Revolutionizing renal research: The future of kidney-on-a-chip in biotechnology

In vitro models of kidneys have limited effectiveness owing to the complex structure and functions of the kidney when compared with other organs. Therefore many renal function evaluations are currently being carried out through animal experiments. In contrast, efforts are being made to apply biomime...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Regenerative Therapy
المؤلف الرئيسي: Yusuke Nishimura
التنسيق: مقال
اللغة:الإنجليزية
منشور في: Elsevier 2024-06-01
الموضوعات:
الوصول للمادة أونلاين:http://www.sciencedirect.com/science/article/pii/S2352320424001135
الوصف
الملخص:In vitro models of kidneys have limited effectiveness owing to the complex structure and functions of the kidney when compared with other organs. Therefore many renal function evaluations are currently being carried out through animal experiments. In contrast, efforts are being made to apply biomimetic systems, such as organ-on-a-chip, which is based on microfluidic device technology, to serve as an in vitro model for the kidney. These systems aimed to recreate a physiological cultivation environment. This review has provided an overview of organ-on-a-chip research focused on glomeruli and tubules as in vitro models for the kidney and discusses future prospects.
تدمد:2352-3204