Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way Street
Cancer predisposition syndromes are entities determined especially by germinal pathogenic variants, with most of them autosomal dominantly inherited. The risk of a form of cancer is variable throughout life and affects various organs, including the thyroid. Knowing the heterogeneous clinical picture...
| Published in: | Biomedicines |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-07-01
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| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/11/8/2143 |
| _version_ | 1851890269532717056 |
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| author | Ioana Balinisteanu Monica-Cristina Panzaru Lavinia Caba Maria-Christina Ungureanu Andreea Florea Ana Maria Grigore Eusebiu Vlad Gorduza |
| author_facet | Ioana Balinisteanu Monica-Cristina Panzaru Lavinia Caba Maria-Christina Ungureanu Andreea Florea Ana Maria Grigore Eusebiu Vlad Gorduza |
| author_sort | Ioana Balinisteanu |
| collection | DOAJ |
| container_title | Biomedicines |
| description | Cancer predisposition syndromes are entities determined especially by germinal pathogenic variants, with most of them autosomal dominantly inherited. The risk of a form of cancer is variable throughout life and affects various organs, including the thyroid. Knowing the heterogeneous clinical picture and the existing genotype–phenotype correlations in some forms of thyroid cancer associated with these syndromes is important for adequate and early management of patients and families. This review synthesizes the current knowledge on genes and proteins involved in cancer predisposition syndromes with thyroid cancer and the phenomena of heterogeneity (locus, allelic, mutational, and clinical). |
| format | Article |
| id | doaj-art-e51aa494f3ff4db68dabbebdc9aa386a |
| institution | Directory of Open Access Journals |
| issn | 2227-9059 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-e51aa494f3ff4db68dabbebdc9aa386a2025-08-19T22:09:53ZengMDPI AGBiomedicines2227-90592023-07-01118214310.3390/biomedicines11082143Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way StreetIoana Balinisteanu0Monica-Cristina Panzaru1Lavinia Caba2Maria-Christina Ungureanu3Andreea Florea4Ana Maria Grigore5Eusebiu Vlad Gorduza6Endocrinology Department, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Medical Genetics, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Medical Genetics, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaEndocrinology Department, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Medical Genetics, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Medical Genetics, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Medical Genetics, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaCancer predisposition syndromes are entities determined especially by germinal pathogenic variants, with most of them autosomal dominantly inherited. The risk of a form of cancer is variable throughout life and affects various organs, including the thyroid. Knowing the heterogeneous clinical picture and the existing genotype–phenotype correlations in some forms of thyroid cancer associated with these syndromes is important for adequate and early management of patients and families. This review synthesizes the current knowledge on genes and proteins involved in cancer predisposition syndromes with thyroid cancer and the phenomena of heterogeneity (locus, allelic, mutational, and clinical).https://www.mdpi.com/2227-9059/11/8/2143cancer predisposition syndromesthyroid cancerheterogeneity |
| spellingShingle | Ioana Balinisteanu Monica-Cristina Panzaru Lavinia Caba Maria-Christina Ungureanu Andreea Florea Ana Maria Grigore Eusebiu Vlad Gorduza Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way Street cancer predisposition syndromes thyroid cancer heterogeneity |
| title | Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way Street |
| title_full | Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way Street |
| title_fullStr | Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way Street |
| title_full_unstemmed | Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way Street |
| title_short | Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way Street |
| title_sort | cancer predisposition syndromes and thyroid cancer keys for a short two way street |
| topic | cancer predisposition syndromes thyroid cancer heterogeneity |
| url | https://www.mdpi.com/2227-9059/11/8/2143 |
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