Positive allosteric modulation of emodepside sensitive Brugia malayi SLO-1F and Onchocerca volvulus SLO-1A potassium channels by GoSlo-SR-5-69.

Human lymphatic filariasis and onchocerciasis are Neglected Tropical Diseases (NTDs), of major public health concern. Prophylaxis and treatment rely on anthelmintics that effectively eliminate migrating microfilariae but lack efficacy against adult filarial worms. To expedite the elimination of both...

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Bibliographic Details

Published in:	PLoS Pathogens
Main Authors:	Mark McHugh, Charity N Njeshi, Nathaniel Smith, Sudhanva S Kashyap, Real Datta, Han Sun, Alan P Robertson, Richard J Martin
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2025-09-01
Online Access:	https://doi.org/10.1371/journal.ppat.1012946