Mitochondrially targeted p53 or DBD subdomain is superior to wild type p53 in ovarian cancer cells even with strong dominant negative mutant p53

Abstract Background While tumor suppressor p53 functions primarily as a transcription factor in the nucleus, cellular stress can cause p53 to translocate to the mitochondria and directly trigger a rapid apoptotic response. We have previously shown that fusing p53 (or its DNA binding domain, DBD, alo...

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Bibliographic Details
Published in:Journal of Ovarian Research
Main Authors: Phong Lu, Erica R. Vander Mause, Katherine E. Redd Bowman, Sarah M. Brown, Lisa Ahne, Carol S. Lim
Format: Article
Language:English
Published: BMC 2019-05-01
Subjects:
p53
BakMTS
BaxMTS
DBD
Dominant negative
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s13048-019-0516-2

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