Longitudinal changes in cardiac mIBG scintigraphy in mild cognitive impairment with Lewy bodies

• 發表在: BJPsych Open
• Main Authors: Gemma Greenfinch, Calum A. Hamilton, Paul C. Donaghy, Michael Firbank, Nicola A. Barnett, Louise Allan, George S. Petrides, John-Paul Taylor, John T. O'Brien, Alan J. Thomas
• 格式: Article
• 語言: 英语
• 出版: Cambridge University Press 2024-11-01
• 主題: Cardiac mIBG; sympathetic innervation; DLB; MCI-LB; Lewy body disease
• 在線閱讀: https://www.cambridge.org/core/product/identifier/S205647242400766X/type/journal_article
• ISSN: 2056-4724

The aim of this study was to determine whether there was a significant change in cardiac [123I]-metaiodobenzylguanidine uptake between baseline and follow-up in individuals with mild cognitive impairment with Lewy bodies (MCI-LB) who had normal baseline scans. Eight participants with a diagnosis of probable MCI-LB and a normal baseline scan consented to a follow-up scan between 2 and 4 years after baseline. All eight repeat scans remained normal; however, in three cases uptake decreased by more than 10%. The mean change in uptake between baseline and repeat was −5.2% (range: −23.8% to +7.0%). The interpolated mean annual change in uptake was −1.6%.