The Role Of Vitamin D And Calcium In Pre-Eclampsia And The Association With Neonatal Outcomes

• Published in: Andalas Obstetrics and Gynecology Journal
• Main Authors: Tara Fadila, Yusrawati Yusrawati, Hudila Rifa Karmia
• Format: Article
• Language: English
• Published: Fakultas Kedokteran Universitas Andalas 2023-03-01
• Subjects: 1; 25 dihydroxy vitamin d3; calcium; pre-eclampsia; neonatal
• Online Access: https://jurnalobgin.fk.unand.ac.id/index.php/JOE/article/view/304
• ISSN: 2579-8413; 2579-8324

Introduction: Pre-eclampsia is one of the main causes of maternal and neonatal death in developing countries. A low vitamin D level can increase the risk of neonatal abnormalities. Clinical studies reported various complications of low vitamin D levels, such as pre-eclampsia, gestational diabetes, low birthweight, and caesarean section. This study aimed to investigate the role of vitamin D in pregnancy with pre-eclampsia and its association with neonatal outcomes. Methods: This is an observational analytical study uses a cross-sectional approach to investigate vitamin D levels and pre-eclampsia, conducted in General Hospital Dr. M. Djamil Padang from Mei 2021 – April 2022. A total of 5 mL blood was withdrawn to analyzed vitamin D. This study has been approved by Health Research Ethics Committee Andalas University (Approved number: 339/KEPK/2021). Results: There was a significant difference in the levels of 1,25 dihydroxy vitamin D3 between normal pregnancy and pre-eclampsia patients (99,18 vs 72,53 pg/ml; p = 0,033). In the pre-eclampsia patients’ first APGAR score, there was a significant difference in the levels of 1,25 dihydroxy vitamin D3 between normal, moderate, and severe asphyxia groups (114,19 vs 66,75 vs 74,78 pg/ml; p = 0,025). Conclusion: Measuring early maternal 1,25 dihydroxy vitamin D3 can lower the pre-eclampsia risks and the impact the perinatal outcomes, particularly in determining first Apgar scores.