The risks of adverse events with venlafaxine for adults with major depressive disorder: a systematic review of randomised clinical trials with meta-analysis and Trial Sequential Analysis

Abstract Aims Venlafaxine is used to treat depression worldwide. Previous reviews have demonstrated that venlafaxine lowers scores on depression rating scales, producing statistically significant results but the relevance to patients remains uncertain. Knowledge of the incidence of the adverse effec...

Full description

Bibliographic Details
Published in:	Epidemiology and Psychiatric Sciences
Main Authors:	C. B. Kamp, J. J. Petersen, P. Faltermeier, S. Juul, F. Siddiqui, J. Moncrieff, M. A. Horowitz, M. P. Hengartner, I. Kirsch, C. Gluud, J. C. Jakobsen
Format:	Article
Language:	English
Published:	Cambridge University Press 2024-01-01
Subjects:	adverse effects antidepressants depression systematic reviews
Online Access:	https://www.cambridge.org/core/product/identifier/S2045796024000520/type/journal_article

Similar Items

The risks of adverse events with venlafaxine and mirtazapine versus ‘active placebo’, placebo, or no intervention for adults with major depressive disorder: a protocol for two separate systematic reviews with meta-analysis and Trial Sequential Analysis
by: Caroline Kamp Jørgensen, et al.
Published: (2023-03-01)

The risks of adverse events with mirtazapine for adults with major depressive disorder: a systematic review with meta-analysis and trial sequential analysis
by: Caroline Barkholt Kamp, et al.
Published: (2025-01-01)

Beneficial and harmful effects of tricyclic antidepressants for adults with major depressive disorder: a systematic review with meta-analysis and trial sequential analysis
by: Janus Christian Jakobsen, et al.
Published: (2024-05-01)

Melatonin for sleep disorders in children with neurodevelopmental disorders: protocol for a systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials
by: Janus Christian Jakobsen, et al.
Published: (2022-11-01)

Deep brain stimulation for Parkinson’s disease: systematic review with meta-analysis and trial sequential analysis
by: Christian Gluud, et al.
Published: (2024-11-01)

Beneficial and harmful effects of duloxetine versus placebo, ‘active placebo’ or no intervention for adults with major depressive disorder: a systematic review with meta-analysis and trial sequential analysis of randomised clinical trials
by: Christian Gluud, et al.
Published: (2025-02-01)

Deep brain stimulation for neurological disorders: a protocol for a systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials
by: Johanne Juul Petersen, et al.
Published: (2022-10-01)

Comparison of Effect of Lavandula officinalis and Venlafaxine in Treating Depression: A Double Blind Clinical Trial
by: Masoud Nikfarjam, et al.
Published: (2017-07-01)

Adverse effects with tirzepatide: a protocol for a systematic review with meta-analysis and Trial Sequential Analysis
by: Christian Gluud, et al.
Published: (2025-04-01)

Proconvulsant effects of high doses of venlafaxine in pentylenetetrazole-convulsive rats
by: J.G. Santos Junior, et al.
Published: (2002-04-01)

Genotoxic and cytotoxic evaluation of venlafaxine in an acute and a subchronic assay in mouse
by: E. Madrigal-Bujaidar, et al.
Published: (2021-12-01)

Comparative efficacy of placebos in short-term antidepressant trials for major depression: a secondary meta-analysis of placebo-controlled trials
by: Lisa Holper, et al.
Published: (2020-09-01)

The nature and impact of antidepressant withdrawal symptoms and proposal of the Discriminatory Antidepressant Withdrawal Symptoms Scale (DAWSS)
by: Joanna Moncrieff, et al.
Published: (2024-04-01)

Antipsychotics for Parkinson’s disease: a protocol for a systematic review with network meta-analysis and trial sequential analysis
by: Janus C Jakobsen, et al.
Published: (2025-09-01)

Painful ejaculation induced by venlafaxine: a case report
by: F. Kulacaoglu
Published: (2022-06-01)

Long-term outcomes of trials in the National Institute for Health and Care Excellence depression guideline
by: Susan McPherson, et al.
Published: (2019-09-01)

Regular human insulins versus rapid-acting insulin analogues in children and adolescents with type 1 diabetes: a protocol for a systematic review with meta-analysis and Trial Sequential Analysis
by: Johanne Juul Petersen, et al.
Published: (2025-01-01)

Ivabradine for coronary artery disease and/or heart failure—a protocol for a systematic review of randomised clinical trials with meta-analysis and Trial Sequential Analysis
by: M. Maagaard, et al.
Published: (2019-02-01)

Optimization of Nasal Liposome Formulation of Venlafaxine Hydrochloride using a Box-Behnken Experimental Design
by: Sulekha Khute, MPharm, et al.
Published: (2023-01-01)

Tramadol for chronic pain in adults: protocol for a systematic review with meta-analysis and trial sequential analysis of randomised clinical trials
by: J. Barakji, et al.
Published: (2023-08-01)

Protocol for the development of a transdiagnostic core outcome set for mental health disorders in adults: the Patient Important Outcomes in Psychiatry (PIO-Psych) Initiative
by: Christian Gluud, et al.
Published: (2025-06-01)

Drug interventions for prevention of COVID-19 progression to severe disease in outpatients: a systematic review with meta-analyses and trial sequential analyses (The LIVING Project)
by: Christian Gluud, et al.
Published: (2023-06-01)

Sex-Specific and Long-Term Impacts of Early-Life Venlafaxine Exposure in Zebrafish
by: William Andrew Thompson, et al.
Published: (2022-02-01)

Low-dose venlafaxine-induced erythema multiforme: a case report
by: Maryam Rezapour, et al.
Published: (2025-04-01)

Duloxetine versus ‘active’ placebo, placebo or no intervention for major depressive disorder; a protocol for a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis
by: Faiza Siddiqui, et al.
Published: (2021-06-01)

Chronic treatment with escitalopram and venlafaxine affects the neuropeptide S pathway differently in adult Wistar rats exposed to maternal separation
by: Miłosz Gołyszny, et al.
Published: (2022-09-01)

Digoxin for atrial fibrillation and atrial flutter: A systematic review with meta-analysis and trial sequential analysis of randomised clinical trials.
by: Naqash J Sethi, et al.
Published: (2018-01-01)

Effective Degradation of Venlafaxine via Biochar Activated Persulfate: Kinetics, Transformation Products, and Toxicity Assessment
by: Alexandra A. Ioannidi, et al.
Published: (2025-09-01)

β2-adrenoceptors are essential for desipramine, venlafaxine or reboxetine action in neuropathic pain
by: Ipek Yalcin, et al.
Published: (2009-03-01)

Categorical improvements in disease severity in patients with major depressive disorder treated with vilazodone: post hoc analysis of four randomized, placebo-controlled trials
by: Durgam S, et al.
Published: (2016-12-01)

Periodontal treatment for preventing adverse pregnancy outcomes: a meta- and trial sequential analysis.
by: Falk Schwendicke, et al.
Published: (2015-01-01)

Rapid, Precise and Affordable Estimation of Venlafaxine and Its Metabolites in Highly Polluted Effluent Waters: Proof-of-Concept for Methodology
by: Snawar Hussain, et al.
Published: (2020-10-01)

Vaccines to prevent COVID-19: A living systematic review with Trial Sequential Analysis and network meta-analysis of randomized clinical trials.
by: Steven Kwasi Korang, et al.
Published: (2022-01-01)

Missing outcome data in randomised clinical trials of psychological interventions: a review of published trial reports in major psychiatry journals
by: Sophie Juul, et al.
Published: (2024-11-01)

Swiss GPs’ preferences for antidepressant treatment in mild depression: vignette-based quantitative analysis
by: Michael P. Hengartner, et al.
Published: (2021-12-01)

Aluminium adjuvants versus placebo or no intervention in vaccine randomised clinical trials: a systematic review with meta-analysis and Trial Sequential Analysis
by: Christian Gluud, et al.
Published: (2022-06-01)

RELEASE (REdressing Long-tErm Antidepressant uSE): protocol for a 3-arm pragmatic cluster randomised controlled trial effectiveness-implementation hybrid type-1 in general practice
by: Katharine A. Wallis, et al.
Published: (2023-09-01)

Adverse effects with semaglutide: a protocol for a systematic review with meta-analysis and trial sequential analysis
by: Janus Jakobsen
Published: (2024-07-01)

Antidepressants and cardiovascular adverse events: A narrative review
by: Mohammad Hassan Nezafati, et al.
Published: (2015-09-01)

Adverse cardiac events in ICU patients with presumptive antidepressant overdose
by: PR Hunziker, et al.
Published: (2003-09-01)