Therapeutic Approaches Targeting Vascular Repair After Experimental Spinal Cord Injury: A Systematic Review of the Literature

Traumatic spinal cord injury (SCI) disrupts the spinal cord vasculature resulting in ischemia, amplification of the secondary injury cascade and exacerbation of neural tissue loss. Restoring functional integrity of the microvasculature to prevent neural loss and to promote neural repair is an import...

Full description

Bibliographic Details
Published in:	Neurospine
Main Authors:	Laurens Roolfs, Vanessa Hubertus, Jacob Spinnen, Lennard K. Shopperly, Michael G. Fehlings, Peter Vajkoczy
Format:	Article
Language:	English
Published:	Korean Spinal Neurosurgery Society 2022-12-01
Subjects:	spinal cord injury blood-spinal cord barrier vascular injury spinal cord regeneration biocompatible materials therapeutics
Online Access:	http://e-neurospine.org/upload/pdf/ns-2244624-312.pdf

Similar Items

Analysis of the spatiotemporal dynamics of vascular injury and regeneration following experimental Spinal Cord Injury
by: Christian J. Entenmann, et al.
Published: (2025-01-01)

Pediatric Spinal Cord Injury: A Review
by: Natalia S. C. Cunha, et al.
Published: (2023-08-01)

Functional trajectories during innate spinal cord repair
by: Nicholas O. Jensen, et al.
Published: (2023-07-01)

From single to combinatorial therapies in spinal cord injuries for structural and functional restoration
by: Ernesto Doncel-Pérez, et al.
Published: (2025-03-01)

Spinal cord stimulation for spinal cord injury patients with paralysis: To regain walking and dignity
by: Sheng-Tzung Tsai, et al.
Published: (2021-01-01)

Multidimensional exploration of hydrogels as biological scaffolds for spinal cord regeneration: mechanisms and future perspectives
by: Chenxi Han, et al.
Published: (2025-04-01)

Research Progress on Biomaterials for Spinal Cord Repair
by: Liao Z, et al.
Published: (2025-02-01)

Tocilizumab promotes repair of spinal cord injury by facilitating the restoration of tight junctions between vascular endothelial cells
by: Yang Luo, et al.
Published: (2023-01-01)

Characteristics of Pediatric Spinal Cord Injury in South Korea: A Single-Centered Study
by: Wooyeung Kim, et al.
Published: (2022-10-01)

Advance in pediatric spinal cord injury
by: Jian Zheng, et al.
Published: (2024-03-01)

Blood-spinal cord barrier in spinal cord injury: a scientific review based on own experimental trial
by: Yu.A. Chelyshev, et al.
Published: (2024-09-01)

Neural Stem Cells: Promoting Axonal Regeneration and Spinal Cord Connectivity
by: Camila Marques de Freria, et al.
Published: (2021-11-01)

A Review of Functional Restoration From Spinal Cord Stimulation in Patients With Spinal Cord Injury
by: Alice Lin, et al.
Published: (2022-09-01)

Long-Term Spinal Cord Stimulation After Chronic Complete Spinal Cord Injury Enables Volitional Movement in the Absence of Stimulation
by: Isabela Peña Pino, et al.
Published: (2020-06-01)

Research on the Effects of Levetiracetam in Spinal Cord Injury Model in Rats: An Experimental Study
by: Egemen Nursoy,, et al.
Published: (2020-03-01)

Potential benefits of spinal cord stimulation treatment on quality of life for paralyzed patients with spinal cord injury
by: Xiang-Ling Huang, et al.
Published: (2023-01-01)

Molecular Mechanisms in the Vascular and Nervous Systems following Traumatic Spinal Cord Injury
by: Shuo Li, et al.
Published: (2022-12-01)

A hospital based cross-sectional study on clinical profile of patients with spinal cord injuries
by: G Krishnamurthy, et al.
Published: (2020-01-01)

Spinal Cord Imaging Markers and Recovery of Volitional Leg Movement With Spinal Cord Epidural Stimulation in Individuals With Clinically Motor Complete Spinal Cord Injury
by: Enrico Rejc, et al.
Published: (2020-10-01)

Graphene and graphene-based materials in axonal repair of spinal cord injury
by: Shi-Xin Wang, et al.
Published: (2022-01-01)

Case report: Continuous spinal cord physiologic monitoring following traumatic spinal cord injury—A report from the Winnipeg Intraspinal Pressure Study (WISP)
by: Perry Dhaliwal, et al.
Published: (2023-04-01)

The profile of spinal injuries in the elderly population
by: Glaciéle de Oliveira Teixeira, et al.
Published: (2014-04-01)

Developing preclinical dog models for reconstructive severed spinal cord continuity via spinal cord fusion technique
by: Tingting Shen, et al.
Published: (2024-06-01)

Case report: Combined transcutaneous spinal cord stimulation and physical therapy on recovery of neurological function after spinal cord infarction
by: Felix León, et al.
Published: (2024-11-01)

Up-regulation of MicroRNAs-21 and -223 in a Sprague-Dawley Rat Model of Traumatic Spinal Cord Injury
by: Hyo-Jin Chung, et al.
Published: (2020-03-01)

Supraspinal and Afferent Signaling Facilitate Spinal Sensorimotor Network Excitability After Discomplete Spinal Cord Injury: A Case Report
by: Alena Militskova, et al.
Published: (2020-06-01)

The Value of MicroRNAs as an Indicator of the Severity and the Acute Phase of Spinal Cord Injury
by: Junyoung Park, et al.
Published: (2019-06-01)

Pharmacologic and Regenerative Cell Therapy for Spinal Cord Injury: WFNS Spine Committee Recommendations
by: Toshihiro Takami, et al.
Published: (2020-12-01)

Spinal cord dysfunction secondary to a sports/exercise event: Two case reports
by: Edwardo Ramos, et al.
Published: (2022-01-01)

Implantation with SHED sheet induced with homogenate protein of spinal cord promotes functional recovery from spinal cord injury in rats
by: Sisi Mi, et al.
Published: (2023-03-01)

Impact of Mechanism of Injury on Long-term Neurological Outcomes of Cervical Sensorimotor Complete Acute Traumatic Spinal Cord Injury
by: Alex B. Bak, et al.
Published: (2022-12-01)

Ferroptosis inhibition protects vascular endothelial cells and maintains integrity of the blood-spinal cord barrier after spinal cord injury
by: Wenxiang Li, et al.
Published: (2023-01-01)

Established and Emerging Therapies in Acute Spinal Cord Injury
by: Ron Gadot, et al.
Published: (2022-06-01)

Pretreatment with AQP4 and NKCC1 Inhibitors Concurrently Attenuated Spinal Cord Edema and Tissue Damage after Spinal Cord Injury in Rats
by: Xiaodong Yan, et al.
Published: (2018-01-01)

Improved Motor Function in Cervical Spinal Cord Injury Following Spinal Cord Stimulation
by: Michael Suarez, et al.
Published: (2025-02-01)

Dependence of the restorative effect of Macroporous poly(N-[2-Hydroxypropyl]-methacrylamide hydrogel on the severity of experimental Lacerative Spinal Cord Injury
by: Ibrahim Abdallah, et al.
Published: (2021-12-01)

The Role of Interleukin-10 in the Pathogenesis and Treatment of a Spinal Cord Injury
by: Christos Patilas, et al.
Published: (2024-01-01)

A novel mouse model of central cord syndrome
by: Elzat Elham – Yilizati Yilihamu, et al.
Published: (2023-01-01)

Cervical Spinal Cord Injury in Patients with Cervical Canal Stenosis without Radiologic Evidence of Trauma: Evaluation of 15 Consecutive Cases
by: Burak Eren, et al.
Published: (2017-06-01)

Comprehensive treatment of a patient with complicated thoracic spine injury using percutaneous electrical spinal cord stimulation (case report)
by: Aleksei G. Baindurashvili, et al.
Published: (2020-03-01)