Engineering the Vasculature of Stem-Cell-Derived Liver Organoids
The vasculature of stem-cell-derived liver organoids can be engineered using methods that recapitulate embryonic liver development. Hepatic organoids with a vascular network offer great application prospects for drug screening, disease modeling, and therapeutics. However, the application of stem cel...
| Published in: | Biomolecules |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
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| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/11/7/966 |
| _version_ | 1851841232877125632 |
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| author | Xv Zhang Liling Tang Qian Yi |
| author_facet | Xv Zhang Liling Tang Qian Yi |
| author_sort | Xv Zhang |
| collection | DOAJ |
| container_title | Biomolecules |
| description | The vasculature of stem-cell-derived liver organoids can be engineered using methods that recapitulate embryonic liver development. Hepatic organoids with a vascular network offer great application prospects for drug screening, disease modeling, and therapeutics. However, the application of stem cell-derived organoids is hindered by insufficient vascularization and maturation. Here, we review different theories about the origin of hepatic cells and the morphogenesis of hepatic vessels to provide potential approaches for organoid generation. We also review the main protocols for generating vascularized liver organoids from stem cells and consider their potential and limitations in the generation of vascularized liver organoids. |
| format | Article |
| id | doaj-art-e4a3667bd3fc4fcbb9204a3fe6a20c91 |
| institution | Directory of Open Access Journals |
| issn | 2218-273X |
| language | English |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-e4a3667bd3fc4fcbb9204a3fe6a20c912025-08-19T22:28:24ZengMDPI AGBiomolecules2218-273X2021-06-0111796610.3390/biom11070966Engineering the Vasculature of Stem-Cell-Derived Liver OrganoidsXv Zhang0Liling Tang1Qian Yi2Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, ChinaKey Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, ChinaDepartment of Physiology, School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, ChinaThe vasculature of stem-cell-derived liver organoids can be engineered using methods that recapitulate embryonic liver development. Hepatic organoids with a vascular network offer great application prospects for drug screening, disease modeling, and therapeutics. However, the application of stem cell-derived organoids is hindered by insufficient vascularization and maturation. Here, we review different theories about the origin of hepatic cells and the morphogenesis of hepatic vessels to provide potential approaches for organoid generation. We also review the main protocols for generating vascularized liver organoids from stem cells and consider their potential and limitations in the generation of vascularized liver organoids.https://www.mdpi.com/2218-273X/11/7/966liver organoidsstem cellsvascularizationmaturationendothelial cells |
| spellingShingle | Xv Zhang Liling Tang Qian Yi Engineering the Vasculature of Stem-Cell-Derived Liver Organoids liver organoids stem cells vascularization maturation endothelial cells |
| title | Engineering the Vasculature of Stem-Cell-Derived Liver Organoids |
| title_full | Engineering the Vasculature of Stem-Cell-Derived Liver Organoids |
| title_fullStr | Engineering the Vasculature of Stem-Cell-Derived Liver Organoids |
| title_full_unstemmed | Engineering the Vasculature of Stem-Cell-Derived Liver Organoids |
| title_short | Engineering the Vasculature of Stem-Cell-Derived Liver Organoids |
| title_sort | engineering the vasculature of stem cell derived liver organoids |
| topic | liver organoids stem cells vascularization maturation endothelial cells |
| url | https://www.mdpi.com/2218-273X/11/7/966 |
| work_keys_str_mv | AT xvzhang engineeringthevasculatureofstemcellderivedliverorganoids AT lilingtang engineeringthevasculatureofstemcellderivedliverorganoids AT qianyi engineeringthevasculatureofstemcellderivedliverorganoids |