Derepression may masquerade as activation in ligand-gated ion channels

Ligand-gated ion channels are activated/opened by agonists. Tessier et al. show that agonists can inhibit the inhibition of intrinsic basal activity, and thus that activation may instead be the manifestation of a derepression mechanism.

Bibliographic Details
Published in:Nature Communications
Main Authors: Christian J. G. Tessier, Johnathon R. Emlaw, Raymond M. Sturgeon, Corrie J. B. daCosta
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Online Access:https://doi.org/10.1038/s41467-023-36770-z
Description
Summary:Ligand-gated ion channels are activated/opened by agonists. Tessier et al. show that agonists can inhibit the inhibition of intrinsic basal activity, and thus that activation may instead be the manifestation of a derepression mechanism.
ISSN:2041-1723

Similar Items