Branching morphogenesis in the developing kidney is not impacted by nephron formation or integration
Branching morphogenesis of the ureteric bud is integral to kidney development; establishing the collecting ducts of the adult organ and driving organ expansion via peripheral interactions with nephron progenitor cells. A recent study suggested that termination of tip branching within the developing...
| Published in: | eLife |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2018-07-01
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| Online Access: | https://elifesciences.org/articles/38992 |
| _version_ | 1852679483734097920 |
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| author | Kieran M Short Alexander N Combes Valerie Lisnyak James G Lefevre Lynelle K Jones Melissa H Little Nicholas A Hamilton Ian M Smyth |
| author_facet | Kieran M Short Alexander N Combes Valerie Lisnyak James G Lefevre Lynelle K Jones Melissa H Little Nicholas A Hamilton Ian M Smyth |
| author_sort | Kieran M Short |
| collection | DOAJ |
| container_title | eLife |
| description | Branching morphogenesis of the ureteric bud is integral to kidney development; establishing the collecting ducts of the adult organ and driving organ expansion via peripheral interactions with nephron progenitor cells. A recent study suggested that termination of tip branching within the developing kidney involved stochastic exhaustion in response to nephron formation, with such a termination event representing a unifying developmental process evident in many organs. To examine this possibility, we have profiled the impact of nephron formation and maturation on elaboration of the ureteric bud during mouse kidney development. We find a distinct absence of random branch termination events within the kidney or evidence that nephrogenesis impacts the branching program or cell proliferation in either tip or progenitor cell niches. Instead, organogenesis proceeds in a manner indifferent to the development of these structures. Hence, stochastic cessation of branching is not a unifying developmental feature in all branching organs. |
| format | Article |
| id | doaj-art-e5499d4ad0ec4ecdbe4e140fc7cea1df |
| institution | Directory of Open Access Journals |
| issn | 2050-084X |
| language | English |
| publishDate | 2018-07-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| spelling | doaj-art-e5499d4ad0ec4ecdbe4e140fc7cea1df2025-08-19T21:29:10ZengeLife Sciences Publications LtdeLife2050-084X2018-07-01710.7554/eLife.38992Branching morphogenesis in the developing kidney is not impacted by nephron formation or integrationKieran M Short0Alexander N Combes1Valerie Lisnyak2James G Lefevre3Lynelle K Jones4Melissa H Little5Nicholas A Hamilton6Ian M Smyth7https://orcid.org/0000-0002-1727-7829Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, AustraliaMurdoch Children's Research Institute, Parkville, Australia; Department of Anatomy and Neuroscience, School of Biomedical Sciences, University of Melbourne, Parkville, AustraliaDepartment of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, AustraliaDivision of Genomics of Development and Disease, Institute for Molecular Bioscience, The University of Queensland, Brisbane, AustraliaDepartment of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, AustraliaMurdoch Children's Research Institute, Parkville, Australia; Department of Anatomy and Neuroscience, School of Biomedical Sciences, University of Melbourne, Parkville, Australia; Department of Pediatrics, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, AustraliaDivision of Genomics of Development and Disease, Institute for Molecular Bioscience, The University of Queensland, Brisbane, AustraliaDepartment of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia; Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, AustraliaBranching morphogenesis of the ureteric bud is integral to kidney development; establishing the collecting ducts of the adult organ and driving organ expansion via peripheral interactions with nephron progenitor cells. A recent study suggested that termination of tip branching within the developing kidney involved stochastic exhaustion in response to nephron formation, with such a termination event representing a unifying developmental process evident in many organs. To examine this possibility, we have profiled the impact of nephron formation and maturation on elaboration of the ureteric bud during mouse kidney development. We find a distinct absence of random branch termination events within the kidney or evidence that nephrogenesis impacts the branching program or cell proliferation in either tip or progenitor cell niches. Instead, organogenesis proceeds in a manner indifferent to the development of these structures. Hence, stochastic cessation of branching is not a unifying developmental feature in all branching organs.https://elifesciences.org/articles/38992kidney developmentbranching morphogenesisnephron formation |
| spellingShingle | Kieran M Short Alexander N Combes Valerie Lisnyak James G Lefevre Lynelle K Jones Melissa H Little Nicholas A Hamilton Ian M Smyth Branching morphogenesis in the developing kidney is not impacted by nephron formation or integration kidney development branching morphogenesis nephron formation |
| title | Branching morphogenesis in the developing kidney is not impacted by nephron formation or integration |
| title_full | Branching morphogenesis in the developing kidney is not impacted by nephron formation or integration |
| title_fullStr | Branching morphogenesis in the developing kidney is not impacted by nephron formation or integration |
| title_full_unstemmed | Branching morphogenesis in the developing kidney is not impacted by nephron formation or integration |
| title_short | Branching morphogenesis in the developing kidney is not impacted by nephron formation or integration |
| title_sort | branching morphogenesis in the developing kidney is not impacted by nephron formation or integration |
| topic | kidney development branching morphogenesis nephron formation |
| url | https://elifesciences.org/articles/38992 |
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