Polygonatum cyrtonema Hua polysaccharides alleviate muscle atrophy and fat lipolysis by regulating the gut microenvironment in chemotherapy-induced cachexia

Introduction:Polygonatum cyrtonema Hua (PC) is an essential herbal medicine in China, known for improving muscle quality and enhancing physical function; its active ingredients are polysaccharides (PCPs). A previous study revealed the anti-atrophy effects of PCPs in cachectic mice. However, whether...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Rongrong Zhou, Tingting Liu, You Qin, Jing Xie, Shuihan Zhang, Yi Xie, Jia Lao, Wei He, Hongliang Zeng, Xueyang Tang, Xuefei Tian, Yuhui Qin
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-03-01
Subjects:	Polygonatum cyrtonema Hua polysaccharides chemotherapy-induced cachexia muscle atrophy gut microbiota fecal metabolites short-chain fatty acids
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1503785/full