Liquisolid technique and its applications in pharmaceutics

Most of the newly developed drug candidates are lipophilic and poorly water-soluble. Enhancing the dissolution and bioavailability of these drugs is a major challenge for the pharmaceutical industry. Liquisolid technique, which is based on the conversion of the drug in liquid state into an apparentl...

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Published in:Asian Journal of Pharmaceutical Sciences
Main Authors: Mei Lu, Haonan Xing, Jingzheng Jiang, Xiao Chen, Tianzhi Yang, Dongkai Wang, Pingtian Ding
Format: Article
Language:English
Published: Elsevier 2017-03-01
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087616301726
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author Mei Lu
Haonan Xing
Jingzheng Jiang
Xiao Chen
Tianzhi Yang
Dongkai Wang
Pingtian Ding
author_facet Mei Lu
Haonan Xing
Jingzheng Jiang
Xiao Chen
Tianzhi Yang
Dongkai Wang
Pingtian Ding
author_sort Mei Lu
collection DOAJ
container_title Asian Journal of Pharmaceutical Sciences
description Most of the newly developed drug candidates are lipophilic and poorly water-soluble. Enhancing the dissolution and bioavailability of these drugs is a major challenge for the pharmaceutical industry. Liquisolid technique, which is based on the conversion of the drug in liquid state into an apparently dry, non-adherent, free flowing and compressible powder, is a novel and advanced approach to tackle the issue. The objective of this article is to present an overview of liquisolid technique and summarize the progress of its applications in pharmaceutics. Low cost, simple processing and great potentials in industrial production are main advantages of this approach. In addition to the enhancement of dissolution rate of poorly water-soluble drugs, this technique is also a fairly new technique to effectively retard drug release. Furthermore, liquisolid technique has been investigated as a tool to minimize the effect of pH variation on drug release and as a promising alternative to conventional coating for the improvement of drug photostability in solid dosage forms. Overall, liquisolid technique is a newly developed and promising tool for enhancing drug dissolution and sustaining drug release, and its potential applications in pharmaceutics are still being broadened.
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spelling doaj-art-e5c1f2475eac462a9ead9dffbd4bbba82025-09-03T02:35:53ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762017-03-0112211512310.1016/j.ajps.2016.09.007Liquisolid technique and its applications in pharmaceuticsMei Lu0Haonan Xing1Jingzheng Jiang2Xiao Chen3Tianzhi Yang4Dongkai Wang5Pingtian Ding6School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, ChinaSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, ChinaSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, ChinaSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, ChinaDepartment of Basic Pharmaceutical Sciences, School of Pharmacy, Husson University, Bangor, ME, USASchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, ChinaSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, ChinaMost of the newly developed drug candidates are lipophilic and poorly water-soluble. Enhancing the dissolution and bioavailability of these drugs is a major challenge for the pharmaceutical industry. Liquisolid technique, which is based on the conversion of the drug in liquid state into an apparently dry, non-adherent, free flowing and compressible powder, is a novel and advanced approach to tackle the issue. The objective of this article is to present an overview of liquisolid technique and summarize the progress of its applications in pharmaceutics. Low cost, simple processing and great potentials in industrial production are main advantages of this approach. In addition to the enhancement of dissolution rate of poorly water-soluble drugs, this technique is also a fairly new technique to effectively retard drug release. Furthermore, liquisolid technique has been investigated as a tool to minimize the effect of pH variation on drug release and as a promising alternative to conventional coating for the improvement of drug photostability in solid dosage forms. Overall, liquisolid technique is a newly developed and promising tool for enhancing drug dissolution and sustaining drug release, and its potential applications in pharmaceutics are still being broadened.http://www.sciencedirect.com/science/article/pii/S1818087616301726Liquisolid techniqueDissolution enhancementPoorly water-soluble drugsSustained releasepH variationPhotostability
spellingShingle Mei Lu
Haonan Xing
Jingzheng Jiang
Xiao Chen
Tianzhi Yang
Dongkai Wang
Pingtian Ding
Liquisolid technique and its applications in pharmaceutics
Liquisolid technique
Dissolution enhancement
Poorly water-soluble drugs
Sustained release
pH variation
Photostability
title Liquisolid technique and its applications in pharmaceutics
title_full Liquisolid technique and its applications in pharmaceutics
title_fullStr Liquisolid technique and its applications in pharmaceutics
title_full_unstemmed Liquisolid technique and its applications in pharmaceutics
title_short Liquisolid technique and its applications in pharmaceutics
title_sort liquisolid technique and its applications in pharmaceutics
topic Liquisolid technique
Dissolution enhancement
Poorly water-soluble drugs
Sustained release
pH variation
Photostability
url http://www.sciencedirect.com/science/article/pii/S1818087616301726
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AT tianzhiyang liquisolidtechniqueanditsapplicationsinpharmaceutics
AT dongkaiwang liquisolidtechniqueanditsapplicationsinpharmaceutics
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