MicroRNAs in neural stem cells and neurogenesis

MicroRNA (miRNA) is a type of short-length (~22 nt) non-coding RNA. Most miRNAs are transcribed by RNA polymerase II and processed by Drosha-DGCR8 and Dicer complexes in the cropping and dicing steps, respectively. miRNAs are exported by exportin-5 from the nucleus to the cytoplasm after cropping. T...

Full description

Bibliographic Details
Published in:	Frontiers in Neuroscience
Main Authors:	Hironori eKawahara, Takao eImai, Hideyuki eOkano
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2012-03-01
Subjects:	Neural Stem Cells Neurogenesis Let-7 Lin28 microRNA biogenesis Musashi1
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fnins.2012.00030/full

Similar Items

Biogenesis and regulation of the let-7 miRNAs and their functional implications
by: Hosuk Lee, et al.
Published: (2015-09-01)

LIN28 upregulation in primary human T cells impaired CAR T antitumoral activity
by: Patricia Garcia-Rodriguez, et al.
Published: (2024-10-01)

PCAF-mediated acetylation of Lin28B increases let-7 biogenesis in lung adenocarcinoma H1299 cells
by: Ting-ting Qu, et al.
Published: (2018-01-01)

Lin28a/let-7 pathway modulates the Hox code via Polycomb regulation during axial patterning in vertebrates
by: Tempei Sato, et al.
Published: (2020-05-01)

Multi-Level Regulatory Interactions between NF-κB and the Pluripotency Factor Lin28
by: William T. Mills, et al.
Published: (2020-12-01)

The process of microRNAs discovery
by: Paweł Kawalec
Published: (2020-09-01)

LIN28B expression is downregulated in mature spermatozoa of oligozoospermic men and associates with genetic variants previously linked to pubertal onset
by: María Cecilia Lardone, et al.
Published: (2025-05-01)

LIN28B promotes neuroblastoma metastasis and regulates PDZ binding kinase
by: Dongdong Chen, et al.
Published: (2020-06-01)

Merlin/NF2-Lin28B-let-7 Is a Tumor-Suppressive Pathway that Is Cell-Density Dependent and Hippo Independent
by: Hiroki Hikasa, et al.
Published: (2016-03-01)

Evolution of a research field—a micro (RNA) example
by: Máire-Caitlín Casey, et al.
Published: (2015-03-01)

Proto-oncogene c-Myb potentiates cisplatin resistance of ovarian cancer cells by downregulating lncRNA NKILA and modulating cancer stemness and LIN28A-let7 axis
by: Xue-Yan Zhang, et al.
Published: (2024-05-01)

p53 Mediates GnRH Secretion via Lin28/let-7 System in GT1-7 Cells
by: Chen T, et al.
Published: (2020-12-01)

MicroRNAs in opioid addiction: elucidating evolution.
by: Emily Jane Wood, et al.
Published: (2012-11-01)

Dynamic Roles of microRNAs in Neurogenesis
by: Ming-Fei eLang, et al.
Published: (2012-05-01)

<i>Lin28b-let-7</i> Modulates mRNA Expression of <i>GnRH1</i> Through Multiple Signaling Pathways Related to Glycolysis in GT1-7 Cells
by: Yujing Xie, et al.
Published: (2025-01-01)

The LIN28B–let‐7–PBK pathway is essential for group 3 medulloblastoma tumor growth and survival
by: Shubin W. Shahab, et al.
Published: (2023-09-01)

Antiproliferative effect of urolithin A, the ellagic acid-derived colonic metabolite, on hepatocellular carcinoma HepG2.2.15 cells by targeting Lin28a/let-7a axis
by: Zhenpeng Qiu, et al.
Published: (2018-05-01)

Trophectoderm Transcriptome Analysis in LIN28 Knockdown Ovine Conceptuses Suggests Diverse Roles of the LIN28-let-7 Axis in Placental and Fetal Development
by: Asghar Ali, et al.
Published: (2022-04-01)

Repressing Ago2 mRNA translation by Trim71 maintains pluripotency through inhibiting let-7 microRNAs
by: Qiuying Liu, et al.
Published: (2021-02-01)

RETRACTED ARTICLE: N6-methyladenosine modification of circMARK2 enhances cytoplasmic export and stabilizes LIN28B, contributing to the progression of Wilms tumor
by: Guannan Shu, et al.
Published: (2024-07-01)

Approaches to manipulating microRNAs in neurogenesis
by: Haijun eZhang, et al.
Published: (2013-01-01)

Sex disparity in adult asthma—A potential immunomodulatory role of let‐7 family microRNAs
by: Carina Malmhäll, et al.
Published: (2025-03-01)

<i>let-7</i> microRNAs: Their Role in Cerebral and Cardiovascular Diseases, Inflammation, Cancer, and Their Regulation
by: David L. Bernstein, et al.
Published: (2021-05-01)

Role of LIN28B in the Regulation of Ribosomal Biogenesis and Lipid Metabolism in Medulloblastoma Brain Cancer Cells
by: Ahmed Maklad, et al.
Published: (2025-03-01)

Increased number of neural progenitors in human temporal lobe epilepsy
by: Arielle Crespel, et al.
Published: (2005-08-01)

The role of Wnt/β-catenin-lin28a/let-7 axis in embryo implantation competency and epithelial-mesenchymal transition (EMT)
by: Qian Li, et al.
Published: (2020-07-01)

Let-7 Family microRNAs Regulate the Expression of the Urokinase-Receptor in Acute Myeloid Leukemia Cells
by: Anna Li Santi, et al.
Published: (2025-04-01)

Study on the Function and Mechanism of Lin28B in the Formation of Chicken Primordial Germ Cells
by: Qisheng Zuo, et al.
Published: (2020-12-01)

Cerebral dopamine neurotrophic factor promotes the proliferation and differentiation of neural stem cells in hypoxic environments
by: Chao-Qun Lin, et al.
Published: (2020-01-01)

Expression of Let-7d MicroRNA in Colorectal Cancer Patients
by: Mohammad Arefi, et al.
Published: (2023-10-01)

MicroRNAs Engage in Complex Circuits Regulating Adult Neurogenesis
by: Laura Stappert, et al.
Published: (2018-11-01)

Regulation of HSC development and function by Lin28b
by: Grant Cox, et al.
Published: (2025-03-01)

Let-7 microRNAs Are Possibly Associated with Perineural Invasion in Colorectal Cancer by Targeting IGF Axis
by: Andrei Marian Niculae, et al.
Published: (2022-10-01)

Lin28 regulates thymic growth and involution and correlates with MHCII expression in thymic epithelial cells
by: Shiyun Xiao, et al.
Published: (2023-10-01)

Quercetin Improves Hippocampal Neurogenesis in Depression by Regulating the Level of Let-7e-5p in Microglia Exosomes
by: Xie Y, et al.
Published: (2025-03-01)

Does Lin28 antagonize miRNA-mediated repression by displacing miRISC from target mRNAs?
by: Amanda N Kallen, et al.
Published: (2012-11-01)

The oncogenic microRNA miR-222 promotes human LINE-1 retrotransposition
by: Tomer Friehmann, et al.
Published: (2025-12-01)

Modulation of Alpha-synuclein Expression and Associated Effects by MicroRNA Let-7 in Transgenic C. elegans
by: Shamsuzzama, et al.
Published: (2017-10-01)

Exosomes derived from cancer-associated fibroblasts promote tumorigenesis, metastasis and chemoresistance of colorectal cancer by upregulating circ_0067557 to target Lin28
by: Cheng Yang, et al.
Published: (2024-01-01)

Effect of a Novel Variant with Let-7c MicroRNA Gene on Litter Size in Markhoz Goats
by: Emel Zergani, et al.
Published: (2022-12-01)