Proton Pump Inhibitor-Induced Gut Dysbiosis Increases Mortality Rates for Patients with Clostridioides difficile Infection

ABSTRACT Clostridioides difficile infection (CDI) is associated with high mortality rates among patients with chronic illnesses. We aimed to identify avoidable risk factors to reduce the mortality rate in CDI patients. A total of 306 patients with diarrhea and clinical suspicion of CDI were enrolled...

Full description

Bibliographic Details
Published in:	Microbiology Spectrum
Main Authors:	Cheng-Yu Lin, Hao-Tsai Cheng, Chia-Jung Kuo, Yun-Shien Lee, Chang-Mu Sung, Micah Keidan, Krishna Rao, John Y. Kao, Sen-Yung Hsieh
Format:	Article
Language:	English
Published:	American Society for Microbiology 2022-08-01
Subjects:	CDI-associated gut dysbiosis PPI-induced gut dysbiosis gut microbiota
Online Access:	https://journals.asm.org/doi/10.1128/spectrum.00486-22

Similar Items

Effects of proton pump inhibitor (PPI) use on migraine – a critical review
by: Viktoria Tischler-Strasser, et al.
Published: (2025-01-01)

Gut Dysbiosis and Clostridioides difficile Infection in Neonates and Adults
by: Iulia-Magdalena Vasilescu, et al.
Published: (2022-01-01)

Gut microbiome therapy: fecal microbiota transplantation vs live biotherapeutic products
by: Do-Yeon Kim, et al.
Published: (2024-12-01)

Retraction: Human gut microbiota: dysbiosis and manipulation
by: Frontiers in Microbiology
Published: (2013-12-01)

Proton pump inhibitors and gut microbiota dysbiosis: insights into the pathogenesis of ulcerative colitis
by: Feng Cao, et al.
Published: (2025-10-01)

Clostridioides difficile concentration-dependant alterations in gut microbiota of asymptomatic infants
by: Aleksander Mahnic, et al.
Published: (2025-04-01)

Diarrheal-associated gut dysbiosis in cancer and inflammatory bowel disease patients is exacerbated by Clostridioides difficile infection
by: Maria Kulecka, et al.
Published: (2023-07-01)

Risk Factors for Gut Dysbiosis in Early Life
by: Kimberley Parkin, et al.
Published: (2021-09-01)

Gut dysbiosis: A pathway to glucose dysregulation?
by: Yakubu Lawal
Published: (2022-01-01)

Short-Term Dietary Intervention with Whole Oats Protects from Antibiotic-Induced Dysbiosis
by: Stephen K. Costa, et al.
Published: (2023-08-01)

From Dysbiosis to Neurodegenerative Diseases through Different Communication Pathways: An Overview
by: Giorgia Intili, et al.
Published: (2023-01-01)

The Gut–Organ Axis within the Human Body: Gut Dysbiosis and the Role of Prebiotics
by: Georgia Saxami, et al.
Published: (2023-10-01)

Clinical Significance of Changes in Gut Microbiome Associated with Use of Proton Pump Inhibitors
by: Tae Jun Kim, et al.
Published: (2020-09-01)

Gut Microbiota Dysbiosis: Pathogenesis, Diseases, Prevention, and Therapy
by: Yao Shen, et al.
Published: (2025-05-01)

Emerging story of gut dysbiosis in spondyloarthropathy: From gastrointestinal inflammation to spondyloarthritis
by: Xing Lyu, et al.
Published: (2022-08-01)

The Influence of Gut Dysbiosis in the Pathogenesis and Management of Ischemic Stroke
by: Saravana Babu Chidambaram, et al.
Published: (2022-04-01)

Editorial: Intestinal Dysbiosis in Inflammatory Diseases
by: Gislane Lelis Vilela de Oliveira, et al.
Published: (2021-07-01)

Gut dysbiosis: Nutritional causes and risk prevention in poultry, with reference to other animals
by: A Salahi, et al.
Published: (2025-07-01)

Distinct enterotypes and dysbiosis: unraveling gut microbiota in pulmonary and critical care medicine inpatients
by: Naijian Li, et al.
Published: (2024-08-01)

Gut dysbiosis in rheumatic diseases: A systematic review and meta-analysis of 92 observational studies
by: Yilun Wang, et al.
Published: (2022-06-01)

Functional metagenomic and metabolomics analysis of gut dysbiosis induced by hyperoxia
by: Yulan Cai, et al.
Published: (2023-09-01)

Dysbiosis of gut microbiota and human diseases
by: Sangeeta Huidrom, et al.
Published: (2020-01-01)

Corrigendum: Functional metagenomic and metabolomics analysis of gut dysbiosis induced by hyperoxia
by: Yulan Cai, et al.
Published: (2024-02-01)

Chronic blue light-emitting diode exposure harvests gut dysbiosis related to cholesterol dysregulation
by: Cheng-Hsieh Huang, et al.
Published: (2024-01-01)

<i>Bacillus subtilis</i> HU58 and <i>Bacillus coagulans</i> SC208 Probiotics Reduced the Effects of Antibiotic-Induced Gut Microbiome Dysbiosis in an M-SHIME<sup>®</sup> Model
by: Massimo Marzorati, et al.
Published: (2020-07-01)

Periodontal Inflammation and Dysbiosis Relate to Microbial Changes in the Gut
by: Angela R. Kamer, et al.
Published: (2024-06-01)

Dysbiosis of gut microbiota in patients with severe COVID‐19
by: Kentaro Shimizu, et al.
Published: (2024-01-01)

The Link between Obesity, Microbiota Dysbiosis, and Neurodegenerative Pathogenesis
by: Emanuel Vamanu, et al.
Published: (2021-06-01)

Dysbiosis in the Gut Microbiome of Pembrolizumab‐Treated Non‐Small Lung Cancer Patients Compared to Healthy Controls Characterized Through Opportunistic Sampling
by: Haris Charalambous, et al.
Published: (2025-05-01)

The gut dysbiosis of mothers with gestational diabetes and its correlation with diet
by: Roya Sohrabi, et al.
Published: (2025-05-01)

Correlation between gut microbiota dysbiosis and colorectal cancer: review
by: Zuzanna Chilimoniuk, et al.
Published: (2024-09-01)

Role of enteric dysbiosis in the development of central obesity: A review
by: Oluwatobi Victoria Obayomi, et al.
Published: (2024-06-01)

Gut Dysbiosis: A New Avenue for Stroke Prevention and Therapeutics
by: Shin Young Park, et al.
Published: (2023-08-01)

Fungal Dysbiosis and Intestinal Inflammation in Children With Beta-Cell Autoimmunity
by: Jarno Honkanen, et al.
Published: (2020-03-01)

Protective Effect of Baicalin against <i>Clostridioides difficile</i> Infection in Mice
by: Abraham Joseph Pellissery, et al.
Published: (2021-07-01)

Characterization of gut dysbiosis and intestinal barrier dysfunction in patients with metabolic dysfunction-associated steatotic liver disease and chronic kidney disease: a comparative study
by: Thasinas Dissayabutra, et al.
Published: (2025-05-01)

Gut bacterial and fungal dysbiosis in tuberculosis patients
by: MeiQing Han, et al.
Published: (2024-04-01)

Intestinal microflora dysbiosis and resistome in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)
by: Katia Djenadi, et al.
Published: (2024-09-01)

Perspectives on Berberine and the Regulation of Gut Microbiota: As an Anti-Inflammatory Agent
by: Quintero Vargas Jael Teresa de Jesús, et al.
Published: (2025-01-01)

Pain and Opioid-Induced Gut Microbial Dysbiosis
by: Karen R. Thomas, et al.
Published: (2022-07-01)