Associations between mixed exposure to phthalates and latent tuberculosis infection among the general U.S. population from NHANES 2011–2012
Background: People are constantly exposed to phthalates, but few reliable studies have focused on the connection between phthalate exposure and latent tuberculosis infection (LTBI). Methods: Data were obtained from the National Health and Nutrition Examination Survey (NHANES) database (2011–2012). T...
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Elsevier
2024-03-01
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| 在線閱讀: | http://www.sciencedirect.com/science/article/pii/S2405844024039896 |
| _version_ | 1850403968460521472 |
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| author | Bi Ran Jiangyue Qin Yanqiu Wu Fuqiang Wen |
| author_facet | Bi Ran Jiangyue Qin Yanqiu Wu Fuqiang Wen |
| author_sort | Bi Ran |
| collection | DOAJ |
| container_title | Heliyon |
| description | Background: People are constantly exposed to phthalates, but few reliable studies have focused on the connection between phthalate exposure and latent tuberculosis infection (LTBI). Methods: Data were obtained from the National Health and Nutrition Examination Survey (NHANES) database (2011–2012). The LTBI was assessed by QuantiFERON®-TB Gold-In-Tube (QFT) or tuberculin skin testing (TST). The odds ratios (ORs) and 95% confidence intervals (CIs) per log10 unit change in the concentration of phthalate metabolites were calculated using crude and adjusted logistic regression models. The relationships between mixed phthalate concentrations and LTBI were assessed using Bayesian kernel machine regression (BKMR) models. Results: According to the results of the multivariable logistic regression, in a fully adjusted model, only monobenzyl phthalate (MBZP) was negatively associated with LTBI in Q3 (OR (95% CI): 0.485 (0.286,0.823), P = 0.007). According to the restricted cubic spline (RCS) model, there was a linear dose‒response association between all 11 phthalate metabolites and LTBI (p for nonlinearity >0.05). We found a significant positive correlation between mixed phthalate metabolites and LTBI by using fully adjusted BKMR model. Conclusions: Our analysis demonstrated that LTBI in the general U.S. population is linearly linked with exposure to single or combined phthalates. |
| format | Article |
| id | doaj-art-e5e97e8fdaff4f5fa11ee7a77a4673af |
| institution | Directory of Open Access Journals |
| issn | 2405-8440 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
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| spelling | doaj-art-e5e97e8fdaff4f5fa11ee7a77a4673af2025-08-19T22:49:03ZengElsevierHeliyon2405-84402024-03-01106e2795810.1016/j.heliyon.2024.e27958Associations between mixed exposure to phthalates and latent tuberculosis infection among the general U.S. population from NHANES 2011–2012Bi Ran0Jiangyue Qin1Yanqiu Wu2Fuqiang Wen3Department of Respiratory and Critical Care Medicine, West China Hospital and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Sichuan University. Guoxuexiang 37, Chengdu, Sichuan, 610041, ChinaDepartment of Respiratory and Critical Care Medicine, West China Hospital and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Sichuan University. Guoxuexiang 37, Chengdu, Sichuan, 610041, China; General Practice Ward/International Medical Center Ward, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Respiratory and Critical Care Medicine, West China Hospital and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Sichuan University. Guoxuexiang 37, Chengdu, Sichuan, 610041, ChinaDepartment of Respiratory and Critical Care Medicine, West China Hospital and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Sichuan University. Guoxuexiang 37, Chengdu, Sichuan, 610041, China; Corresponding author. Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Chengdu, China.Background: People are constantly exposed to phthalates, but few reliable studies have focused on the connection between phthalate exposure and latent tuberculosis infection (LTBI). Methods: Data were obtained from the National Health and Nutrition Examination Survey (NHANES) database (2011–2012). The LTBI was assessed by QuantiFERON®-TB Gold-In-Tube (QFT) or tuberculin skin testing (TST). The odds ratios (ORs) and 95% confidence intervals (CIs) per log10 unit change in the concentration of phthalate metabolites were calculated using crude and adjusted logistic regression models. The relationships between mixed phthalate concentrations and LTBI were assessed using Bayesian kernel machine regression (BKMR) models. Results: According to the results of the multivariable logistic regression, in a fully adjusted model, only monobenzyl phthalate (MBZP) was negatively associated with LTBI in Q3 (OR (95% CI): 0.485 (0.286,0.823), P = 0.007). According to the restricted cubic spline (RCS) model, there was a linear dose‒response association between all 11 phthalate metabolites and LTBI (p for nonlinearity >0.05). We found a significant positive correlation between mixed phthalate metabolites and LTBI by using fully adjusted BKMR model. Conclusions: Our analysis demonstrated that LTBI in the general U.S. population is linearly linked with exposure to single or combined phthalates.http://www.sciencedirect.com/science/article/pii/S2405844024039896Latent tuberculosis infectionPhthalate metabolitesNHANESMultivariable logistic regressionRestricted cubic spline (RCS)Bayesian kernel machine regression (BKMR) |
| spellingShingle | Bi Ran Jiangyue Qin Yanqiu Wu Fuqiang Wen Associations between mixed exposure to phthalates and latent tuberculosis infection among the general U.S. population from NHANES 2011–2012 Latent tuberculosis infection Phthalate metabolites NHANES Multivariable logistic regression Restricted cubic spline (RCS) Bayesian kernel machine regression (BKMR) |
| title | Associations between mixed exposure to phthalates and latent tuberculosis infection among the general U.S. population from NHANES 2011–2012 |
| title_full | Associations between mixed exposure to phthalates and latent tuberculosis infection among the general U.S. population from NHANES 2011–2012 |
| title_fullStr | Associations between mixed exposure to phthalates and latent tuberculosis infection among the general U.S. population from NHANES 2011–2012 |
| title_full_unstemmed | Associations between mixed exposure to phthalates and latent tuberculosis infection among the general U.S. population from NHANES 2011–2012 |
| title_short | Associations between mixed exposure to phthalates and latent tuberculosis infection among the general U.S. population from NHANES 2011–2012 |
| title_sort | associations between mixed exposure to phthalates and latent tuberculosis infection among the general u s population from nhanes 2011 2012 |
| topic | Latent tuberculosis infection Phthalate metabolites NHANES Multivariable logistic regression Restricted cubic spline (RCS) Bayesian kernel machine regression (BKMR) |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024039896 |
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