Derepression may masquerade as activation in ligand-gated ion channels
Ligand-gated ion channels are activated/opened by agonists. Tessier et al. show that agonists can inhibit the inhibition of intrinsic basal activity, and thus that activation may instead be the manifestation of a derepression mechanism.
| الحاوية / القاعدة: | Nature Communications |
|---|---|
| المؤلفون الرئيسيون: | , , , |
| التنسيق: | مقال |
| اللغة: | الإنجليزية |
| منشور في: |
Nature Portfolio
2023-04-01
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| الوصول للمادة أونلاين: | https://doi.org/10.1038/s41467-023-36770-z |
| _version_ | 1857120493100859392 |
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| author | Christian J. G. Tessier Johnathon R. Emlaw Raymond M. Sturgeon Corrie J. B. daCosta |
| author_facet | Christian J. G. Tessier Johnathon R. Emlaw Raymond M. Sturgeon Corrie J. B. daCosta |
| author_sort | Christian J. G. Tessier |
| collection | DOAJ |
| container_title | Nature Communications |
| description | Ligand-gated ion channels are activated/opened by agonists. Tessier et al. show that agonists can inhibit the inhibition of intrinsic basal activity, and thus that activation may instead be the manifestation of a derepression mechanism. |
| format | Article |
| id | doaj-art-e5fa9addcd8a49da8c921ad38b2f143f |
| institution | Directory of Open Access Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| spelling | doaj-art-e5fa9addcd8a49da8c921ad38b2f143f2025-08-19T19:09:19ZengNature PortfolioNature Communications2041-17232023-04-011411810.1038/s41467-023-36770-zDerepression may masquerade as activation in ligand-gated ion channelsChristian J. G. Tessier0Johnathon R. Emlaw1Raymond M. Sturgeon2Corrie J. B. daCosta3Department of Chemistry and Biomolecular Sciences, Centre for Chemical and Synthetic Biology, University of OttawaDepartment of Chemistry and Biomolecular Sciences, Centre for Chemical and Synthetic Biology, University of OttawaDepartment of Chemistry and Biomolecular Sciences, Centre for Chemical and Synthetic Biology, University of OttawaDepartment of Chemistry and Biomolecular Sciences, Centre for Chemical and Synthetic Biology, University of OttawaLigand-gated ion channels are activated/opened by agonists. Tessier et al. show that agonists can inhibit the inhibition of intrinsic basal activity, and thus that activation may instead be the manifestation of a derepression mechanism.https://doi.org/10.1038/s41467-023-36770-z |
| spellingShingle | Christian J. G. Tessier Johnathon R. Emlaw Raymond M. Sturgeon Corrie J. B. daCosta Derepression may masquerade as activation in ligand-gated ion channels |
| title | Derepression may masquerade as activation in ligand-gated ion channels |
| title_full | Derepression may masquerade as activation in ligand-gated ion channels |
| title_fullStr | Derepression may masquerade as activation in ligand-gated ion channels |
| title_full_unstemmed | Derepression may masquerade as activation in ligand-gated ion channels |
| title_short | Derepression may masquerade as activation in ligand-gated ion channels |
| title_sort | derepression may masquerade as activation in ligand gated ion channels |
| url | https://doi.org/10.1038/s41467-023-36770-z |
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