A comparative study between the efficacy of simple collagen dressing and antimicrobial-based collagen dressing in the treatment of diabetic and non-diabetic ulcers
Background: Chronic ulcers, especially diabetic foot ulcers, pose significant clinical challenges due to prolonged healing time, high infection rates, and increased health-care costs. Aims and Objectives: This study evaluates and compares the efficacy of simple collagen sheet dressing and antimic...
| 出版年: | Asian Journal of Medical Sciences |
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| 主要な著者: | , , , |
| フォーマット: | 論文 |
| 言語: | 英語 |
| 出版事項: |
Manipal College of Medical Sciences, Pokhara
2025-09-01
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| 主題: | |
| オンライン･アクセス: | https://ajmsjournal.info/index.php/AJMS/article/view/4687 |
| _version_ | 1849326454216589312 |
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| author | Vinith Prakasam Rajeev Sinha Sudhir Kumar Rajkumar Verma |
| author_facet | Vinith Prakasam Rajeev Sinha Sudhir Kumar Rajkumar Verma |
| author_sort | Vinith Prakasam |
| collection | DOAJ |
| container_title | Asian Journal of Medical Sciences |
| description | Background: Chronic ulcers, especially diabetic foot ulcers, pose significant clinical challenges due to prolonged healing time, high infection rates, and increased health-care costs.
Aims and Objectives: This study evaluates and compares the efficacy of simple collagen sheet dressing and antimicrobial-based collagen ointment dressing in treating diabetic and nondiabetic ulcers.
Materials and Methods: The study employs a prospective, comparative research design. A total of 100 patients with chronic ulcers were included in this study. They were randomly (simple randomization by random number generator software, Statistical Package for the Social Sciences version 22) assigned to two groups: one group received antimicrobial-based collagen ointment dressings (n=50), and the other received simple collagen sheet dressings (n=50). The primary outcomes measured included wound size reduction, granulation tissue formation, infection rates (pus discharge), and epithelialization. Follow-up assessments were made at 7, 14, 21, 28, 35, and 42 days.
Results: The simple collagen sheet group showed faster wound healing, greater granulation tissue formation, reduced infection, and significantly lower Bates–Jensen wound assessment tool scores over time (P<0.0001). Differences were notable in both diabetic and non-diabetic cohorts.
Conclusion: Simple collagen sheet dressings provide superior outcomes versus antimicrobial-based collagen ointment dressings, especially in non-diabetic ulcers. Wider adoption in clinical practice is recommended. |
| format | Article |
| id | doaj-art-e4a30d45fd544945b192cd9e46be7dcb |
| institution | Directory of Open Access Journals |
| issn | 2467-9100 2091-0576 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| spelling | doaj-art-e4a30d45fd544945b192cd9e46be7dcb2025-09-01T12:31:10ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762025-09-01169155161https://doi.org/10.71152/ajms.v16i9.4687A comparative study between the efficacy of simple collagen dressing and antimicrobial-based collagen dressing in the treatment of diabetic and non-diabetic ulcersVinith Prakasam 0https://orcid.org/0009-0004-1708-9125Rajeev Sinha 1https://orcid.org/0000-0002-6653-6989Sudhir Kumar2https://orcid.org/0000-0002-2918-6668Rajkumar Verma 3https://orcid.org/0009-0002-4645-4529Postgraduate Resident, Department of General Surgery, Maharani Laxmi Bai Medical College, Jhansi, Uttar Pradesh, India Professor, Department of General Surgery, Maharani Laxmi Bai Medical College, Jhansi, Uttar Pradesh, India Professor and Head, Department of Plastic Surgery, Maharani Laxmi Bai Medical College, Jhansi, Uttar Pradesh, India Professor, Department of General Surgery, Maharani Laxmi Bai Medical College, Jhansi, Uttar Pradesh, India Background: Chronic ulcers, especially diabetic foot ulcers, pose significant clinical challenges due to prolonged healing time, high infection rates, and increased health-care costs. Aims and Objectives: This study evaluates and compares the efficacy of simple collagen sheet dressing and antimicrobial-based collagen ointment dressing in treating diabetic and nondiabetic ulcers. Materials and Methods: The study employs a prospective, comparative research design. A total of 100 patients with chronic ulcers were included in this study. They were randomly (simple randomization by random number generator software, Statistical Package for the Social Sciences version 22) assigned to two groups: one group received antimicrobial-based collagen ointment dressings (n=50), and the other received simple collagen sheet dressings (n=50). The primary outcomes measured included wound size reduction, granulation tissue formation, infection rates (pus discharge), and epithelialization. Follow-up assessments were made at 7, 14, 21, 28, 35, and 42 days. Results: The simple collagen sheet group showed faster wound healing, greater granulation tissue formation, reduced infection, and significantly lower Bates–Jensen wound assessment tool scores over time (P<0.0001). Differences were notable in both diabetic and non-diabetic cohorts. Conclusion: Simple collagen sheet dressings provide superior outcomes versus antimicrobial-based collagen ointment dressings, especially in non-diabetic ulcers. Wider adoption in clinical practice is recommended.https://ajmsjournal.info/index.php/AJMS/article/view/4687collagen dressing; chronic ulcers; diabetic ulcers; wound healing; infection control; bates–jensen; antimicrobial collagen ointment; collagen sheet dressing |
| spellingShingle | Vinith Prakasam Rajeev Sinha Sudhir Kumar Rajkumar Verma A comparative study between the efficacy of simple collagen dressing and antimicrobial-based collagen dressing in the treatment of diabetic and non-diabetic ulcers collagen dressing; chronic ulcers; diabetic ulcers; wound healing; infection control; bates–jensen; antimicrobial collagen ointment; collagen sheet dressing |
| title | A comparative study between the efficacy of simple collagen dressing and antimicrobial-based collagen dressing in the treatment of diabetic and non-diabetic ulcers |
| title_full | A comparative study between the efficacy of simple collagen dressing and antimicrobial-based collagen dressing in the treatment of diabetic and non-diabetic ulcers |
| title_fullStr | A comparative study between the efficacy of simple collagen dressing and antimicrobial-based collagen dressing in the treatment of diabetic and non-diabetic ulcers |
| title_full_unstemmed | A comparative study between the efficacy of simple collagen dressing and antimicrobial-based collagen dressing in the treatment of diabetic and non-diabetic ulcers |
| title_short | A comparative study between the efficacy of simple collagen dressing and antimicrobial-based collagen dressing in the treatment of diabetic and non-diabetic ulcers |
| title_sort | comparative study between the efficacy of simple collagen dressing and antimicrobial based collagen dressing in the treatment of diabetic and non diabetic ulcers |
| topic | collagen dressing; chronic ulcers; diabetic ulcers; wound healing; infection control; bates–jensen; antimicrobial collagen ointment; collagen sheet dressing |
| url | https://ajmsjournal.info/index.php/AJMS/article/view/4687 |
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