Review Artikel : Perkembangan Vaksin untuk Schistosoma japonicum

• Published in: Jurnal Vektor Penyakit
• Main Author: Anis Nurwidayati
• Format: Article
• Language: English
• Published: Badan Penelitian dan Pengembangan Kesehatan 2017-02-01
• Subjects: schistosomiasis; Schistosoma japonicum; vaccine
• Online Access: http://ejournal.litbang.depkes.go.id/index.php/vektorp/article/view/6260

Schistosomiasis<span> </span>infects<span> </span>261<span> </span>million<span> </span>people<span> </span>in<span> </span>78<span> </span>countries<span> </span>with<span> </span>600<span> </span>million<span> </span>people<span> </span>at<span> </span>risk<span> </span>of<span> </span> infection.<span> </span> Schistosomiasis<span> </span> in<span> </span> Indonesia<span> </span> is<span> </span> due<span> </span> to<span> </span> blood<span> </span> trematode<span> </span> <em>Schistosoma japonicum</em><span> </span> and<span> </span> <em>Oncomelania hupensis lindoensis</em><span> </span> snail<span> </span> as<span> </span> intermediate<span> </span> host .Schistosomiasis<span> </span> control<span> </span> is<span> </span> conducted<span> </span> by<span> </span> the<span> </span> management<span> </span> of<span> </span> environment<span> </span> as<span> </span> well<span> </span> as<span> </span>treatment<span> </span> with<span> </span><em>praziquantel.</em><span> </span> The<span> </span>long<span> </span> periode<span> </span>and<span> </span>continously<span> </span> drug<span> </span>use<span> </span>may<span> </span>result<span> </span> in<span> </span>drug<span> </span> resistance.<span> </span> Based<span> </span> on<span> </span> these,<span> </span> vaccines<span> </span> against<span> </span> schistosomiasis,<span> </span> as<span> </span> schistosomiasis<span> </span>control<span> </span>strategies<span> </span>in<span> </span>the<span> </span>future,<span> </span>is<span> </span>needed.<span> </span>This<span> </span>review<span> </span>was<span> </span>aimed<span> </span>to<span> </span>describe<span> </span>some<span> </span>of<span> </span>the<span> </span>vaccine<span> </span>candidates<span> </span>against<span> </span><em>S. japonicum</em><span> </span>with<span> </span>their<span> </span>level<span> </span>of<span> </span>efficacy,<span> </span> which<span> </span>composed<span> </span>by<span> </span>many<span> </span> schistosomiasis<span> </span> vaccine-related<span> </span> scientific<span> </span> literature.<span> </span> Schistosomiasis<span> </span> vaccine<span> </span>candidate<span> </span>proteins<span> </span>showed<span> </span>varying<span> </span>levels<span> </span>of<span> </span>efficacy<span> </span>and<span> </span>no<span> </span>one<span> </span>has<span> </span>the<span> </span>most<span> </span>potential.<span> </span>Although<span> </span> the<span> </span> development<span> </span> of<span> </span> vaccines<span> </span> against<span> </span> schistosomiasis<span> </span> is<span> </span> quite<span> </span> difficult,<span> </span> the<span> </span>research<span> </span> must<span> </span>still<span> </span> be<span> </span> continued