Differential subcellular distribution renders HAI-2 a less effective protease inhibitor than HAI-1 in the control of extracellular matriptase proteolytic activity
The integral membrane, Kunitz-type serine protease inhibitors HAI-1 and HAI-2, can suppress the proteolytic activity of the type 2 transmembrane serine protease matriptase with high specificity and potency. High levels of extracellular matriptase proteolytic activity have, however, been observed in...
| Published in: | Genes and Diseases |
|---|---|
| Main Authors: | Yi-Lin Chiu, Yi-Ying Wu, Robert B. Barndt, Yu-Wen Lin, Hou-Ping Sytwo, Amy Cheng, Kacy Yang, Khee-Siang Chan, Jehng-Kang Wang, Michael D. Johnson, Chen-Yong Lin |
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2022-07-01
|
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304220301586 |
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