: Magazine House of Cancer Research on Prevention and Treatment 2023-08-01
Subjects:
tumor microenvironment
extracellular matrix
discoidin domain receptor 1
Online Access:http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2023.23.0247
Description
Summary:Tumor extracellular matrix (ECM) is the center component of tumor microenvironment (TME), ECM diversity constitutes the inherent heterogeneity of TME that contributes to tumor growth, dormancy, drug resistance, and metastasis. Discoidin domain receptor 1 is one of the ECM receptors that interact with multiple ECM ligands. It also regulates the occurrence and development of tumors. Accordingly, DDR1 plays an increasingly important role in the prevention, diagnosis, and treatment of cancer. In this review, we primarily summarize the research of ECM and its receptors with components, regulation, cell receptors, and signaling pathways in tumor progression.
ISSN:1000-8578

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