Differential subcellular distribution renders HAI-2 a less effective protease inhibitor than HAI-1 in the control of extracellular matriptase proteolytic activity

The integral membrane, Kunitz-type serine protease inhibitors HAI-1 and HAI-2, can suppress the proteolytic activity of the type 2 transmembrane serine protease matriptase with high specificity and potency. High levels of extracellular matriptase proteolytic activity have, however, been observed in...

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Bibliographic Details

Published in:	Genes and Diseases
Main Authors:	Yi-Lin Chiu, Yi-Ying Wu, Robert B. Barndt, Yu-Wen Lin, Hou-Ping Sytwo, Amy Cheng, Kacy Yang, Khee-Siang Chan, Jehng-Kang Wang, Michael D. Johnson, Chen-Yong Lin
Format:	Article
Language:	English
Published:	KeAi Communications Co., Ltd. 2022-07-01
Subjects:	HAI-1 HAI-2 Matriptase Neoplastic B-cells Proteolytic activity
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352304220301586