Silenced LASP1 interacts with DNMT1 to promote TJP2 expression and attenuate articular cartilage injury in mice by suppressing TJP2 methylation

Abstract To investigate the regulatory mechanisms and effects of LIM and SH3 protein 1 (LASP1) on osteoarthritis (OA). IL‐1β was used to induce OA in cell models. Viability and apoptosis of chondrocytes were assessed. The expressions of tumor necrsis factor‐α (TNF‐α) and IL‐6 were measured by ELISA...

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Bibliographic Details
Published in:	Kaohsiung Journal of Medical Sciences
Main Authors:	Lian Ren, Shi‐Gao Cheng, Peng‐Cheng Kang, Teng‐Fei Li, Xun Li, Jiong‐Zhe Xiao, Dong Jiang
Format:	Article
Language:	English
Published:	Wiley 2023-11-01
Subjects:	DNMT1 LASP1 methylation osteoarthritis TJP2
Online Access:	https://doi.org/10.1002/kjm2.12738

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